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Type III Hyperlipoproteinemia: A Focus on Lipoprotein Receptor-Apolipoprotein E2 Interactions

  • Thomas L. Innerarity
  • David Y. Hui
  • Thomas P. Bersot
  • Robert W. Mahley
Part of the Advances in Experimetal Medicine and Biology book series (AEMB, volume 201)

Abstract

Type III hyperlipoproteinemia is a genetic abnormality characterized by elevated levels of plasma cholesterol and triglycerides and by the presence of cholesterol-enriched β-migrating very low density lipoproteins (β-VLDL). Patients suffering from this abnormality develop tuberous xanthomas and premature atherosclerosis. The expression of the disease depends upon the interaction of a known apoprotein genotype with other genetic and/or environmental factors; thus, type III hyperlipoproteinemia is an especially good model for furthering our understanding of the interplay of genetic and environmental factors in the regulation of lipoprotein metabolism and the development of atherosclerosis.

Keywords

Receptor Binding Lipoprotein Receptor Receptor Binding Domain Chylomicron Remnant Familial Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Thomas L. Innerarity
    • 1
  • David Y. Hui
    • 1
  • Thomas P. Bersot
    • 1
  • Robert W. Mahley
    • 1
  1. 1.Gladstone Foundation Laboratories for Cardiovascular Disease Cardiovascular Research Institute, Departments of Pathology and MedicineUniversity of CaliforniaSan FranciscoUSA

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