Chinese Hamster Cell Lines Defective in DNA Repair
Four different general categories of mutants defective in cellular response to UV, X-rays, cross-linking and alkylat-ing agents were isolated from Chinese hamster cell lines. Novel types of mutants are described. A new 7th complementation group in the class of UV-sensitive mutants was found. Amongst two complementation groups of X-ray-sensitive mutants, one group resembles Ataxia-telangiectasia cells. Three complementation groups were identified amongst mutants sensitive to cross-linking agents; one mutant (V-H4) is homologous to Fanconi’s anemia.
KeywordsChinese Hamster Ovary Cell Nucleotide Excision Repair Ataxia Telangiectasia Xeroderma Pigmentosum Complementation Group
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