Abstract
Menstrual cycle physiology and sexual behavior were studied in female cynomolgus monkeys following short- and long-term administration of RU 486 and a placebo, given by gavage at the end of the cycle. Some evidence of menstrual cycle irregularity associated with extended follicular phases was found in two of four females treated with RU 486, but interpretation is difficult because of the small number of subjects. No effect of RU 486 was apparent on the sexual behavior of the females or of the males with which they were tested.
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References
Adams, D. B., Gold, A. R. and Burt, A. D., 1978, Rise in female-initiated sexual activity at ovulation and its supression by oral contraceptives, New Eng. J. Med., 299: 1145–1150.
Beach, F. A., 1976a, Cross-species comparisons and the human heritage, Arch. Sex. Behay., 5: 469–485.
Beach, F. A., 1976b, Hormonal control of sex-related behavior, in: “Human Sexuality in Four Perspectives,” F. A. Beach, ed., Johns Hopkins University Press, Baltimore.
Deraedt, R., Bonnat, C., Busigny, M., Chatelet, P., Cousty, C., Mouren, M., Philibert, D., Pottier, J., and Salmon, J., Pharmacokinetics of RU 486, this volume.
Genazzani, A. R., Devoto, M. C., Cianchetti, C., Pintor, C., Facchinetti, F., Mangoni, A. and Fioretti, P., 1978, Possible correlations between plasma androgen variations during the menstrual cycle and sexual behaviour in the human female, in: “Clinical Psychoneuroendocrinology in Reproduction,” L. Carenza, P. Pancheri and L. Zichella, eds., Academic Press, New York.
Germain, G., Philibert, D., Pottier, J., Mouren, M., Baulieu, E. E., and Sureau, G., Effects of an antiprogesterone (RU 486) on the time-course of the natural cycle and gestation in intact cynomolgus monkeys (Macaca fascicularis), this volume.
Healy, D. L., Baulieu, E. E. and Hodgen, G. D., 1983a, Induction of menstruation by an anti-progesterone steroid (RU 486) in primates: site of action, dose-response relationships and hormonal effects., Fertil., Steril., 40: 253–257.
Healy, D. L., Chrousos, G. P., Schulte, H. M., Williams, R. F., Gold. P. W., Baulieu, E. E., and Hodgen, G. D., 1983b, Pituitary and adrenal responses to the antiprogesterone and antiglucocorticoid steroid RU 486 in primates, J. Clin. Endocrinol. Metab., 57: 863–865.
Kreitmann-Gimbal, B., Kreitmann, 0. L., Sopelak, V. M., Baulieu, E. E. and Hodgen, G. D., 1984, Menstrual induction in the primate fertile and non-fertile cycle: Anti-progesterone RU 486 binds to endometrial progesterone receptors without affecting luteal cells, J. Ster. Biochem., 19:1125, abstract no. 336.
Luttge, W. G., 1971, The role of gonadal hormones in the sexual behavior of the rhesus monkey and human: A literature survey, Arch. Sex. Behay., 1: 61–88.
Nieman, L. K., Healy, D. L., Spitz, I. M., Merriam, G. R., Hardin, C. W., Loriaux, D. L. and Chrousos, G. P., Induction of menstruation in normal women by a single dose of the antiprogesterone steroid RU 486, this volume.
Zumpe, D. and Michael, R. P., 1983, A comparison of the behavior of Macaca fascicularis and Macaca mulatta in relation to the menstrual cycle, Am. J. Primatol., 4: 55–72.
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© 1985 Plenum Press, New York
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Nadler, R.D., Roth-Meyer, C., Baulieu, EE. (1985). Behavioral and Endocrine Consequences of Long-Term Antiprogesterone (RU 486) Administration to Cynomolgus Monkeys: Preliminary Results. In: Baulieu, EE., Segal, S.J. (eds) The Antiprogestin Steroid RU 486 and Human Fertility Control. Reproductive Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-1242-0_14
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DOI: https://doi.org/10.1007/978-1-4684-1242-0_14
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-1244-4
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