Abstract
This laboratory has developed over the past several years a rat model for virus-induced1, 2, 3 central nervous system (CNS) disease involving inflammatory demyelinating lesions. The JHM strain of murine hepatitis coronavirus causes an array of neurological diseases differing in complexity depending on factors associated with the age and genetic background of the host4 and the particular JHM virus isolate utilized5. Factors related to the age and genetics of the host associated with susceptibility to disease appear to involve immunological function4, whereas factors related to the virus appear to depend on functional aspects of the E2 envelope glycoprotein4, 6, 7 (Wege et al., this volume).
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Keywords
- Experimental Autoimmune Encephalomyelitis
- Myelin Basic Protein
- Delay Type Hypersensitivity
- Delay Type Hypersensitivity Reaction
- Acute Encephalitis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1987 Plenum Press, New York
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Massa, P.T., Dörries, R., Wege, H., ter Meulen, V. (1987). Analysis and Pathogenetic Significance of Class II MHC (Ia) Antigen Induction on Astrocytes During JHM Coronavirus Infection in Rats. In: Lai, M.M.C., Stohlman, S.A. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 218. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1280-2_25
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