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Cytoskeletal Organisation in the Apex of Cochlear Hair Cells

  • David N. Furness
  • Carole M. Hackney

Abstract

The cytoskeleton is an essential component of cells, performing biomechanical functions ranging from support to motility and intracellular transport. Two major cytoskeletal proteins which occur ubiquitously in eukaryotic cells are actin and tubulin. Actin occurs with actin-binding and actin-bundling proteins, where it functions primarily to provide support or stiffening, and with myosin and tropomyosin, a combination often associated with motility, in both muscle and nonmuscle cells. Tubulin occurs mainly in the form of microtubules which perform functions ranging from cell shape determination to motility in a wide variety of mammalian cells, as well as in cells in lower vertebrates and invertebrates (for reviews on the cytoskeleton see Stebbings and Hyams, 1979; Tucker, 1979).

Keywords

Hair Cell Actin Filament Outer Hair Cell Thick Filament Actin Bundle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ashmore, J. F., 1987, A fast motile response in guinea pig outer hair cells, J. Physiol., 388:323–347.PubMedGoogle Scholar
  2. Brownell, W. E., Bader, C. R., Bertrand, D. and de Ribaupierre, Y., 1985, Evoked mechanical responses of isolated cochlear hair cells, Science, 227:194–196.PubMedCrossRefGoogle Scholar
  3. Carlisle, L., Thorne, P. R., Zajic, G., Schacht, J., and Altschuler, R. A., 1987, F-actin in the cochlea: differential distributionGoogle Scholar
  4. Drenkhahn, D., Kellner, J., Mannherz, H. G., Groschel-Steward, U., Kendrick-Jones, J. and Scholey, J., 1982, Absence of myosin-like immunoreactivity in stereocilia of cochlear hair cells, Nature, 300:531–532.CrossRefGoogle Scholar
  5. Drenkhahn, D., Schafer, T. and Prinz, M., 1985, Actin, myosin, and associated proteins in the vertebrate auditory and vestibular organs: immunocytochemical and biochemical studies, in: “Auditory Biochemistry”, Drescher, D., ed., Charles C. Thomas, Springfield, Illinois.Google Scholar
  6. EngstrÖm, H. and Engström, B., 1978, Structure of the hairs on cochlear sensory cells, Hearing Res., 1:49–66.CrossRefGoogle Scholar
  7. Flock, A., 1985, Contractile and structural proteins in the auditory organ, in: “Auditory Biochemistry”, Drescher, D., ed., Charles C. Thomas, Springfield, Illinois.Google Scholar
  8. Flock, A., Bretscher, A. and Weber, K., 1982, Immunohistochemical localisation of several cytoskeletal proteins in inner ear sensory and supporting cells, Hearing Res., 6:75–89.CrossRefGoogle Scholar
  9. Furness, D. N. and Hackney, C. M., 1985, Cross-links between stereocilia in the guinea pig cochlea, Hearing Res., 18:177–188.CrossRefGoogle Scholar
  10. Hudspeth, A. J., 1983, Mechanoelectrical transduction by hair cells in the acousticolateralis sensory system, Ann. Rev. Neurosci., 6:187–215.PubMedCrossRefGoogle Scholar
  11. Kimura, R. S., 1975, The ultrastructure of the organ of Corti, Int. Rev. Cytol., 42:173–222.PubMedCrossRefGoogle Scholar
  12. Macartney, J. C., Comis, S. D. and Pickles, J. D., 1980, Is myosin in the cochlea a basis for active motility? Nature, 288:491–492.PubMedCrossRefGoogle Scholar
  13. Slepecky, N. and Chamberlain, S. C., 1985, Immunoelectron-microscopic and immunofluorescent localisation of cytoskeletal and muscle-like contractile proteins in inner ear sensory hair cells, Hearing Res., 20:245–260.CrossRefGoogle Scholar
  14. Stebbings, H. and Hyams, J. S., 1979, Cell Motility, Longman, London.Google Scholar
  15. Tilney, L. G., Egelman, E. H., De Rosier, D. J. and Saunders, J. C., 1983, Actin filaments, stereocilia and hair cells of the bird cochlea II. Packing of actin filaments in the stereocilia and in the cuticular plate and what happens to the organisation when the stereocilia are bent, J. Cell Biol., 96:822–834.PubMedCrossRefGoogle Scholar
  16. Tucker, J. B., 1979, Spatial organization of microtubules, in: “Microtubules”, Roberts, K, Hyams, J. S., eds., Academic Press, London.Google Scholar
  17. Zenner, H. P., Zimmerman, U. and Schmitt, U., 1985, Reversible contraction of isolated mammalian cochlear hair cells, Hearing Res., 18: 127–133.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David N. Furness
    • 1
  • Carole M. Hackney
    • 1
  1. 1.Department of Communication and NeuroscienceUniversity of KeeleKeele, StaffsEngland

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