Molecular Heterogeneity in Peripheral Glia
Immunohistochemical studies have transformed our picture of the chemical complexity of both the CNS and PNS. The chemical specificity of antibodies combined with the visual resolution obtained by microscopic examination of tissue sections or cell cultures has allowed chemical analysis of the component parts of the nervous system at a cellular level, and provides a means of detecting molecular heterogeneity in both morphologically similar and different types of cells. This is well illustrated in the case of neuropeptides. The use of antibodies recognizing 30–40 different peptides or peptide fragments in immunohistochemical studies has revealed complex and often partly overlapping patterns of distribution in central and peripheral neurons, which generally cut across, rather than coincide with, traditional population categories based on morphology or transmitter type (e.g. Schultzberg et al., 1980).
KeywordsSciatic Nerve Schwann Cell Satellite Cell Glutamine Synthetase Myenteric Plexus
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