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Neurobiology of Cerebrospinal Fluid 1 pp 337–344Cite as

Cerebrospinal Fluid Cyclic Nucleotide Alterations in Traumatic Coma

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Abstract

Cyclic AMP [(cAMP) cyclic adenosine 3′,5′-monophosphate] was initially discovered by Sutherland and Rall31 in 1958. Further investigations have led to the concept that cAMP may be involved as the intracellular mediator of the actions of other hormones and of various putative synaptic transmitters. According to this concept, first messengers, the hormones or transmitters themselves, move from their cells of origin and induce the synthesis of cAMP in their target cells. Thereby, cAMP, by activating an appropriate sequence of enzymes, can evoke the specific response of a target cell to the hormone.33 During the course of research on cAMP, a second cyclic nucleotide, cyclic guanosine 3′,5′-monophosphate (cGMP), was discovered1 and is now thought to act as a second messenger for the actions of various neurotransmitters, including acetylcholine.

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References

  1. Ashman, D. F., Lipton, R., Melicow, M. M., Price, T. D.: Isolation of adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate from rat urine. Biochem. Biophys. Res. Commun.11:330–334, 1963.

    Article  Google Scholar 

  2. Bering, E. J., Jr.: Cerebrospinal fluid production and its relationship to cerebral metabolism and cerebral blood flow. Am. J. Physiol.197:825–828, 1959.

    Google Scholar 

  3. Butcher, R. W., Sutherland, E. W.: Adenosine 3′,5′-phosphate in biological materials: Purification and properties of cyclic 3′,5′-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3′,5′-phosphate in human urine. J. Biol. Chem.237:1244–1250, 1962.

    Google Scholar 

  4. Chasin, M., Rivkin, I., Mamrak, F., Samaniego, S. G., Hess, S. M.: α-and ß-adrenergic receptors as mediators of accumulation of cyclic adenosine 3′,5′-mon-ophosphate in specific areas of guinea pig brain. J. Biol. Chem.246:3037–3041, 1971.

    Google Scholar 

  5. Cramer, H., Goodwin, F. K., Post, R. M., Bunney W. E.: Effects of probenecid and exercise on cerebro-spinal-fluid cyclic A.M.P. in affective illness (letter). Lancet1:1346–1347, 1972.

    Article  Google Scholar 

  6. Cramer, H., Lindl, T.: Probenecid inhibits efflux of adenosine 3′,5′-monophosphate (cAMP) from cerebrospinal fluid (CSF) in the rat. Psychophannacologia26 (Suppl.):49, 1972 (abstract).

    Google Scholar 

  7. Cramer, H., Ng, L. K. Y., Chase, T. N.: Adenosine 3′,5′-monophosphate in cerebrospinal fluid: Effect of drugs and neurologic disease. Arch. Neurol.29:197–199, 1973.

    Article  Google Scholar 

  8. Cramer, H., Ng, L. K. Y., Chase, T. N.: Effect of probenecid on levels of cyclic AMP in human cerebrospinal fluid. J. Neurochem.19:1601–1602, 1972.

    Article  Google Scholar 

  9. Cserr, H. F.: Relationship between cerebrospinal fluid and interstitial fluid of brain. Fed. Proc. Fed. Am. Soc. Exp. Biol. 33:2075–2078, 1974.

    Google Scholar 

  10. Daly, J. W., Huang, M., Shimizu, H.: Regulation of cyclic AMP levels in brain tissue. Adv. Cyclic Nucleotide Res.1:375–387, 1972.

    Google Scholar 

  11. Flamm, E. S., Schiffer, J., Viau, T. A., Naftchi, E. N.: Alterations of cyclic AMP in cerebral ischemia. Stroke9:400–402, 1978.

    Article  Google Scholar 

  12. Fleischer, A. S., Patton, J. M., Tindall, G. T.: Monitoring intraventricular pressure using an implanted reservoir in head injured patients. Surg. Neurol.3:309–311, 1975.

    Google Scholar 

  13. Fleischer, A. S., Rudman, D. R., Fresh, C. B., Tindall, G. T.: Concentration of 3′,5′ cyclic adenosine monophosphate in ventricular CSF of patients following severe head trauma. J. Neurosurg.47:517–524, 1977.

