Abstract
Adenosine formed by the heart has been proposed to participate in the metabolic regulation of coronary blood flow [1]. Adenosine can be formed from AMP by action of 5′-nucleotidase or alkaline or acid phosphatase, or from S-adenosylhomocysteine by means of S-adenosyl-homocysteine hydrolase. A 5′-Nucleotidase in the heart was shown by histochemical studies to be associated with myocardial cell membrane [2], and functional studies indicate the enzyme to be an ectoenzyme [3].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J. Sehrader, Site of action and production of adenosine in the heart, in: “Purinergic Receptor,” G. Burnstock, ed., Chapman and Hall, London (1981)
R. Rubio, R. M. Berne, and J. G. Dobson, Jr., Site of adenosine production in cardiac and skeletal muscle, Am. J Physiol. 225: 938 (1973)
H. P. Bear, and G. I. Drummond, Catabolism of adenine nucleotides by the isolated perfused rat heart, Proc. Soc. Exp. Biol. Med. 127: 33 (1968)
W. Shütz, J. Schrader, and E. Gerlach, Different sites of adenosine formation in the heart, Am. J. Physiol. 240: H963 (1981)
J. M. Lowenstein, M.-K. Yu, and Y. Naito, Regulation of adenosine metabolism by 5′-nucleotidase, in: “Regulatory Function of Adenosine,” R. M. Berne, T. W. Rall, and R. Rubio, ed., Martinus Nijhoff, Boston (1983)
R. Itoh, and J. Oka, Evidence for existence of a cytosol 5′-nucleotidase in chicken heart, Comp. Biochem. Physiol, (in press)
Y. Naito, and K. Tsushima, Cytosol 5′-nucleotidase from chicken liver, Biochim. Biophys. Acta 438: 159 (1976)
R. Itoh, Purification and some properties of cytosol 5′-nucleotidase from rat liver, Biochim. Biophys. Acta 651: 402 (1981)
D. E. Atkinson, The energy charge of adenylate pool as a regulatory parameter, Biochemistry 7: 4030 (1968)
R. Eisenthal, and A. Cornish-Bowden, The direct linear plot, Biochem. J. 139: 715 (1974)
D. E. Atkinson, “Cellular Energy Metabolism and its Regulation,” Academic Press, London (1977)
A. G. Chapman, and D. E. Atkinson, Stabilization of adenylate energy charge by the adenylate deaminase reaction, J. Biol. Chem. 248: 8309 (1973)
A. G. Chapman, A. L. Millar, and D. E. Atkinson, Role of adenylate deaminase reaction in regulation of adenine nucleotide metabolism in Ehrlich ascites tumor cells, Cancer. Res. 36: 1144 (1976)
R. B. Jennings, K. A. Reimer, M. L. Hill, and S. E. Mayer, Total ischemia in dog heart in vitro, Circ. Res. 49: 892 (1981)
J. L. Swain, R. L. Sabina, P. A. McHale, J. C. Greenfield, and H. W. Holmes, Prolonged myocardial nucleotide depletion after brief ischemia in open-chest dog, Am. J. Physiol. 242: H8l8 (1982)
C-s Liang, and J. M. Lowenstein, Metabolic control of the circulation, J. Clin. Invest. 62: 1029 (1978)
R. Itoh, Regulation of cytosol 5′-nucleotidase by adenylate energy charge, Biochim. Biophys. Acta 659: 31 (1981)
C. Solano, and C. J. Coffee, Differential response of AMP deaminase isozymes to changes in the adenylate energy charge, Biochem. Biophys. Res. Commun. 85: 564 (1978)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Itoh, R., Oka, J., Ozasa, H. (1986). Regulation of the Cytosol 5′-Nucleotidase of the Heart by Adenylate Energy Charge. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_47
Download citation
DOI: https://doi.org/10.1007/978-1-4684-1248-2_47
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-1250-5
Online ISBN: 978-1-4684-1248-2
eBook Packages: Springer Book Archive