Molecular Interactions of Organophosphates (OPs), Oximes and Carbamates at Nicotinic Receptors

  • Edson X. Albuquerque
  • Manickavasagom Alkondon
  • Sharad S. Deshpande
  • Vanga K. Reddy
  • Yasco Aracava

Abstract

The nicotinic acetylcholine receptor-ion channel macromolecule (AChR), which is densely distributed at the endplate region of skeletal muscle and in Torpedo electric organ, is the best characterized among agonist-gated ion channels (Karlin, 1980; Spivak and Albuquerque, 1982; Noda et al., 1983; Changeux et al., 1984; Sakmann et al., 1985). This molecule comprises the neurotransmitter recognition site and the ion channel and is formed by five polypeptide subunits α, β, γ, and δ with a stoichiometry of 2:1:1:1. The subunits of the ion channel traverse the mem­brane and protrude about 50 Å towards the extracellular side and 15 Å towards the interior side of the cell membrane (Ross et al., 1977; Klymkowsky et al., 1980).

Keywords

Acetylcholine Atropine Bupivacaine Myopathy Cholinesterase 

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Edson X. Albuquerque
    • 1
    • 2
  • Manickavasagom Alkondon
    • 1
  • Sharad S. Deshpande
    • 1
  • Vanga K. Reddy
    • 1
  • Yasco Aracava
    • 1
    • 2
  1. 1.Department of Pharmacology and Experimental TherapeuticsUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Molecular Pharmacology Training Program Institute of Biophysics “Carlos Chagas Filho”Federal University of Rio de JaneiroRio de JaneiroBrazil

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