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Deleterious Effects of Oxygen Radicals on Reoxygenated Myocardial Cells

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Oxygen Transport to Tissue-V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 169))

Abstract

Oxygen deprivation induces severe damage in cardiac muscle. The ultrastructural leions, which include mitochondrial and cellular swellings and structural defects in cell plasma membranes, are accentuated by the duration of the hypoxic period (Hearse et al., 1973).

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References

  • Aebi, H., 1974, in: “Methods of Enzymatic Analysis”, H.U. Bergmeyer, ed., Academic Press, New York.

    Google Scholar 

  • Antonini, E., Brunori, M., Greenwood, C., and Malmström, B.G., 1970, Catalytic mechanism of cytochrome oxidase, Nature, 228: 936.

    Article  PubMed  CAS  Google Scholar 

  • Boveris, A., 1977, in: “Oxygen and Physiological Funtion”, F.F. Jöbsis, ed., Professional Information Library, Washington.

    Google Scholar 

  • Chance, B., Sies, H., and Boveris, A., 1979, Hydroperoxide metabolism in mammalian organs, Physiol. Rev., 59: 527.

    PubMed  CAS  Google Scholar 

  • Czapski, G., and Ilan, Y.A., 1978, On the generation of the hydroxylation agent from superoxide radical. Can the Haber-Weiss reaction be the source of OH radicals?, Photochem. Photobiol., 28: 651.

    Article  CAS  Google Scholar 

  • Del Maestro, R.F., 1980, An approach to free radicals in medicine and biology, Acta Physiol. Scand., Suppl. 492: 153.

    Google Scholar 

  • Feuvray, D., and de Leiris, J., 1975, Ultrastructural modifications induced by reoxygenation in the anoxic isolated rat heart perfused without exogenous substrate, J. M. C. C, 7: 307.

    CAS  Google Scholar 

  • Fong, K.L., Mc Cay, P.B., Poyer, J.L., Leele, B.B., and Misra, H., 1973, Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity, J. Biol. Chenu, 248: 7792.

    CAS  Google Scholar 

  • Fridovich, I., 1975, Superoxide dismutases, Ann. Rev. Biochem., 44: 147.

    Article  PubMed  CAS  Google Scholar 

  • Fridovich, I., 1978, Superoxide radicals, superoxide dismutases and the aerobic life style, Photochem. Photobiol., 28: 733.

    Article  PubMed  CAS  Google Scholar 

  • Ganote, C.E., and Kaltenbach, J.P., 1979, Oxygen-induced enzyme release: early events and a proposed mechanism, J. Mol. Cell. Cardiol., 11: 389.

    Article  PubMed  CAS  Google Scholar 

  • Ganote, C.E., Seabra Gomes, R., Nayler, W.G., and Jennings, R.B., 1975, Irreversible myocardial injury in anoxic perfused rat hearts, Am. J. Pathol., 80: 419.

    PubMed  CAS  Google Scholar 

  • Gauduel, Y., Karagueuzian, H.S., and de Leiris, J., 1979, Deleterious effects of endogenous catecholamines ön hypoxic myocardial cells following reoxygenation, J. Mol. Cell. Cardiol., 11: 717.

    Article  PubMed  CAS  Google Scholar 

  • Gutmann, I., and Wahlefeld, A.W., 1974, in: “Methods of Enzymatic Analysis”, H.U. Bergmeyer, ed., Academic Press, New York.

    Google Scholar 

  • Halliwell, B., 1978, Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: the key role of superoxide dismutase, Cell Biol. Int. Rep., 2: 113.

    Article  PubMed  CAS  Google Scholar 

  • Haugaard, N., 1968, Cellular mechanisms of oxygen toxicity, Physiol. Rev., 48: 312.

    Google Scholar 

  • Hearse, D.J., 1978, The oxygen paradox and the calcium paradox: two facets of the same problem?, J. Mol. Cell. Cardiol., 10: 641.

    Article  PubMed  CAS  Google Scholar 

  • Hearse, D.J., Humphrey, S.M., and Chain, E.B., 1973, Abrupt reoxygenation of the anoxic potassium arrested perfused rat heart: a study of myocardial enzyme release, J. Mol. Cell. Cardiol., 5: 395.

    Article  PubMed  CAS  Google Scholar 

  • Hunter, F.E., Scott, J.A., Hoffsten, P.E., Gebicki, J.M., Weinstein, J., and Schneider, A., 1964, Studies on the mechanism of swelling lysis and disintegration of isolated liver mitochondria exposed to mixtures of oxidized and reduced glutathione, J. Biol. Chem., 239: 614.

    PubMed  CAS  Google Scholar 

  • Kosower, N.S., and Kosower, E.M., 1976, The glutathione-glutathione disulfide system, in: “Free Radicals in Biology”, W.A. Pryor, ed., Academic Press, London.

    Google Scholar 

  • Langendorff, O., 1895, Untersuchungen am überlebenden Säugetierher-zen, Pflügers Arch. Ges. Physiol., 61: 251.

    Google Scholar 

  • Loschen, G., Azzi, A., and Flohe, L., 1973, Mitochondrial H2O2 formation: relationship with energy conservation, FEBS Lett., 33: 89.

    Article  Google Scholar 

  • Narabayashi, H., Takeshige, K., and Minakami, S., 1982, Alteration of inner membrane components and damage to electron transfer activities of bovine heart submitochondrial particles induced by NADPH dependent lipid peroxidation, Biochem. J., 202: 97.

    PubMed  CAS  Google Scholar 

  • Nohl, H., and Hegner, D., 1978a, Evidence for the existence of catalase in the matrix space of rat heart mitochondria, FEBS Lett., 89: 126.

    Article  PubMed  CAS  Google Scholar 

  • Nohl, H., and Hegner, D., 1978b, Do mitochondria produce oxygen radicals “in vivo”?, Eur. J. Biochem., 82: 563.

    Article  PubMed  CAS  Google Scholar 

  • Nohl, H., and Jordan, W., 1980, The metabolic fate of mitochondrial hydrogen peroxide, Eur. J. Biochem., 111: 203.

    Article  PubMed  CAS  Google Scholar 

  • Pryor, W.A., 1966, “Free Radicals”, Mc Graw-Hill, New York.

    Google Scholar 

  • Pryor, W.A., 1976, in: “Free Radicals in Biology”, W.A. Pryor, ed., Academic Press, New York.

    Google Scholar 

  • Siegel, A.L., and Cohen, P.S., 1974, in: “Methods of Enzymatic Analysis”, H.U. Bergmeyer, ed., Academic Press, New York.

    Google Scholar 

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© 1984 Plenum Press, New York

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Gauduel, Y., Duvelleroy, M.A. (1984). Deleterious Effects of Oxygen Radicals on Reoxygenated Myocardial Cells. In: Lübbers, D.W., Acker, H., Leniger-Follert, E., Goldstrick, T.K. (eds) Oxygen Transport to Tissue-V. Advances in Experimental Medicine and Biology, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1188-1_37

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  • DOI: https://doi.org/10.1007/978-1-4684-1188-1_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1190-4

  • Online ISBN: 978-1-4684-1188-1

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