The Central Projection of Intracellularly Labeled Auditory Nerve Fibers: Morphometric Relationships Between Structural and Physiological Properties



The acoustic receptor cells in the cochlea contact the peripheral processes of primary auditory neurons, called spiral ganglion (SG) cells. The central processes of SG cells bundle together to form the auditory nerve (AN) and project into the cochlear nucleus (CN). Through this pathway, transduced acoustic information is conveyed directly as input to the brain. Essentially all of our knowledge concerning the nature of this input via the AN is derived from the myelinated axon of type-I SG cells. Type I neurons innervate inner hair cells exclusively (Kiang et al., 1982) and represent 90–95% of the SG population (Spoendlin, 1971). Virtually nothing is known about the functional properties of the type-II SG cells which innervate outer hair cells and comprise the remainder of the SG population.


Hair Cell Auditory Nerve Outer Hair Cell Cochlear Nucleus Spiral Ganglion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Benson, T. E., Sento, S., and Ryugo, D. K., 1986, Endbulbs of Held and sperical cells:activity dependent variations in morphology, Soc. Neurosci. Abst., 12:1266.Google Scholar
  2. Borg, E., 1973, On the neuronal organization of the acoustic middle ear reflex:a physiological and anatomical study, Brain Res., 49:101–123.PubMedCrossRefGoogle Scholar
  3. Bourk, T. R., Mielcarz, J. P., and Norris, B. E., 1981, Tonotopic organization of the anteroventral cochlear nucleus of the cat, Hearing Res., 4:215–241.CrossRefGoogle Scholar
  4. Costalupes, J. A., 1985, Representation of tones in noise in the responses of auditory nerve fibers in cats:I Comparison with detection thresholds, J. Neuroscience, 5:3261–3269.Google Scholar
  5. Evans, E. F. and Palmer, A. R., 1980, Relationship between the dynamic range of cochlear nerve fibers and their spontaneous activity, Exp. Brain Res., 40:115–118.PubMedCrossRefGoogle Scholar
  6. Fekete, D. M., Rouiller, E. M., Liberman, M. C. and Ryugo, D. K., 1984, The central projections of intracellularly labeled auditory nerve fibers in cats, J. Comp. Neurol., 229:432–450.PubMedCrossRefGoogle Scholar
  7. Kiang, N. Y. S., 1984, Peripheral neural processing of auditory information, in: “Handbook of Physiology, Section I, Vol. III, Part 2”, Darian-Smith, I., ed., American Physiological Society, Bethesda, 639–674.Google Scholar
  8. Kiang, N. Y. S., Rho, J. M., Northrop, C. C., Liberman, M. C. and Ryugo, D. K., 1982, Hair cell innervation by spiral ganglion cells in adult cat, Science, 217:175–177.PubMedCrossRefGoogle Scholar
  9. Liberman, M. C., 1978, Auditory nerve response from cat raised in a low- noise chamber, J. Acoust. Soc. Am., 63:442–455.PubMedCrossRefGoogle Scholar
  10. Liberman, M. C., 1982, Single neuron labelling in the cat auditory nerve, Science, 216:1239–1241.PubMedCrossRefGoogle Scholar
  11. Lorente de Nó, R., 1981, The primary acoustic nuclei, Raven Press, New-York, NY.Google Scholar
  12. Miller, M. I. and Sach, M. B., 1983, Representation of stop consonants in the discharge pattern of auditory-nerve fibers, J. Acoust. Soc. Am., 74:502–517.PubMedCrossRefGoogle Scholar
  13. Rose, J. E., Galambos, R. and Hughes, J. R., 1959, Microelectrode studies of the cochlear nuclei of the cat, Bull. Johns Hopk. Hos., 104: 211–251.Google Scholar
  14. Rouiller, E. M., Cronin-Schreiber, R., Fekete, D. M. and Ryugo, D. K., 1986, The central projection of intracellularly labeled auditory nerve fibers in cats” An analysis of terminal morphology, J. Comp. Neurol., 249:261–278.PubMedCrossRefGoogle Scholar
  15. Sachs, M. B. and Young, E. D., 1979, Encoding of steady-state vowels in the auditory nerve: representation in terms of discharge rate, J. Acoust. Soc. Am., 66:470–479.PubMedCrossRefGoogle Scholar
  16. Spoendlin, H., 1971, Degeneration behavior of the cochlear nerve, Arch. Klin., Exp. Ohren-Nasen-Kehlkopf., 200:275–291.CrossRefGoogle Scholar
  17. Stevens, S. S. and Davis, H., 1938, Hearing:its psychology and physiology. John Wiley and Sons, NY, NY, 405–407.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  1. 1.Institut de PhysiologieLausanneSwitzerland
  2. 2.Center for Hearing ScienceJohn Hopkins Univ. School of MedicineBaltimoreUSA

Personalised recommendations