Enzymatic Production of Secondary Metabolites

  • H. Kleinkauf
  • H. V. Döhren
Part of the NATO ASI Series book series (NSSA, volume 87)


In a recent discussion of the microbiological production of Pharmaceuticals, it was pointed out that process improvement in the case of secondary metabolites can hardly be achieved by single gene manipulation, since between 10 and 30 structural genes contribute by the joint action of their products to the biosynthesis of one single complex compound.1 Reviewing the last 15 years progress on biosynthetic pathways with special reference to gene products or enzymes, we have found many instances of a new type of enzyme organization, i.e. one organized into multienzymes2 (table 1). A more detailed analysis shows that multienzymes may catalyze up to 8 consecutive reaction steps (table 2).


Bacillus Licheniformis Dissolve Oxygen Tension Dipeptide Cyclization Bacillus Polymyxa Continuous Procedure 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • H. Kleinkauf
    • 1
  • H. V. Döhren
    • 1
  1. 1.Institut für Biochemie und Molekulare BiologieTechnischen Universität BerlinBerlin 10 (West)Germany

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