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Genetic Variants Affecting the Structure and Function of the Human Red Cell Membrane

  • John C. Parker
  • Lee R. Berkowitz

Abstract

Investigators interested in the plasma membrane have long appreciated the red cell as an object of study. Red cells can be obtained in abundance and easily freed of contamination by other cell types. Mammalian red cells have no membranes other than the plasmalemma, which is easily isolated and purified. The “extracellular space” problem that plagues studies of cell solute and water content is virtually nonexistent. The techniques of making “resealed ghosts” and “inside-out vesicles” have provided ingenious approaches to problems that involve asymmetrical membrane properties. Our understanding of the ultrastructure and organization of lipids and proteins in biological membranes derives largely from the study of human erythrocytes. Much of what we know about the state of water and solutes in cytoplasm, the Na+,K+ pump, the Ca2+ pump, and some coupled, passive transport systems is based on work in red cell preparations.

Keywords

Muscular Dystrophy Sickle Cell Erythrocyte Membrane Duchenne Muscular Dystrophy Myotonic Dystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • John C. Parker
    • 1
  • Lee R. Berkowitz
    • 1
  1. 1.Department of Medicine, School of MedicineUniversity of North CarolinaChapel HillUSA

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