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Ganglioside Structure, Function, and Biomedical Potential pp 169–181Cite as

Cellular Localization of Gangliosides in the Mouse Cerebellum: Analysis Using Neurological Mutants

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 174))

Abstract

Understanding the function of gangliosides in the central nervous system (CNS) requires knowledge of their cellular distribution. It would be important to know if certain gangliosides are more or less concentrated in specific neural cell types and to know how gangliosides are distributed over the surface of neurons. In other words, are all gangliosides randomly distributed over the entire cell surface or are there domains on the neuronal surface (synapse, dendrite, perikaryon, axon hillock, axon) where the concentration of one ganglioside predominates over that of another. The distribution of gangliosides between cells and within cells may also vary with age. Hence, a series of neurological mouse mutants that lose specific populations of cerebellar neurons at various stages of development provides an excellent system for studying the cellular distribution of gangliosides in the CNS.

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Authors and Affiliations

  1. Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA

    Thomas N. Seyfried & Robert K. Yu

Authors
  1. Thomas N. Seyfried
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  2. Robert K. Yu
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Editors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Robert W. Ledeen  & Kunihiko Suzuki  & 

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Robert K. Yu

  3. New York State Psychiatric Institute, New York, New York, USA

    Maurice M. Rapport

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© 1984 Plenum Press, New York

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Seyfried, T.N., Yu, R.K. (1984). Cellular Localization of Gangliosides in the Mouse Cerebellum: Analysis Using Neurological Mutants. In: Ledeen, R.W., Yu, R.K., Rapport, M.M., Suzuki, K. (eds) Ganglioside Structure, Function, and Biomedical Potential. Advances in Experimental Medicine and Biology, vol 174. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1200-0_15

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  • DOI: https://doi.org/10.1007/978-1-4684-1200-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1202-4

  • Online ISBN: 978-1-4684-1200-0

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