Apolipoproteins Induced by an Antimitotic Agent

  • N. Dousset
  • A. M. Loudet
  • A. Lespine
  • M. Carton
  • L. Douste-Blazy
  • H. Chap
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 210)

Abstract

Hyperlipidemia and inhibition of lipoprotein lipase occur in rabbits after exposure to lethal or not lethal levels of whole-body ionizing radiation (1,2) and after antimitotic agent injection (cyclophosphamide) (3). However, the interrelationships of hyperlipidemia and the lipoprotein metabolism disorders remain obscure.

Keywords

Cholesterol Hydrolysis Urea Lipase Heparin 

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References

  1. 1.
    R. Feliste, N. Dousset, M. Carton and L. Douste-Blazy, Changes in plasma apolipoproteins following whole-body irradiation in rabbit, Radiat. Res. 87: 602 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    N. Dousset, R. Feliste, M. Carton and L. Douste-Blazy, Irradiation-induced free cholesterol accumulation in very-low density lipoproteins. Role of lipoprotein lipase deficiency, Biochim. Biophys. Acta, 794: 444 (1984).PubMedGoogle Scholar
  3. 3.
    A.M. Loudet, N. Dousset, M. Carton and L. Douste-Blazy, Effects of an antimitotic agent (cyclophosphamide) on plasma lipoproteins, Biochem. Pharm. 33: 2961 (1984).PubMedCrossRefGoogle Scholar
  4. 4.
    R.J. Havel, C.J. Fielding, T. Olivecrona, V.G. Shore, P.E. Fielding and T. Egelrud, Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoprotein lipase from different sources, Biochemistry, 12: 1828 (1973).PubMedCrossRefGoogle Scholar
  5. 5.
    R. Ekman and P. Nilsson-Ehle, Effects of apolipoproteins on lipoprotein lipase activity of human adipose tissue, Clin. Chim. Acta, 63: 29 (1975).PubMedCrossRefGoogle Scholar
  6. 6.
    M.W. Huff and D.E. Telford, Characterization and metabolic fate of two very-low-density lipoprotein subfractions separated by heparin-sepharo-se chromatography, Biochim. Biophys. Acta, 796: 251 (1984).PubMedGoogle Scholar
  7. 7.
    Y.L. Marcel, M. Bergseth and A.C. Nestruck, Preparative isoelectric focusing of apolipoproteins C and E from human very low density lipoproteins, Biochim. Biophys. Acta, 573: 175 (1979).PubMedGoogle Scholar
  8. 8.
    J. Boberg, J. Augustin, M.L. Baginsky, P. Tejeda and W.V. Brown, Quantitative determination of hepatic and lipoprotein lipase activities from human post-heparin plasma, J. Lipid Res., 18: 544 (1977).PubMedGoogle Scholar
  9. 9.
    P. Nilsson-Ehle and M.C. Schotz, A stable, radioactive substrate emulsion for assay of lipoprotein lipase, J. Lipid Res., 17: 536 (1976).PubMedGoogle Scholar
  10. 10.
    Y.L. Marcel, C. Vezina, B. Teng and A. Sniderman, Transfer of cholesterol esters between high density lipoproteins and triglyceride rich lipoproteins controlled by a plasma protein factor. Atherosclerosis, 35: 127 (1980).PubMedCrossRefGoogle Scholar
  11. 11.
    V.G. Shore, B. Shore and S.B. Lewis, Isolation and characterization of two threonine-poor apolipoproteins of human plasma high density lipoproteins, Biochemistry, 17: 2174 (1978).PubMedCrossRefGoogle Scholar
  12. 12.
    CL. Malmendier, J. Christophe and J.P. Ameryckx, Separation and partial characterization of new apoproteins from human plasma high density lipoproteins, Clin. Chim. Acta, 99: 167 (1979).PubMedCrossRefGoogle Scholar
  13. 13.
    CL. Malmendier and J.P. Ameryckx, S-peptides: new apoproteins of human high density lipoproteins induced by glucose infusions, Clin. Chim. Acta, 111: 267 (1981).PubMedCrossRefGoogle Scholar
  14. 14.
    E.A. Moon, A.M. Mackinnon and P.J. Barter, Appearance of serum amyloid protein in high-density lipoproteins of rabbits subjected to relatively mild stimuli, Biochim. Biophys. Acta, 796: 354 (1984).PubMedGoogle Scholar
  15. 15.
    G.J. Hopkins, L. B.F. Chang and P.J. Barter, Role of lipid transfers in the formation of a subpopulation of small high density lipoproteins, J. Lipid Res., 26: 218 (1985).PubMedGoogle Scholar
  16. 16.
    R.J. Deckelbaum, S. Eisenberg, Y. Oschry, M. Cooper and C. Blum, Abnormal high density lipoproteins of abetalipoproteinemia: relevance to normal HDL metabolism, J. Lipid Res. 23: 1274 (1982).PubMedGoogle Scholar
  17. 17.
    S. Eisenberg, Preferential enrichment of large-sized very low density lipoprotein populations with transferred cholesteryl esters, J. Lipid Res., 26: 487 (1985).PubMedGoogle Scholar
  18. 18.
    R.J. Deckelbaum, T. Oliveerona and S. Eisenberg, Plasma lipoproteins in hyperlipidemia: roles of neutral lipid exchange and lipase. In Treatment of hyperlipoproteinemia, 1984, pp.85–93. Ed. L.A. Carlson and A.G. Olsson, Raven Press, New York.Google Scholar
  19. 19.
    R. Feliste, N. Dousset, M. Carton and L. Douste-Blazy, Effects of threonine-poor apolipoproteins on post-heparin plasma hepatic triacyl-glycerol lipase and lipoprotein lipase, Biochim. Biophys. Acta, 712: 326 (1982).PubMedGoogle Scholar
  20. 20.
    A. Van Tol, T. Van Gent and H. Jansen, Degradation of high density lipoprotein by heparin-releasable liver lipase, Biochem. Biophys. Res. Commun. 94: 101 (1980).PubMedCrossRefGoogle Scholar
  21. 21.
    T. Murase and H. Itakura, Accumulation of intermediate density lipoprotein in plasma after intravenous administration of hepatic triglyceride lipase antibody in rats, Atherosclerosis, 39: 293 (1981).PubMedCrossRefGoogle Scholar
  22. 22.
    J. Grosser, O. Schrecker and H. Greten, Function of hepatic triglyceride lipase in lipoprotein metabolism, J. Lipid Res., 22: 437 (1981).PubMedGoogle Scholar
  23. 23.
    A. M. Loudet, N. Dousset, B. Perret, M. Ierides, M. Carton and L. Douste-Blazy, Triacylglycerol increase in plasma very low density lipoproteins in cyclophosphamide-treated rabbit: relationship with cholesteryl ester transfer activity, Biochim. Biophys. Acta, 836: 376 (1985).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • N. Dousset
    • 1
  • A. M. Loudet
    • 1
  • A. Lespine
    • 1
  • M. Carton
    • 2
  • L. Douste-Blazy
    • 1
  • H. Chap
    • 1
  1. 1.INSERM Unité 101Hôpital PurpanToulouse CédexFrance
  2. 2.Centre Claudius RegaudToulouse CédexFrance

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