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Epilepsy

Pathophysiology of Cerebral Dysfunction

  • Chapter
Cerebral Energy Metabolism and Metabolic Encephalopathy

Abstract

Patients with epilepsy commonly suffer changes in mental functions. This can be caused by the seizure process itself, either focal or generalized, or related to the postictal state. Recurrent seizures, or status epilepticus, cause a profound change in mental function that often lasts several days following cessation of the motor convulsions. Side effects of anticonvulsant medicines and drug toxicity must also be considered in a differential diagnosis of encephalopathy in patients with epilepsy. Finally, a physician must often rule out other causes of mental change that are either a consequence of a seizure, such as head trauma, or are present as part of a pathophysiological disease process that includes seizures, such as the other causes of metabolic encephalopathy discussed in this book. These issues are summarized in Table I.

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References

  • Aminoff, M. J., and Simon, R. P., 1980, Status epilepticus—Causes, clinical features, and consequences in 98 patients, Am. J. Med. 69: 657–666.

    Article  PubMed  CAS  Google Scholar 

  • Bakay, R. A. E., and Harris, A. B., 1981, Neurotransmitter, receptor and biochemical changes in monkey cortical epileptic foci, Brain Res. 206: 387–404.

    CAS  Google Scholar 

  • Bancaud, J., Talairach, J., Morel, P., Bresson, M., Bonis, A., Geier, S., Hemon, H., and Buser, P., 1974, Generalized epileptic seizures elicited by electrical stimulation of the frontal lobe in man, Electroencephalogr. Clin. Neurophysiol. 37: 275–282.

    CAS  Google Scholar 

  • Basan, N. G., Jr., 1970, Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain, Biochem. Biophys. Acta 218: 1–10.

    Google Scholar 

  • Bayne, L. L., and Simon, R. P., 1981, Systemic and pulmonary vascular pressure during generalized seizures in sheep, Neurology 10: 566–569.

    CAS  Google Scholar 

  • Ben-Ari, Y., Tremblay, E., Ottersen, O. P., and Meldrum, B. S., 1980, The role of epileptic activity in hippocampal and “remote” cerebral lesions induced by kainic acid, Brain Res. 191: 79–97.

    CAS  Google Scholar 

  • Blennow, G., Nilsson, B., and Siesjo, B. K., 1977, Sustained epileptic seizures complicated by hypoxia, arterial hypotension or hyperthermia: Effects on cerebral energy state, Acta Physiol. Scand. 100: 126–128.

    Article  CAS  Google Scholar 

  • Brierly, J. B., 1976, Cerebral hypoxia, in: Greenfield’s Neuropathology ( W. Blackwood and J. A. N. Corsellis, eds.), Edward Arnold, London, pp. 43–85.

    Google Scholar 

  • Brooks, B. R., and Adams, R. D., 1975, Cerebrospinal fluid acid-base and lactate changes after seizures in unanesthetized man. I. Idiopathic seizures, Neurology 25: 935–942.

    PubMed  CAS  Google Scholar 

  • Butler, A. B., Willmore, L. J., Fuller, P. M., and Blass, N. H., 1976, Focal alteration of dendrites and astrocytes in rat cerebral cortex during initiation of cobalt-induced epileptiform activity, Exp. Neurol. 51: 216–228.

    CAS  Google Scholar 

  • Caspars, H., and Speckmann, E. J., 1972, Cerebral pO2 and pCO2 and pH: Changes during convulsive activity and their significance for the spontaneous arrest of seizures, Epilepsia 13: 699–729.

    Article  Google Scholar 

  • Celesia, G. G., 1976, Modern concepts of status epilepticus, J. Am. Med. Assoc. 235: 1571–1574.

    Article  CAS  Google Scholar 

  • Chan, P. H., Fishman, R. A., Lee, J. L., and Candelise, L., 1979, Effects of excitatory neurotransmitter amino acids on swelling of rat brain cortical slices, J. Neurochem. 33: 1309–1315.

    Article  PubMed  CAS  Google Scholar 

  • Chapman, A. G., Meldrum, B. S., and Siesjo, B. K., 1977, Cerebral metabolic changes during prolonged epileptic seizures in rats, J. Neurochem. 28: 1025–1035.

