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The Effect of Phosphonoformic acid on Wild type and Mutant S49 Cell Lines

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Purine and Pyrimidine Metabolism in Man V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 195B))

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Abstract

Phosphonoformic acid was synthesized In 1924 by Nylen (1) and has been investigated recently as an antiviral agent because of its inhibition of viral DNA polymerase (2,3,4). Herpes simplex virus polymerase activity is quite sensitive to PFA Inhibition (Ki=3.5 uM) (2). Partially purified mammalian (calf thymus) DNA polymerase is less sensitive to PFA Inhibition, and this sensitivity depends on the enzyme concentration (K.>3.5 uM) (2).

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References

  1. P. Nylen, Chem. Ber. 57B: 1023 (1924).

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  2. E, Helgstrand et al. Science 201: 819 (1978).

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  6. D. A. Albert and L. J. Gudas, J. Blol. Chem. 260: 679 (1985).

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Chicago, Chicago, IL, 60637, USA

    Daniel A. Albert & Lorraine J. Gudas

  2. Department of Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA

    Daniel A. Albert & Lorraine J. Gudas

Authors
  1. Daniel A. Albert
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  2. Lorraine J. Gudas
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    W. L. Nyhan

  2. Scripps Clinic and Research Foundation, La Jolla, California, USA

    L. F. Thompson

  3. M. R. C. Clinical Research Center, Harrow, UK

    R. W. E. Watts

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© 1986 Plenum Press, New York

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Albert, D.A., Gudas, L.J. (1986). The Effect of Phosphonoformic acid on Wild type and Mutant S49 Cell Lines. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_28

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  • DOI: https://doi.org/10.1007/978-1-4684-1248-2_28

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-1250-5

  • Online ISBN: 978-1-4684-1248-2

  • eBook Packages: Springer Book Archive

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