Cognitive Enhancers in Alzheimer’s Disease

  • Neal R. Cutler
  • Prem K. Narang

Abstract

Cognitive enhancers are compounds that have been purported to improve memory. Several drugs from various classes have been investigated clinically in the elderly population with different types of dementia. It is important to clarify that the dose-response relationships with these agents in the elderly population are almost nonexistent. This difficulty associated with the clinical trials in dementia patients is primarily due to problems related to quantification of the drug effect, as neuropsychological assessments have a large degree of associated measurement error. Pharmacokinetic and dynamic studies with these drugs have been few. Therefore, rather than choosing to discuss kinetics, as expected from the contributions in this part, we have decided to address methodological issues that pertain to all agents being evaluated in the elderly with some form of dementia.

Keywords

Dopamine Serotonin Choline Acetylcholine Vasopressin 

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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Neal R. Cutler
    • 1
  • Prem K. Narang
    • 2
  1. 1.Department of Geriatrics, Cedars-Sinai Medical CenterUniversity of California-Los Angeles School of MedicineLos AngelesUSA
  2. 2.Clinical Pharmacokinetics Research Laboratory, Pharmacy Department, Clinical CenterNational Institutes of HealthBethesdaUSA

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