    Article  CAS  Google Scholar 

  • Chapman, A. G., Ingvar, M., and Siesjo, B. K., 1980, Free fatty acids in the brain in bicucullineinduced status epilepticus, Acta Physiol. Scand. 110: 335–336.

    Article  CAS  Google Scholar 

  • Collins, R. C., 1976, Metabolic response to focal penicillin seizures in rat: Spike discharge vs. afterdischarge, J. Neurochem. 27: 1473–1482.

    Article  CAS  Google Scholar 

  • Collins, R. C., 1978a, Use of cortical circuits during focal penicillin seizures: An autoradiographic study with [“C]deoxyglucose, Brain Res. 150: 487–501.

    CAS  Google Scholar 

  • Collins, R. C., 1978b, Kindling of neuroanatomic pathways during recurrent focal penicillin seizures, Brain Res. 150: 503–517.

    CAS  Google Scholar 

  • Collins, R. C., and Caston, T. V., 1979a, Activation of cortical circuits during interictal spikes, Ann. Neurol. 6: 117–125.

    CAS  Google Scholar 

  • Collins, R. C., and Caston, T. V., 1979b, Functional anatomy of occipital lobe seizures: An experimental study in rats, Neurology 29: 705–716.

    PubMed  CAS  Google Scholar 

  • Collins, R. C., and Mehta, S., 1978, Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures, Brain Res. 157: 311–320.

    CAS  Google Scholar 

  • Collins, R. C., and Nandi, N., 1982. Focal seizures disrupt the incorporation of amino acid into protein: An autoradiographic study using 1–14-C-leucine, Brain Res. 248: 102–120.

    Article  Google Scholar 

  • Collins, R. C., and Olney, J. W., 1982, Focal cortical seizures cause distant thalamic lesions, Science 218: 177–179.

    Article  PubMed  CAS  Google Scholar 

  • Collins, R. C., Posner, J. B., and Plum, F., 1970, Cerebral energy metabolism during electroshock seizures in mice, Am. J. Physiol. 218: 943–950.

    PubMed  CAS  Google Scholar 

  • Collins, R. C., Kennedy, C., Sokoloff, L., and Plum, F., 1976, Metabolic anatomy of focal motor seizures, Arch. Neurol. 33: 536–542.

    CAS  Google Scholar 

  • Collins, R. C., Conklin, W., Der, T., and Caston, T. V., 1981, Focal cortical seizures disrupt sub- cortical blood flow and metabolism, J. Cereb. Blood Flow Metab. 1 (suppl. 1): 596–597.

    Google Scholar 

  • Collins, R. C., Lothman, E. W., and Olney, J., 1983a, Status epilepticus in the limbic system—Biochemical and pathological changes, in: Status Epilepticus: Mechanisms of Brain Damage and Treatment, Volume 34, Advances in Neurology ( A. D. Delgado-Escueta, C. G. Wasterlain, D. M. Trieman, and R. J. Porter, eds.), Raven Press, New York.

    Google Scholar 

  • Collins, R. C., Olney, J. W., and Lothman, E. W., 1983b, Metabolic and pathological consequences of focal seizures, in: Epilepsy ( A. A. Ward, Jr., J. K. Penry, and D. Purpura, eds.), Raven Press, New York, pp. 87–107.

    Google Scholar 

  • Corsellis, J. A. N., and Bruton, C. J., 1983, Neuropathology of status epilepticus in humans, in: Status Epilepticus: Mechanisms of Brain Damage and Treatment, Volume 34, Advances in Neurology, ( A. D. Delgado-Escueta, C. G. Wasterlain, D. M. Trieman, and R. J. Porter, eds.), Raven Press, New York, pp. 129–139.

    Google Scholar 

  • Cotman, C. W., Banker, G., Zornetzer, S. F., and McGaugh, J. L., 1971, Electroshock effects on brain protein synthesis: Relation to brain seizures and retrograde amnesia, Science 173: 454–456.

    Article  PubMed  CAS  Google Scholar 

  • Crowell, R. M., 1970, Distant effects of a focal epileptogenic process, Brain Res. 18: 137–154.

    Article  PubMed  CAS  Google Scholar 

  • Darnell, J. C., and Jay, S. J., 1982, Recurrent post-ictal pulmonary edema: A case report and review of the literature, Epilepsia 23: 71–83.

