Abstract
Resent theoretical analysis (Purves, 1977; Fradisek, Kordas and Svetina, 1978) clearly showed that in the end-plate the receptor response is dependent on many parameters, e.g. duration of the pulse, receptor distribution, position of the microelectrode tip, kinetics of receptor-transmitter interactions and cooperativity. In order to compare these mathematical analysis with the experimental data, the current evoked by iontophoretically applied transmitter was studied.
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References
PURVES R.D., The time course of cellular responses to iontophoretically applied drugs, J. theor. Biol. 65, 327, 1977.
GRADISEK A., KORDAS M. and SVETINA S., A mathematical analysis of factors determining the time-course of membrane conductance change evoked by electrophoretic drug application, J. theor. Biol. 71, 311–322, 1978.
PEPER K., DREYER F. and MÜLLER K., Analysis of cooperativity of drug-receptor interaction by quantitative iontophoresis at frog motor end plate. Cold Spring Harbor Symp. Quant. Biol. 40, 187–192, 1975.
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© 1980 Plenum Press, New York
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Scuka, M. (1980). The Time Course of Membrane Conductance Change Evoked by Iontophoretically Applied Acetylcholine. In: Borsellino, A., Omodeo, P., Strom, R., Vecli, A., Wanke, E. (eds) Developments in Biophysical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1077-8_5
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DOI: https://doi.org/10.1007/978-1-4684-1077-8_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-1079-2
Online ISBN: 978-1-4684-1077-8
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