Skip to main content
SpringerLink
Log in

Adenosine Receptors on Human Lymphocytes

  • Chapter
  • First Online:
Purine and Pyrimidine Metabolism in Man V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 195B))

Abstract

Evidence is accumulating that adenosine functions as an important immunoregulatory autacoid (1,2). Adenosine inhibits the mitotic response of human lymphocytes (3,4), lymphocyte-mediated cytolysis (5), superoxide anion generation by neutrophils (6), platelet aggregation (7) and mediator release from human basophils (8-10). The nucleoside has been shown to modulate a number of T lymphocyte responses (11,12). Adenosine has been implicated in the pathophysiology of patients with severe combined immune deficiency associated with a deficit of adenosine deaminase (13), in systemic lupus erythematosus (14), in bronchial asthma (15,16) and in a variety of cardiovascular diseases (17).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. G. Marone, R. Petracca, and M. Condorelli, Adenosine receptors on human inflammatory cells, in: Purine Metabolism in Man — IV — Part A: Clinical and Therapeutic Aspects; Regulatory Mechanisms, C.H.M.M. De Bruijn, H.A. Simmonds, and M.M. Müller, eds., Plenum Press, New York, p. 501 (1984).

    Chapter  Google Scholar 

  2. G. Marone, R. Petracca, and S. Yigorita, Adenosine receptors on human inflammatory cells, Int. Archs. Allergy appl. Immunol. 77: 259 (1985).

    Article  CAS  Google Scholar 

  3. R. Hirschhorn, J. Grossman, and G. Weissmann, Effect of cyclic 3′,5′-adenosine monophosphate and theophylline on lymphocyte transformation, Proc. Soc. Exp. Biol. Med. 133: 1361 (1970).

    Article  CAS  Google Scholar 

  4. D.A. Carson, and J.E. Seegniller, Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis, J. Clin. Invest. 57: 274 (1976).

    Article  CAS  Google Scholar 

  5. G. Wolberg, T.P. Zimmerman, K. Hiemstra, M. Winston, and L.C. Chu, Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate, Science 1872 957 (1975).

    Article  Google Scholar 

  6. B.N. Cronstein, S.B. Kramer, G. Weissmann, and R. Hirschhorn, Adenosine: a physiological modulator of superoxide anion generation by human neutrophils, J. Exp. Med. 158: 1160 (1983).

    Article  CAS  Google Scholar 

  7. G. Marone, S. Quattrin, M. Masturzo, O. Finizio, A. Genovese, and M. Condorelli, Adenosin-rezeptoren von menschlichen plaettchen: Charakterisierung des A2/Ra rezeptors und des P-lokus, in: Thrombose-und Hämostaseforschung 1984, E.A. Beck, ed., F.K. Schattauer Verlag, Stuttgart, p. 221 (1984).

    Google Scholar 

  8. G. Marone, S.R. Findlay, and L.M. Lichtenstein, Adenosine receptor on human basophils: modulation of histamine release, J. Immunol. 123: 1473 (1979).

    CAS  PubMed  Google Scholar 

  9. G. Marone, A. Kagey-Sobotka, and L.M. Lichtenstein, IgE-mediated histamine release from human basophils: differences between antigen E-and anti-IgE-induced secretion, Int. Archs. Allergy appl. Immunol. 65: 339 (1981).

    Article  CAS  Google Scholar 

  10. G. Marone, S. Vigorita, C. Antonelli, G. Torella, A. Genovese, and M. Condorelli, Evidence for an adenosine A2/Ra receptor on human basophils, Life Sci. 36: 339 (1985).

    Article  CAS  Google Scholar 

  11. R.E. Birch, and S.H. Polmar, Induction of Fcγ receptors on a subpopulation of human T lymphocytes by adenosine and impromidine, an H2-histamine agonist, Cell. Immunol. 57: 455 (1981).

    Article  CAS  Google Scholar 

  12. G.M. Kammer, and S.A. Rudolph, Regulation of human T lymphocyte surface antigen mobility by purinergic receptors, J. Immunol. 133: 3298 (1984).

    CAS  PubMed  Google Scholar 

  13. R. Hirschhorn, Adenosine deaminase deficiency and immunodeficiencies, Fed. Proc. 36: 2166 (1977).

    CAS  PubMed  Google Scholar 

  14. R. Mandler, R.E. Birch, S.H. Polmar, G.M. Kammer, and S.A. Rudolph, Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus, Proc. Natl. Acad. Sci. USA 79: 7542 (1982).

    Article  CAS  Google Scholar 

  15. R. Ronchetti, N. Lucarini, P. Lucarelli, F. Martinez, F. Maorì, E. Carapella, and E. Bottini, A genetic basis for heterogeneity of asthma syndrome in pediatric ages: adenosine deaminase phenotypes, J. Allergy Clin. Immunol. 74: 81 (1984).

    Article  CAS  Google Scholar 

  16. S.T. Holgate, J.S. Mann, and M.J. Cushley, Adenosine as a bronchoconstrictor mediator in asthma and its antagonism by methylxanthines, J. All. Clin. Immunol. 74: 302 (1984).

    Article  CAS  Google Scholar 

  17. R.M. Berne, The role of adenosine in the regulation of coronary blood flow, Circ. Res. 47: 807 (1980).

    Article  CAS  Google Scholar 

  18. G. Marone, M. Plaut, and L.M. Lichtenstein, Characterization of a specific adenosine receptor on human lymphocytes, J. Immunol. 121: 2153 (1978).