    Article  PubMed  CAS  Google Scholar 

  • Delgado-Escueta, A. V., and Bajorek, J. G., 1982, Status epilepticus: Mechanisms of brain damage and rational management, Epilepsia 23 (suppl. 1): 529–541.

    Article  Google Scholar 

  • Delgado-Escueta, A. V., and Horan, M. P., 1980, Brain synaptosomes in epilepsy: Organization of ionic channels and the Na +-K± pump, in: Antiepileptic Drugs: Mechanisms of Action ( G. Glaser, D. K. Penry, and D. J. Woodbury, eds.), Raven Press, New York, pp. 85–126.

    Google Scholar 

  • Delgado-Escueta, A. V., Boxley, J., Stubbs, N., Waddell, G., and Wilson, W. A., 1974, Prolonged twilight state and automatisms: A case report, Neurology 24: 331–339.

    Google Scholar 

  • Delgado-Escueta, A. V., Bacsal, F. E., and Treiman, D. M., 1982, Complex partial seizures in closecircuit television and EEG: A study of 691 attacks in 79 patients, Ann. Neurol. 11: 292–300.

    Article  Google Scholar 

  • DePasquet, E. G., Gaudin, E. S., Bianchi, A., and DeMendilaharsu, S. A., 1976, Prolonged and monosymptomatic dysphasic status epilepticus, Neurology 26: 244–247.

    CAS  Google Scholar 

  • Dietzel, I., Heinemann, U., Hofmeier, G., and Lux, H. D., 1980, Changes in the extracellular volume in the cerebral cortex of cats in relation to stimulus induced epileptiform afterdischarges, in: Physiology and Pharmacology of Epileptogenic Phenomena ( M. R. Klee, H. Dieterlux, and E.-J. Speckman, eds.), Raven Press, New York, pp. 5–12.

    Google Scholar 

  • Dikman, S., and Matthews, C. G., 1977, Effect of major motor seizure frequency upon cognitive — intellectual functions in adults, Epilepsia 18:21–36.

    Google Scholar 

  • Dinner, D. S., Lueders, H., Lederman, R., and Gretter, T. E., 1981, Aphasic status epilepticus: A case report, Neurology 31: 888–890.

    PubMed  CAS  Google Scholar 

  • Duffy, T. E., Howse, D. C., and Plum, F., 1975, Cerebral energy metabolism during experimental status epilepticus, J. Neurochem. 24: 925–934.

    Article  PubMed  CAS  Google Scholar 

  • Dymond, A. M., and Crandall, P. H., 1976, Oxygen availability and blood flow in the temporal lobes during spontaneous epileptic seizures in man, Brain Res. 102: 191–196.

    Article  PubMed  CAS  Google Scholar 

  • Elger, C. E., Speckman, E.-S., Caspers, H., and Prohaska, O., 1982, Focal interictal epileptiform discharges in the cortex of the rat: Laminar restriction and its consequences for activity descending to the cord, in: Physiology and Pharmacology of Epileptiform Phenomena ( M. R. Klee, H. Dicter Lux, E.-J. Speckman, eds.), Raven Press, New York, pp. 13–21.

    Google Scholar 

  • Ellis, J. M., and Lee, S. I., 1978, Acute prolonged confusion in later life as an ictal state, Epilepsia 19: 119–128.

    Article  PubMed  CAS  Google Scholar 

  • Engel, J., Jr., Ludwig, B. I., and Fetell, M., 1978, Prolonged partial complex status epilepticus: EEG and behavioral observations, Neurology 28: 863–869.

    PubMed  Google Scholar 

  • Engel, J., Jr., Kuhl, D. E., and Phelps, M. E., 1982, Patterns of human local cerebral glucose metabolism during epileptic seizures, Science 218: 64–66.

    Article  PubMed  Google Scholar 

  • Ferrendelli, J. A., and McDougal, D. B., Jr., 1971, The effect of electroshock on regional CNS energy reserves in mice, J. Neurochem. 18: 1197–1205.

