S-Adenosylmethionine Metabolism as a Target for Adenosine Toxicity
Adenosine exerts marked cytostatic and cytotoxic actions to mammalian cells. The nucleoside has been reported to inhibit pyrimidine nucleotide synthesis, to foster cyclic AMP accumulation and to cause the accumulation of S-adenosylhomocysteine (AdoHcy).1,2 Adenosine kinase (EC 184.108.40.206) deficient mammalian cells do not phosphorylate adenosine, but adenosine still blocks their growth, and this Is not reversed by addition of uridine. 2,3 Thus, adenosine may exert toxicity at the nucleoside level. Also, some adenosine analogs are cytotoxic without being converted to nucleotides.4
KeywordsAdenosine Kinase AdoHcy Hydrolase Human Histiocytic Lymphoma Nucleoside Level AdoMet Synthetase
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