Alteration of Ribonucleotide and Deoxyribonucleotide Metabolism by Interferon in Human B- Lymphoblastoid Cells

  • Jerzy Barankiewicz
  • Chaim Kaplinsky
  • Amos Cohen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 131)

Abstract

Inhibition of cell growth and proliferation by interferon has been studied intensively1-3. Although it was believed that the suppression of cell proliferation by interferon is associated with inhibition of thymidine kinase activity, recent studies using thymidine kinase deficient cells showed that activity of this enzyme is not crucial for interferon action4. Therefore, it was of great interest to study effects of interferon on other reactions of both ribonucleotide and deoxyribonucleotide metabolism, which possibly could explain inhibitory action of interferon on nucleic acid synthesis.

Keywords

HPLC Adenosine Interferon Adenine Pyrimidine 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Jerzy Barankiewicz
    • 1
  • Chaim Kaplinsky
    • 1
  • Amos Cohen
    • 1
  1. 1.Division of Immunology Research InstituteThe Hospital for Sick ChildrenTorontoCanada

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