    Article  PubMed  CAS  Google Scholar 

  • Fifkova, E., Anderson, C. L., Young, S. J., and Van Harreveld, A., 1982, Effect of anisomycin on stimulation-induced changes in dendritic spines of the dentate granule cells, J. Neurocytol. 11: 183–210.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, J., and Langmeier, M., 1980, Changes in the number, size and shape of synaptic vesicles in an experimental, projected cortical epileptic focus in the rat, Epilepsia 21: 571–585.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, S. P., Lee, J., Zetuchne, J., and Greenberg, J., 1977, Disseminated intervascular coagulation in status epilepticus, Thromb. Haemostasis 38: 909–914.

    CAS  Google Scholar 

  • Folbergrova, J., Ingvar, M., and Siesjo, B. K., 1981, Metabolic changes in cerebral cortex, hippo-campus, and cerebellum during sustained bicuculline-induced seizures, J. Neurochem. 37: 1228–1238.

    Article  CAS  Google Scholar 

  • Gilbert, G. J., 1978, Transient global amnesia: Manifestations of medial temporal lobe epilepsy, Clin. EEG 9: 147–152.

    Google Scholar 

  • Gloor, P., Olivier, A., Quesney, L. F., Andermann, F., and Horowitz, S., 1982, The role of the limbic system in experiential phenomena of the temporal lobe epilepsy, Ann. Neurol. 12: 129–144.

    CAS  Google Scholar 

  • Goldring, S., 1972, The role of prefrontal cortex in grand mal convulsion, Arch. Neurol. 2: 109–120.

    Google Scholar 

  • Greenwood, R. S., Takato, M., and Goldring, S., 1981, Potassium activity and changes in glial and neuronal membrane potentials during initiation and spread of afterdischarge in cerebral cortex of cat, Brain Res. 218: 279–298.

    CAS  Google Scholar 

  • Griffiths, T., Evans, M. C., and Meldrum, B. S., 1982, Intracellular sites of early calcium accu- mulation in the rat hippocampus during status epilepticus, Neurosci. Lett. 30: 329–334.

    CAS  Google Scholar 

  • Gutnick, M. J., and Prince, D. A., 1974, Effects of projected cortical epileptiform discharges on neuronal activities in cat VPL. I. Interictal discharge, J. Neurophysiol. 37: 1310–1327.

    PubMed  CAS  Google Scholar 

  • Gutnick, M. J., Heinemann, U., and Lux, H. D., 1979, Stimulus induced and seizure related changes in extracellular potassium concentration in cat thalamus (VPL), Electroencephalogr. Clin. Neurophysiol. 47: 329–344.

    CAS  Google Scholar 

  • Heinemann, U., and Pumain, R., 1980, Extracellular calcium activity changes in cat sensorimotor cortex induced by iontophoretic application of amino acids, Exp. Brain Res. 40: 247–250.

    Article  PubMed  CAS  Google Scholar 

  • Heinemann, U., Lux, H. D., and Gutnick, M. J., 1977, Extracellular free calcium and potassium during paroxysmal activity in the cerebral cortex of the cat, Exp. Brain Res. 27: 237–243.

    Article  PubMed  CAS  Google Scholar 

  • Holmes, G., 1927, Local epilepsy, Lancet 1: 957–962.

    Article  Google Scholar 

  • Horton, R. W., Meldrum, B. S., Pedley, T. A., and Siesjo, B. K., 1980, Regional cerebral blood flow in the rat during prolonged seizure activity, Brain Res. 192: 399–412.

    CAS  Google Scholar 

  • Houser, C. R., Vaughn, J. E., Barber, R. P., and Roberts, E., 1980, GABA neurons are the major cell type of the nucleus reticularis thalami, Brain Res. 200: 341–354.

    CAS  Google Scholar 

  • Howse, D. C. N., 1979, Metabolic responses to status epilepticus in the rat, cat and mouse, Can. J. Physiol. Pharmacol. 57: 205–212.

    Article  PubMed  CAS  Google Scholar 

  • Jackson, H., 1870, A study of convulsions, in: Selected Writings of John Hughlings Jackson, Volume 1 ( J. Taylor, ed.), Basic Books, New York, 1958, pp. 8–36.

    Google Scholar 

  • Jobsis, F. F., O’Connor, M., Vitale, A., and Vreman, H., 1971, Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity, J. Neurophysiol. 34: 735749.

    Google Scholar 

  • Jones, E. G., 1977, Some aspects of the organization of the thalamic reticular complex, J. Comp. Neurol. 162: 285–308.