    CAS  PubMed  Google Scholar 

  19. J. Wolff, C. Londos, and D.M.F. Cooper, Adenosine receptors and the regulation of adenylate cyclase, in: Advances in Cyclic Nucleotide Research, vol. 14, J.E. Dumont, P. Greengard, and G.A. Robison, eds., Raven Press, New York, p. 199 (1981).

    Google Scholar 

  20. C. Londos, and J. Wolff, Two distinct adenosine-sensitive sites on adenylate cyclase, Proc. Natl. Acad. Sci. USA 74: 5482 (1977).

    Article  CAS  Google Scholar 

  21. D. Van Calker, M. Müller, and B. Hamprecht, Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells, Nature 276: 839 (1978).

    Article  Google Scholar 

  22. C. Londos, D.M.F. Cooper, and J. Wolff, Subclasses of external adenosine receptors, Proc. Natl. Acad. Sci. USA 77: 2551 (1980).

    Article  CAS  Google Scholar 

  23. G. Marone, L.L. Thomas, and L.M. Lichtenstein, The role of agonists that activate adenylate cyclase in the control of cAMP metabolism and enzyme release by human polymorphonuclear leukocytes, J. Immunol. 125: 2277 (1980).

    CAS  PubMed  Google Scholar 

  24. G. Marone, L.M. Lichtenstein, and M. Plaut, Hydrocortisone and human lymphocytes: increases in cyclic adenosine 3′;5′-monophosphate and potentiation of adenylate cyclase-activating agents, J. Pharmacol. Exp. Ther. 215: 469 (1980).

    CAS  PubMed  Google Scholar 

  25. M. Plaut, G. Marone, and E. Gillespie, The role of cyclic AMP in modulating cytotoxic T lymphocytes. II. Sequential changes during culture in responsiveness of cytotoxic lymphocytes to cyclic AMP-active agents, J. Immunol. 1312 2945 (1983).

    Google Scholar 

  26. P.M. Lad, T.B. Nielsen, C. Londos, M.S. Preston, and M. Rodbell, Independent mechanisms of adenosine activation and inhibition of the turkey erythrocyte adenylate cyclase system, J. Biol. Chem. 255: 10841 (1980).

    CAS  PubMed  Google Scholar 

  27. G. Marone, A. Kagey-Sobotka, and L.M. Lichtenstein, Effects of arachidonic acid and its metabolites on antigen-induced histamine release from human basophils in vitro, J. Immunol. 123: 1669 (1979).

    CAS  PubMed  Google Scholar 

  28. B.B. Fredholm, Release of adenosine from rat lung by antigen and compound 48/80, Acta Physiol. Scand. 111: 507 (1981).

    Article  CAS  Google Scholar 

  29. D.L. Marquardt, H.E. Gruber, and S.L. Wasserman, Adenosine release from stimulated mast cells, Proc. Natl. Acad. Sci. USA 81: 6192 (1984).

    Article  CAS  Google Scholar 

  30. A. Sollevi, J. Ostergren, P. Hjemdahl, B.B. Fredholm, and B. Fagrell, The effect of dipyridamole on plasma adenosine levels and skin micro-circulation in man, in: Purine Metabolism in Man-IV-Part A: Clinical and Therapeutics Aspects; Regulatory Mechanisms, C.H.M.M. De Bruijn, H.A. Simmonds, and M.M. Müller, eds., Plenum Press, New York, p. 547 (1984).

    Chapter  Google Scholar 

  31. G. Marone, The role of basophils and mast cells in the pathogenesis of pulmonary diseases, Int. Archs. Allergy appl. Immunol. 76 (suppl. 1): 70 (1985).

    Article  Google Scholar 

  32. G. Marone, G. Ambrosio, D. Bonaduce, A. Genovese, M. Triggiani, and M. Condorelli, Inhibition of IgE-mediated histamine release from human basophils and mast cells by fenoterol, Int. Archs. Allergy appl. Immunol. 74: 356 (1984).

    Article  CAS  Google Scholar 

  33. G. Marone, M. Columbo, L. Soppelsa, and M. Condorelli, The mechanism of basophil histamine release induced by pepstatin A, J. Immunol. 133: 1542 (1984).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Naples, II School of Medicine, Via S. Pansini 5, 80131, Naples, Italy

    Gianni Marone, Sergio Vigorita, Massimo Triggiani & Mario Condorelli

Authors
  1. Gianni Marone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sergio Vigorita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Massimo Triggiani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mario Condorelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    W. L. Nyhan

  2. Scripps Clinic and Research Foundation, La Jolla, California, USA

    L. F. Thompson

  3. M. R. C. Clinical Research Center, Harrow, UK

    R. W. E. Watts

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Marone, G., Vigorita, S., Triggiani, M., Condorelli, M. (1986). Adenosine Receptors on Human Lymphocytes. In: Nyhan, W.L., Thompson, L.F., Watts, R.W.E. (eds) Purine and Pyrimidine Metabolism in Man V. Advances in Experimental Medicine and Biology, vol 195B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1248-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-1248-2_2

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-1250-5

  • Online ISBN: 978-1-4684-1248-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation