Neurofilament Transport in Axonal Regeneration

Implications for the Control of Axonal Caliber
  • Paul N. Hoffman
  • John W. Griffin
  • Donald L. Price
Part of the Advances in Neurochemistry book series (volume 22)

Abstract

Regenerating axons have been intensively studied with regard to the mechanisms and determinants of elongation, and several lines of evidence suggest that the delivery of cytoskeletal proteins (tubulin and actin, in particular) are correlates of outgrowth and may be rate limiting (see Lasek and Hoffman, 1976; Wujck and Lasek. 1983). In addition lo changes in axonal length, regeneration involves marked changes in axonal caliber and in cytoskeletal composition. The rcgcneraling axon provides the best available system in which to test critically the hypotheses underlying several of our recent studies. These hypotheses are that neurofilament content is the major correlate of axonal caliber and that axonal neurofilament content is, in turn, determined, in large part, by neurofilament delivery via slow axonal transport. This review will first summarize the general problem of the determinants of axonal caliber and then focus on recent data from regenerating nerves. These data can be considered in terms of three regions of the regenerating axon—the proximal stump, the maturing sprouts, and the distal sprouts.

Keywords

Migration Hexanedione Polypeptide Neurol Tral 

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Paul N. Hoffman
    • 1
  • John W. Griffin
    • 2
  • Donald L. Price
    • 3
  1. 1.Department of OphthalmologyThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Departments of Neurology and NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Departments of Pathology, Neurology, and NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA

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