    Google Scholar 

  • Jones, E. G., 1981a, Anatomy of cerebral cortex: Columnar input-output organization in: The Organization of the Cerebral Cortex (F. O. Schmitt, F. G. Worden, G. Adelman, and S. G. Dennis, eds.), MIT Press, Cambridge, pp. 199–236.

    Google Scholar 

  • Jones, E. G., 1981b, Functional subdivision and synaptic organization of the mammalian thalamus, Int. Rev. Physiol. 25: 173–245.

    CAS  Google Scholar 

  • Kato, M., Malamut, B. L., Caveness, W. F., Hosokawa, S., Wakisaka, S., and O’Neill, R., 1980, Local cerebral glucose utilization in newborn and pubescent monkeys during focal motor seizures, Ann. Neurol. 7: 204–212.

    CAS  Google Scholar 

  • Kennedy, C., DesRosiers, M. H., Jehle, M. H., Reivich, J. W., Sharp, F., and Sokoloff, L., 1975, Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with [14C]deoxyglucose, Science 187: 850–853.

    Article  PubMed  CAS  Google Scholar 

  • Knopman, D., Margolis, G., and Reeves, A. G., 1977, Prolonged focal epilepsy and hypoxemia as a cause of focal brain damage: A case study, Ann. Neurol. 1: 195–198.

    CAS  Google Scholar 

  • Kriesman, N. R., Lamanna, J. C., Rosenthal, M., and Sick, T. J., 1981, Oxidative metabolic responses with recurrent seizures in rat cerebral cortex: Role of systemic factors, Brain Res. 218: 175–188.

    Google Scholar 

  • Kriesman, N. R., Rosenthal, M., and LaManna, J. C., 1983, Cerebral oxygenation during recurrent seizures, in: Status Epilepticus: Mechanisms of Brain Damage and Treatment, Volume 34, Advances in Neurology ( A. Delgado-Escueta, C. G. Wasterlain, D. M. Treiman, and R. J. Porter, eds.), Raven Press, New York, pp. 231–240.

    Google Scholar 

  • Kugoh, T., and Hosokawa, K., 1977, Mental dullness associated with left frontal continuous focal discharge Folia Psychiatr. Neurol. Jpn. 31: 473–480.

    CAS  Google Scholar 

  • Kuhl, D. E., Engel, J., Jr., Phelps, M. E., and Selin, C., 1980, Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of’BFDG and “NH3, Ann. Neurol. 8: 348–360.

    CAS  Google Scholar 

  • Kunzle, H., 1975, Bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia. An autoradiographic study in macaca fascicularis, Brain Res. 88: 195209.

    Google Scholar 

  • Landau, W. M., and Kleffner, F. R., 1957, Syndrome of acquired aphasia with convulsive disorder in children, Neurology 7: 523–528.

    PubMed  CAS  Google Scholar 

  • Lawall, J., 1976, Psychiatric presentations of seizure disorders, Am. J. Psychiatry 133: 321–323.

    PubMed  CAS  Google Scholar 

  • Levine, D. N., and Finklestein, S., 1982, Delayed psychosis after right temporo-parietal stroke or trauma: Relation to epilepsy, Neurology 32: 267–273.

    PubMed  CAS  Google Scholar 

  • Lieb, J. P., Walsh, G. O., Babb, T. L., Walter, R. D., and Crandall, P. H., 1976, A comparison of EEG seizure patterns recorded with surface and depth electrodes in patients with temporal lobe epilepsy, Epilepsia 17: 137–160.

    Article  PubMed  CAS  Google Scholar 

  • Lothman, E. W., and Collins, R. C., 1981, Kainic acid induced limbic seizures: Metabolic, behavioral electroencephalographic, and neuropathological correlates, Brain Res. 218: 299–318.

    Article  PubMed  CAS  Google Scholar 

  • Lothman, E. W., and Somjen, G. G., 1975, Extracellular potassium activity, intracellular and extracellular responses in the spinal cord, J. Physiol. 252: 115–136.

    CAS  Google Scholar 

  • Lothman, E. W., LaManna, J., Cordingley, G., Rosenthal, M., and Somjen, G., 1975, Responses of electrical potential, potassium levels, and oxidative metabolic activity of the cerebral neocortex of cats, Brain Res. 88: 15–36.

