Abstract
Early hypotheses about the role of basal ganglia in motor behaviour have been strongly influenced by clinicopathological studies that revealed a correlation between lesions of the nuclei of basal ganglia and a variety of disorders of movement such as akinesia, tremor, involuntary movements and disturbances of posture, equilibrium and muscle tone (for ref. Jung and Hassler, 1960; DeLong and Georgopoulos, 1981). Clinical and experimental studies over the last twenty years have confirmed the importance of basal ganglia in motor behaviour and suggested a participation of these structures in control of aspects of social or cognitive behaviour (Divac, 1977; Iversen, 1977; Oberg and Divac, 1977; Cools et al., 1981; Cools et al., 1984b).
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References
Anden, N. E. and Stock, G., 1973, Inhibitory effect of gamma hydroxybutyric acid and gamma aminobutyric acid on the dopamine cells in the substantia nigra, Naunyn-Schmiedeberg’s Arch. Pharmacol., 279:89.
Cools, A. R., 1980, Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: facilitation of processes involved in selecting the best strategy in a stressful situation, Beh. Brain Res., 1:361.
Cools, A. R., van den Bercken, J., Horstink, M., van Spaendonck, K., and Berger, H., 1981, The basal ganglia and the programming of behaviour, TINS, 124.
Cools, A. R., Jaspers, R., Kolasiewicz, W., Sontag, K. -H., andWolfarth, S., 1983, Substantia nigra as a station that not only transmits, but also transforms, incoming signals for its behavioural expression: striatal dopamine and GABAmediated responses of pars reticulata neurons, Beh. Brain Res., 7:39.
Cools, A. R., Jaspers, R., Schwarz, M., Sontag, K.-H. Vrijmoed-de Vries, M. and van Hoof, J., 1984a, Caudate nucleus and disorders in switching motor programmes. Adv. Beh. Biol., (in press).
Cools, A. R. van den Bercken, J. Horstink, M.van Spaendonck, K. and Berger, H, 1984b, Cognitive and motor shifting aptitude disorders in Parkinson’s disease, J Neurol. Neurosurg. Psychiatry, (in press).
DeLong, M. R., and Georgopoulos, A. P., 1981, Motor functions of the basal ganglia, “Handbook of Physiology,” Section 1, Vol.II, V. B. Brooks, (ed)., Bethesda, Maryland.
DiChiara, G., Porceddu, M. L., Imperato, A., and Morelli, M., 1981, Role of GABA neurones in the expression of striatal motor functions, m: “GABA and the Basal Ganglia”. Advances in Biochem. Psychopharmacol., Vol. 30, G. DiChiara, and G.I. Gessa, eds.. Raven Press, New York.
DiChiara, G.., Olianas, M., Del Fiacco, M., Spano P. F., andTagliamonte, A., 1977, Intranigral kainic acid is evidence that nigral non-dopaminergic neurons control posture. Nature (London), 268:743.
Divac, I., 1977, Does the neostriatum operate as a functional entity? in: “Psychobiology of the Striatum,” A. R. Cools, A. H. M. Lohmann, and J. H. L. van den Bercken, eds., Elsevier, Amsterdam.
Dray, A., 1979, The striatum and substantia nigra: a commentary on their relationship, Neurosci., 4:1407.
Flowers, K. A., 1976, Visual ’closed’ loop and ’open’ loopcharacteristics of voluntary movement in patients with parkinsonism and intention tremor. Brain, 99:269.
Flowers, K. A., 1978, Lack of prediction in the motor behaviour of parkinsonism. Brain, 101:35.
Gale, K., and Casu, M., 1981, Dynamic utilization of GABA insubstantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioural implications, Mol. Cell. Biochem., 39:369.
Garcia-Munoz, M. Nicolaou, N. M., Tulloch, I. F., Wright, A. K., and Arbuthnott, G. W., 1977, Feedback loop or output pathway in striato-nigral fibers. Nature (London), 265:363.
Goodwin, G. M., Hulliger, M., and Matthews, P. B. C., 1975, the effects of fusimotor stimulation during small amplitude stretching on the frequency-response of the primary ending of the mammalian muscle spindle, J. Physiol., 253:175.
Hallett, M., and Koshbin, S., 1980, A physiological mechanism of bradykinesia. Brain, 103:301.
Hopkins, D. A., and Niessen, L. W., 1976, Substantia nigraprojections to the reticular formation, superior colliculus and central gray in the rat, cat and monkey, Neurosci. Lett., 2:253.
Home, D. J., 1973, Sensorimotor control in parkinsonism, J. Neurol. Neurosurg. Psychiatry, 36: 742.
Hornykiewicz O., 1963, Die topische Lokalisation und das Verhalten von Noradrenalin xind Dopamin (3-Hydroxytyramin) in der Substantia nigra des normalen und parkinsonkranken MenschenWien Klin. Wschr., 75:309.
Hulliger, M., 1981, Muscle spindle afferent units. Functionalproperties with possible significance in spasticityin: “Therapie der Spastik,” H. J. Bauer, W. P. Koella, and A. Struppler, eds., Verlag für angewandte Wissenschaften, München.
