Ectoenzymes of Nucleotide Metabolism on Human Lymphoid Cells
Human lymphoid cells, e.g. normal peripheral blood lymphocytes, leukemic cells and permanent lymphoblastoid cell lines show extreme variations in the expression of nucleotide degrading ectoenzymes 1,2,3 Up to now this has mainly been studied for ecto-5′-nucleotidase (5′-N). On the other hand, a common expression of 5′-N and the common ALL-antigen (cALLA) frequently observed in certain forms of acute leukemias2 is not reflected by a close association of these two surface markers on the plasmamembrane level. In search for components which might be more closely connected with 5′-N we studied other ectoenzymes on the surface of lymphoid cells.
KeywordsLymphoma Leukemia Adenosine Pyrimidine Purine
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- 1.L.P. Thompson, A. Saxon, R.D. O’Connor and R.I. Fox, Ecto-5′-nucleotidase activity in human T cell subsets. Decreased numbers of ecto-5′-nucleotidase positive cells from both: OKT 4 + and OKT 8+ cells in patients with hypogammaglobulinemia, J.Clin.Invest. 71: 892–899 (1983)PubMedCrossRefGoogle Scholar