    CAS  Google Scholar 

  • Markand, O. N., Wheeler, G. L., and Pollack, S. L., 1978, Complex partial status epilepticus (psychomotor status), Neurology 28: 189–196.

    PubMed  CAS  Google Scholar 

  • Matthews, C. G., and Harley, P., 1975, Cognitive and motor-sensory performance in toxic and nontoxic epileptic subjects, Neurology 25: 184–188.

    PubMed  CAS  Google Scholar 

  • Meldrum, B. S., 1983, Metabolic factors during prolonged seizures and their relation to nerve cell death, in: Status Epilepticus—Mechanisms of Brain Damage and Treatment, Volume 34, Advances in Neurology ( A. Delgado-Escueta, C. G. Wasterlain, D. M. Treema, and R. J. Porter, eds.). Raven Press, New York, pp. 261–276.

    Google Scholar 

  • Meldrum, B. S., and Brierly, J. B., 1973, Prolonged epileptic seizures in primates—Ischemic cell change and its relation to ictal physiological events, Arch. Neurol. 28: 10–17.

    CAS  Google Scholar 

  • Meldrum, B. S., and Horton, R. W., 1973, Physiology of status epilepticus in primates, Arch. Neurol. 28: 1–9.

    CAS  Google Scholar 

  • Meldrum, B. S., Vogoroux, R. A., and Brierly, J. B., 1973, Systemic factors and epileptic brain damage: Prolonged seizures in paralyzed artificially ventilated baboons, Arch. Neurol. 29: 82–87.

    CAS  Google Scholar 

  • Mersky, A. F., Primac, D. W., and Ajomone-Marsan, C., 1960, A comparison of the psychological test performance of patients with focal and non-focal epilepsy, Exp. Neurol. 2: 75–89.

    Google Scholar 

  • Mutani, R., Durelli, L., Mazzarino, M., Valentine, C., Monaco, F., Fumero, S., and Mondurao, A., 1977, Longitudinal changes of brain amino acid content occurring before, during and after epileptic activity, Brain Res. 122: 513–521.

    CAS  Google Scholar 

  • Nitsch, C., and Rinne, U., 1981, Large dense-core vessicle execytosis and membrane recycling in the mossy fiber synapses of the rabbit hippocampus during epileptiform seizures, J. Neurocytol. 10: 221–232.

    Article  Google Scholar 

  • Noebels, J. L., and Prince, D. A., 1978a, Development of focal seizures in cerebral cortex: Role of axon terminal bursting, J. Neurophysiol. 41: 1267–1281.

    PubMed  CAS  Google Scholar 

  • Noebels, J. L., and Prince, D. A., 1978b, Excitability changes in thalamocortical relay neurons during synchronous discharges in cat neocortex, J. Neurophysiol. 41: 1282–1296.

    PubMed  CAS  Google Scholar 

  • Okada, K., Ayala, G. F., and Sung, J. H., 1971, Ultrastructure of penicillin-induced epileptogenic lesions of the cerebral cortex in cats, J. Neuropathol. Exp. Neurol. 30: 337–353.

    Article  PubMed  CAS  Google Scholar 

  • Olney, J. W., 1978, Neurotoxicity of excitatory amino acids, in: Kainic Acid as a Tool in Neurobiology ( E. McGeer, J. W. Olney, and P. L. McGeer, eds.), Raven Press, New York, pp. 110–126.

    Google Scholar 

  • Passonneau, J. V., 1969, Energy metabolites in experimental seizures, in: Basic Mechanisms of the Epilepsies ( H. H. Jasper, A. A. Ward, and A. Pope, eds.), Little, Brown and Co., New York, pp. 98–103.

    Google Scholar 

  • Penfield, W., 1937, The circulation of the epileptic brain. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 18: 605–637.

    Google Scholar 

  • Penfield, W., and Milner, B., 1958, Memory deficit produced by bilateral lesions in the hippocampal zone, Arch. Neurol. Psychiatry 70: 475–497.

    Google Scholar 

  • Perry, T. L., and Hansen, S., 1981, Amino acid abnormalities in epileptogenic foci, Neurology 31: 872–876.

