Cytoskeletal Organisation in the Apex of Cochlear Hair Cells
The cytoskeleton is an essential component of cells, performing biomechanical functions ranging from support to motility and intracellular transport. Two major cytoskeletal proteins which occur ubiquitously in eukaryotic cells are actin and tubulin. Actin occurs with actin-binding and actin-bundling proteins, where it functions primarily to provide support or stiffening, and with myosin and tropomyosin, a combination often associated with motility, in both muscle and nonmuscle cells. Tubulin occurs mainly in the form of microtubules which perform functions ranging from cell shape determination to motility in a wide variety of mammalian cells, as well as in cells in lower vertebrates and invertebrates (for reviews on the cytoskeleton see Stebbings and Hyams, 1979; Tucker, 1979).
KeywordsHair Cell Actin Filament Outer Hair Cell Thick Filament Actin Bundle
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