Mismatch Repair Patterns in Simian Cells Correlate with the Specificity of a Mismatch Binding Protein Isolated from Simian and HeLa Cells
Part of the
NATO ASI Series
book series (NSSA, volume 182)
Mismatches are formed in DNA during recombination of homologous but nonidentical sequences, as errors of DNA replication, and during the spontaneous hydrolytic deamination of 5-methylcytosine (Modrich, 1987). The efficiency and specificity of mismatch correction thus influences the outcome of genetic events such as gene conversion (Holliday, 1974; White, et al., 1985; Kourilsky, 1986), homogenization of repeated sequence families (Dover, 1986), generation of antibody diversity (Baltimore, 1974; Kunkel, et al., 1986), and DNA replication fidelity (Hare and Taylor, 1985; Reyland and Loeb, 1987). In addition, specific repair of G/T mismatches to G/C may stabilize patterns of 5-methylcytosine distribution (Brown and Jiricny, 1987).
KeywordsRecombination Polyacrylamide Cytosine Guanine Dinucleotide
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