    PubMed  CAS  Google Scholar 

  • Plum, F., Howse, D. C., and Duffy, T. E., 1974, Metabolic effects of seizures, in: Brain Dysfunction in Metabolic Disorders (F. Plum, ed.), Res. Publ. Assoc. Res. Nerv. Ment. Dis. 53:141–157, Raven Press, New York.

    Google Scholar 

  • Prince, D. A., and Wilder, B. J., 1967, Control mechanisms in cortical epileptogenic foci—“surround inhibition,” Arch. Neurol. 16: 194–202.

    Article  PubMed  CAS  Google Scholar 

  • Prince, D. A., Lux, H. D., and Neher, F., 1973, Measurement of extracellular potassium activity in cat cortex, Brain Res. 50: 489–495.

    Article  PubMed  CAS  Google Scholar 

  • Rausch, R., Lieb, J. B., and Crandall, P. H., 1978, Neuropsychological correlates of depth spike activity in epileptic patients, Arch. Neurol. 35: 699–705.

    Article  PubMed  CAS  Google Scholar 

  • Ribak, C. E., and Riffenstein, R. J., 1982, Selective inhibitory synapse loss in chronic cortical slabs: A morphological basis for epileptic susceptibility, J. Can. Physiol. Pharmacol. 60: 864–870.

    Article  CAS  Google Scholar 

  • Ribak, C. E., Harris, A. B., Vaughn, J. E., and Robert, E., 1979, Inhibitory, GABAergic nerve terminals decrease at sites of focal epilepsy, Science 205: 211–240.

    Article  PubMed  CAS  Google Scholar 

  • Rowan, A. J., and Scott, D. F., 1970, Major status epilepticus. Acta. Neurol. Scand. 46: 573–584.

    Article  PubMed  CAS  Google Scholar 

  • Sakai, F., Meyer, J. F., Naritomi, H., and Hsu, M-C., 1978, Regional cerebral blood flow and EEG in patients with epilepsy, Arch. Neurol. 35: 648–657.

    Article  PubMed  CAS  Google Scholar 

  • Scheibel, M. E., Crandall, P. H., and Scheibe!, A. B., 1974, The hippocampal-dentate complex in temporal lobe epilepsy, Epilepsia 15: 55–80.

    Article  PubMed  CAS  Google Scholar 

  • Schwartzkroin, P. A., vanDuijn, H., and Prince, D. A., 1974, Effects of projected cortical epileptiform discharges on unit activity in the cat cuneate nucleus, Exp. Neurol. 43: 106–123.

    Article  PubMed  CAS  Google Scholar 

  • Schwartzkroin, P. A., Mutani, R., and Prince, D. A., 1975, Orthodromic and antidromic effects of a cortical epileptiform focus on ventrolateral nucleus of the cat, J. Neurophysiol. 38: 795–811.

    CAS  Google Scholar 

  • Scoville, W. B., and Milner, B., 1957, Loss of recent memory after bilateral hippocampal lesions, J. Neurol. Neurosurg. Psychiatry 20: 11–21.

    CAS  Google Scholar 

  • Shank, R. P., and Aprison, M. H., 1979, Biochemical aspects of the neurotransmitter function of glutamate, in: Glutamic Acid: Advances in Biochemistry and Physiology (L. J. Fuller, S. Garattine, M. R., Kare, W. A. Reynolds, and R. J. Wurtman, eds.), Raven Press, New York, pp. 139–150.

    Google Scholar 

  • Shoumaker, R. D., Bennett, D. R., Bray, P. F., and Curless, R. G., 1974, Clinical and EEG manifestations of an unusual aphasic syndrome in children, Neurology 24: 10–16.

    PubMed  CAS  Google Scholar 

  • Siesjo, B. K., 1978, Brain Energy Metabolism, John Wiley and Sons, New York.

    Google Scholar 

  • Simpson, H., Habel, A. H., and George, E. L., 1977, Cerebrospinal fluid acid-base status and lactate and pyruvate concentrations after convulsions of varied duration and etiology in children, Arch. Dis. Child. 52: 844–849.

    Article  CAS  Google Scholar 

  • Singhal, P. C., Chugh, K. S., and Gulati, D. R., 1978, Myoglobinuria and renal failure after status epilepticus, Neurology 28: 200–201.

