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Mismatch Repair Patterns in Simian Cells Correlate with the Specificity of a Mismatch Binding Protein Isolated from Simian and HeLa Cells

  • J. Jiricny
  • T. C. Brown
  • N. Corman
  • B. B. Rudkin
Part of the NATO ASI Series book series (NSSA, volume 182)

Abstract

Mismatches are formed in DNA during recombination of homologous but nonidentical sequences, as errors of DNA replication, and during the spontaneous hydrolytic deamination of 5-methylcytosine (Modrich, 1987). The efficiency and specificity of mismatch correction thus influences the outcome of genetic events such as gene conversion (Holliday, 1974; White, et al., 1985; Kourilsky, 1986), homogenization of repeated sequence families (Dover, 1986), generation of antibody diversity (Baltimore, 1974; Kunkel, et al., 1986), and DNA replication fidelity (Hare and Taylor, 1985; Reyland and Loeb, 1987). In addition, specific repair of G/T mismatches to G/C may stabilize patterns of 5-methylcytosine distribution (Brown and Jiricny, 1987).

Keywords

Mismatch Repair Short Patch Specific Repair Parental Strand Mismatch Correction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • J. Jiricny
    • 1
  • T. C. Brown
    • 1
  • N. Corman
    • 1
  • B. B. Rudkin
    • 1
  1. 1.Friedrich Miescher-InstitutBaselSwitzerland

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