Abstract
The study of viral pathogenesis has revealed how animals respond to viral infection and the subsequent damage which results. It has become evident that the immune response plays the central role in determining the outcome of viral infection. Many studies have demonstrated the capacity of the immune system to combat viruses with a variety of weapons including interferons, T lymphocytes, natural killer cells, macrophages, antibody, and polymorphonuclear granulocytes (1). The T lymphocytes that respond to viral infection are traditionally recognized as helper, cytotoxic, or supressor cells. In the mouse, each of these groups posess cell surface molecules which confer distinct antigenic phenotypes to these various T cell subsets. Although recent evidence shows there are exceptions to this phenotypic classification of functional activity (2, 3), this approach remains useful in examining the population(s) responding to viral infection and their functions in clearance of the infectious agent from the host.
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© 1987 Plenum Press, New York
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Sussman, M.A., Fleming, J.O., Allen, H., Stohlman, S.A. (1987). Immune Mediated Clearance of JHM Virus from the Central Nervous System. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_49
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