Diffusional Coupling in a Hemoglobin-Free Perfused Capillary-Tissue Structure
The theoretical prediction of substrate levels in tissue from a mathematical model has been an intensely investigated topic since Krogh initiated the concept in the period 1918 to 1929 (Krogh, 1919). Oxygen has been the most widely investigated substrate because of its obvious necessity for cell viability. However, attempts to study this viability, both experimentally and by means of a mathematical model, have been frustrated by the presence of the blood hemoglobins. The hemoglobin has the effect of a nonlinear buffer which complicates the description by mathematical model and introduces experimental difficulties in measuring actual oxygen levels in perfused tissues. Schubert (1976) had attempted to circumvent these difficulties by using an oxygen saturated modified Krebs-Henseleit perfusate.
KeywordsDIFFUSIONAL Coupling Axial Diffusion Lower Pressure Range Substrate Distribution Capillary Entrance
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