    PubMed  CAS  Google Scholar 

  • Sloviter, R. S., and Damiano, B. P., 1981, Sustained electrical stimulation of the perforant path duplicates kainate-induced electrophysiological effects and hippocampal damage in rats, Neurosci. Lett. 24: 279–284.

    Article  PubMed  CAS  Google Scholar 

  • Soderfeld, B., Kalimo, H., Olsson, Y., and Siesjo, B. K., 1981, Pathogenesis of brain lesions caused by experimental epilepsy, Acta. Neuropathol. 54: 219–231.

    Article  Google Scholar 

  • Sokoloff, L., Reivich, M., Kennedy, C., DesRosiers, M. H., Pettigrew, K. D., Sakurada, O., and Shinohara, M., 1977, The [14-C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedures and norma values in the conscious and anesthetized albino rat, J. Neurochern. 28: 897–916.

    Article  CAS  Google Scholar 

  • Tenny, R. T., Sharbrough, F. W., Anderson, R. E., and Sundt, T. M, 1978, Correlation of intracellular redox states and pH with blood flow in primary and secondary seizure foci, Ann. Neurol. 8: 564–573.

    Article  Google Scholar 

  • Traub, R. D., and Llinas, R., 1979, Hippocampal pyramidal cells: Significance of dendritic ion conductances for neuronal function and epileptogenesis, J. Neurophysiol. 42: 476–496.

    CAS  Google Scholar 

  • Ueno, H., Yamashita, Y., and Caveness, W. F., 1975, Regional cerebral blood flow pattern in focal epileptiform seizures in the monkey, Exp. Neurol. 47: 81–96.

    CAS  Google Scholar 

  • VanGelder, N. M., Sherwin, A. L., and Rasmussen, T., 1972, Amino acid content of epileptogenic human brain: Focal versus surround region, Brain Res. 40: 385–393.

    CAS  Google Scholar 

  • Van Harreveld, A., and Fifkova, E., 1975, Swelling of dendritic spines in the fascia dentata after stimulation of the perforant fibers as a mechanism of post-tetanic potentiation, Exp. Neurol. 49: 736–749.

    Google Scholar 

  • Walker, A. E., 1959, The state of consciousness in focal motor convulsions, Epilepsia 1: 592–599.

    Article  Google Scholar 

  • Walker, A. E., Poggio. G. F., and Andy, O. J., 1956, Structural spread of cortically induced epileptic discharges, Neurology 6: 616–626.

    Google Scholar 

  • Walshe, F. M. R., 1943, On the mode of representation of movements in the motor cortex with special reference to “convulsions beginning unilaterally” (Jackson), Brain 66: 104–139.

    Article  Google Scholar 

  • Warren, D. J., Leitch, A. G., and Leggett, A. J. E., 1975, Hyperuricaemic acute renal failure after epileptic seizures, Lancet 2: 385–387.

    Article  PubMed  CAS  Google Scholar 

  • Wasterlain, C. G., 1974, Inhibition of cerebral protein synthesis by epileptic seizures without motor manifestations, Neurology 24: 175–180.

    PubMed  CAS  Google Scholar 

  • Wasterlain, C. G., and Duffy, T. E., 1976, Status epilepticus in immature rats—Protective effects of glucose on survival and brain development, Arch. Neurol. 33: 821–827.

    Article  PubMed  CAS  Google Scholar 

  • Wells, C. E., 1975, Transient ictal psychosis, Arch. Gen. Psychiatry 32: 1201–1203.

    CAS  Google Scholar 

  • Whittam, R., 1962, The dependence of the respiration of brain cortex on active cation transport, Biochem. J. 82: 205–212.

    PubMed  CAS  Google Scholar 

  • Wieser, H. G., 1980, Temporal lobe or psychomotor status epilepticus. A case report, Electroencephalogr. Clin. Neurophysiol. 48: 558–572.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Washington University Medical School, St. Louis, Missouri, 63110, USA

    Robert C. Collins

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  1. Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, 77025, Houston, Texas, USA

    David W. McCandless

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© 1985 Plenum Press, New York

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Collins, R.C. (1985). Epilepsy. In: McCandless, D.W. (eds) Cerebral Energy Metabolism and Metabolic Encephalopathy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1209-3_12

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  • DOI: https://doi.org/10.1007/978-1-4684-1209-3_12

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