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Studies on the Mechanisms of Changes Produced in the Liver, Thyroid, Pancreas and Kidney by Hypolipidaemic Drugs and DI-(2-Ethylhexyl) Phthalate

  • Chapter
Cells, Membranes, and Disease, Including Renal

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((MSBA,volume 17))

Abstract

With emphasis on methodology, this article concerns effects, in the rat, of LL\(\otimes\) drugs (clofibrate, fenofibrate) and DEEP, administered for up to 18 months. Short-term alterations were also studied in hepatocytes, both freshly isolated and cultured. Alterations were found in the liver, as eozpected, and in several other tissues. Similarly to liver, the kidney proximal tubule showed an initial increase in peroxisomes and then an enlargement of lysosomes which were filled with material staining as for lipofuscin. The pancreas showed exocrine-cell hyperactivity, and with prolonged treatment the islets did not show the hypertrophy normally observed in ageing rats. All the alterations may well relate to alterations in fat metabolism.

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Author information

Authors and Affiliations

  1. Robens Institute of Industrial and Environmental Health and Safety, University of Surrey, GU2 5XH, Guildford, Surrey, UK

    Shirley C. Price, Willis Ochieng, Richard Weaver, Glen Fox, Fiona E. Mitchell, Dawn Chescoe, Jenny Mullervy & Richard H. Hinton

  2. Microstructural Studies Unit, University of Surrey, GU2 5XH, Guildford, Surrey, UK

    Dawn Chescoe & Jenny Mullervy

Authors
  1. Shirley C. Price
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  2. Willis Ochieng
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  3. Richard Weaver
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  4. Glen Fox
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  5. Fiona E. Mitchell
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  6. Dawn Chescoe
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  7. Jenny Mullervy
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  8. Richard H. Hinton
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Editor information

Editors and Affiliations

  1. Guildford Academic Associates, 72 The Chase, GU2 5UL, Guildford, UK

    Eric Reid

  2. University of Cambridge, Cambridge, UK

    G. M. W. Cook  & J. P. Luzio  & 

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© 1987 Plenum Press, New York

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Price, S.C. et al. (1987). Studies on the Mechanisms of Changes Produced in the Liver, Thyroid, Pancreas and Kidney by Hypolipidaemic Drugs and DI-(2-Ethylhexyl) Phthalate. In: Reid, E., Cook, G.M.W., Luzio, J.P. (eds) Cells, Membranes, and Disease, Including Renal. Methodological Surveys in Biochemistry and Analysis, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1283-3_6

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  • DOI: https://doi.org/10.1007/978-1-4684-1283-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1285-7

  • Online ISBN: 978-1-4684-1283-3

  • eBook Packages: Springer Book Archive

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