Ilinsky, J. A. Kultas-Ilinsky, K., and Smith, K. R., 1982,Organization of basal ganglia inputs to the thalamus. A light and electron microscopic study in the cat, Appl. Neurophysiol., 45:230.
Iversen, S. D., 1977, Brain dopamine systems and behaviourin: “Handbook of Psychopharmacology,” Vol. 8, L. L. Iversen, S. D. Iversen, and S. H. Snyder, eds.. Plenum, New York.
Jung, R.,, and Hassler, R., 1960, The extrapyramidal motor system, m: “Handbook of Physiology,” Sect. 1, Vol. II, J. Field, H. W. Magoun and V. E. Hall, eds.. Am. Physiol. Soc., Washington, D.C.
Kilpatrick, J. C., Starr, M. S., James, T. A., and MacLeod, N. K., 1981, Evidence for the involvement of nigrothalamic GABAneurones in circling behaviour in the rat, in: “GABA andthe Basal Ganglia.” Advances in Biochem. Psychopharmacol., Vol. 30, G. DiChiara, and G. L. Gessa, eds.. Raven Press, New York.
Kultas-Ilinsky, K. Ilinsky, J. A., Massopust, L. C., Young, P. A., and Smith, K. B., 1978, Nigrothalamic pathway in the cat demonstrated by autoradiography and electron microscopyExpl. Brain Res., 33:481.
Marsden, C. D., 1980, The enigma of the basal ganglia and movementTINS, 3:284.
Oberg, R. G. E., and Divac, I., 1979, ’Cognitive’ functions of the neostriatum, m: “The Neostriatum,” I. Divac and R. G. E. Oberg, eds., Pergamon, Oxford.
Olianas, M. C., DeMontis, G. M., Conçu, A., Tagliamonte, A., and DiChiara, G., 1978a, Intranigral kainic acid: Evidence for nigral non-dopaminergic neurons controlling posture and behaviour in a manner opposite to the dopaminergic onesEurop. J.Pharmacol., 49:223.
Olianas, M. C., DeMontis, G. M., Mulas, G., and Tagliamonte, A.,1978b, The striatal dopaminergic function is mediated by the inhibition of a nigral, non-dopaminergic neuronal system via strionigral GABAergic pathwayEurop. J. Pharmacol., 49:233.
Reavill, C., Leigh, N., Jenner, P., and Marsden, C. P., 1981, Critical role of midbrain reticular formation in the expression of dopamine-mediated circling behaviour, m: “GABA and the Basal Ganglia”. Advances in Biochem. Psychopharmacol., G. DiChiara, and G. L. Gessa, eds.. Raven Press, New York.
Rinvik, E., Grofova, J., and Ottersen, O. P., 1976, Demonstration of nigrotectal and nigroreticular projections in the cat by axonal transport of proteins.Brain Res., 112:388.
Scheel-kruger, j., 1984, the gaba receptor and animal behaviour in: “gaba receptors,” s. J. Enna, ed., hvimana press, clifton, new jersey, (in press).
Scheel-Kruger, J., Mageltxnd, G., and Olianas, M. C., 1981, Role of GABA in the striatal output system globus pallidus, nucleus entopeduncularis, substantia nigra and nucleus subthalamicusin: “GABA and the Basal Ganglia.” Advances in Biochem. Psychopharmacol, Vol. 30, G. DiChiara, and G. L. Gessa, eds.. Raven Press, New York.
Schultz, W., 1982, Depletion of dopamine in the striatum as an experimental model of Parkinsonism: direct effects and adaptive mechanismsProgr. Neurobiol., 18: 121.
Schwab, R. S., Chafetz, M. E., and Walker, S., 1954, Control of two simultaneous voluntary acts in normal and in parkinsonism.Arch. Neurol. Psychiatry, 72:591.
Schwarz, M., Sontag, K.-H. and Wand, P., 1984, Sensory-motorprocessing in substantia nigra pars reticulata in conscious cats, JPhysiol. (Lond)., 347, (in press).
Stark, L., 1968, Neurological control systems — studies in bioengineering. Plenum, New York.
Wolfarth, S., Kolasiewicz, W., and Sontag, K.-H., 1981, The effects of muscimol and picrotoxin injections into the cat substantia nigra, Naunyn-SchiemedebergsArch. Pharmacol., 317.
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Sontag, KH., Heim, C., Schwarz, M., Jaspers, R., Cools, A.R., Wand, P. (1984). Consequences of Disturbed GABA-Ergic Transmission in Substantia Nigra Pars Reticulata in Freely Moving Cats on their Motor Behaviour, and in Anaesthetized Cats on their Spinal Motor Elements. In: McKenzie, J.S., Kemm, R.E., Wilcock, L.N. (eds) The Basal Ganglia. Advances in Behavioral Biology, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1212-3_25
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DOI: https://doi.org/10.1007/978-1-4684-1212-3_25
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