Differential Effects of MHV-4 Infection of Astrocytes and Oligodendrocytes in Vitro
Mouse hepatitis virus, type-4 (strain JHM) has been studied extensively as a model for neurologic disease. Intracerebral infection may lead to fatal encephalomyelitis or may be limited to demyelination (1). Prior to demyelination by myelin stripping macrophages (2), connections between myelin-forming oligodendrocytes and myelin sheaths, not ordinarily visible in the adult nervous system, become apparent (3). Of particular interest, in regard to this observation, demyelination in this model system is followed by remyelination mediated by oligo-dendrocytes (4, 5). However, virus persistence and limited areas of recurrent demyelination may occur (5, 6).
KeywordsGlial Fibrillary Acidic Protein Myelin Basic Protein GPDH Activity Mouse Hepatitis Virus Mouse Astrocyte
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- 8.R.L. Knobler, R. Cole, J. deVellis and M.B.A. Oldstone, The preparation and characterization of primary mouse astrocyte and oligodendrocyte cultures: Fetal age and preparative variations which influence outcome, in preparation (1986).Google Scholar
- 10.R.L. Knobler and M.B.A. Oldstone, The role of host genes and virus-cell tropism in virus induced demyelination: A unique murine experimental model for understanding human demyelinating disease, in: “Viruses and Demyelinating Diseases,” C.A. Mims, M.L. Cuzner and R.E. Kelly, eds., Academic Press, London, (1983).Google Scholar