Abstract
Medical diagnosis is greatly aided by laboratory tests that indicate damage or malfunction in specific tissues. Since most tissues have direct access to the blood, changes in the physiological or pathological state of specific organs are often reflected by changes in blood composition or the appearance of specific tissue markers. For example, specific enzymes are elevated in the serum after damage to heart, liver, or muscle. Development of diagnostic tests for disorders of the nervous system, however, has been hindered by lack of specific neural markers. Moreover, the central nervous system (CNS) usually lacks direct exchange with blood because of the blood-brain barrier. The fluid compartment in direct contact with the CNS is the cerebrospinal fluid (CSF), and one might expect that pathological changes in the CNS would be reflected in the CSF.
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Cohen, S.R., Brooks, B.R., Jubelt, B., Herndon, R.M., McKhann, G.M. (1980). Myelin Basic Protein in Cerebrospinal Fluid. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1039-6_34
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DOI: https://doi.org/10.1007/978-1-4684-1039-6_34
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