    Article  Google Scholar 

  14. Greengard, P., Costa, E. (eds): Role of Cyclic AMP in Cell Function: Advances in Biochemistry and Psychopharmacology, Vol. 3. New York, Raven Press, 1970.

    Google Scholar 

  15. Heikkinen, E. R., Myllylä, V. V., Hokkanen, E., Vapaatalo, H.: Cerebrospinal fluid concentration of cyclic AMP in cerebrovascular diseases. Eur. Neurol.14:129–137, 1976.

    Article  Google Scholar 

  16. Heikkinen, E. R., Myllylä, V. V., Vapaatalo, H., Hokkanen, E.: Urinary excretion and cerebrospinal fluid concentration of cyclic adenosine-3′,5′-mono-phosphate in various neurological diseases. Eur. Neurol.11:270–280, 1974.

    Article  Google Scholar 

  17. Heikkinen, E. R., Simila, S., Myllylä, V. V., Hokkanen, E.: Cyclic adenosine-3′,5′-monophosphate concentration and enzyme activities of cerebrospinal fluid in meningitis of children. Z. Kinderheilkd.20:243–250, 1975.

    Article  Google Scholar 

  18. Heikkinen, E. R., Vapaatalo, H., Myllylä, V. V., Hokkanen E.: Role of cyclic AMP in neurological diseases. Presented at the Second International Conference on Cyclic AMP, Vancouver, B.C., 1974.

    Google Scholar 

  19. Kakiuchi, S., Rall, T. W.: The influence of chemical agents on the accumulation of adenosine 3′,5′-mono-phosphate in slices of rabbit cerebellum. Mol. Pharmacol.4:367–378, 1968.

    Google Scholar 

  20. Krishna, G., Forn, J., Voigt, K., Paul, M., Gessa, G. L.: Dynamic aspects of neuro-hormonal control of cyclic 3′,5′-AMP synthesis in brain. Adv. Biochem. Psychopharmacol.3:155–172, 1970.

    Google Scholar 

  21. Marx, J. L.: Cyclic AMP in brain: Role in synaptic transmission. Science178:1188–1119, 1972.

    Article  Google Scholar 

  22. Myllylä, V. V., Heikkinen, E. R., Vapaatalo, H., Hokkanen, E.: Cyclic AMP concentration and enzyme activities of cerebrospinal fluid in patients with epilepsy or central nervous system damage. Eur. Neurol.13:123–130, 1975.

    Article  Google Scholar 

  23. Myllylä, V. V.: Effect of cerebral injury on cerebrospinal fluid cyclic AMP concentration. Eur. Neurol.14:413–425, 1976.

    Article  Google Scholar 

  24. Robison, G. A., Coppen, A. J., Whybrow, P. C, Prance, A. J.: Cyclic A.M.P. in affective disorders (letter). Lancet2:1028–1029, 1970.

    Article  Google Scholar 

  25. Rudman, D. R.: Injection of melatonin into cisterna magna increases concentration of 3′,5′ cyclic guanosine monophosphate in cerebrospinal fluid. Neuroen-docrinology20:235–242, 1976.

    Google Scholar 

  26. Rudman, D., Fleischer, A. S., Jutner, M. S.: Concentration of 3′,5′ cyclic adenosine monophosphate in ventricular cerebrospinal fluid of patients with prolonged coma after head trauma or intracranial hemorrhage. N. Engl. J. Med.295:635–638, 1976.

    Article  Google Scholar 

  27. Rudman, D., Isaacs, J. W.: Effect of intrathecal injection of melantropic-lipolytic peptides on concentration of 3′,5′ cyclic adenosine monophosphate in cerebrospinal fluid. Endocrinology97:1476–1480, 1975.

    Article  Google Scholar 

  28. Rudman, D., O’Brien, M. S., McKinney, A. S., Hoffman, J. C, Patterson, J. H.: Observations on the cyclic nucleotide concentrations in human cerebrospinal fluid. J. Clin. Endocrinol. Metab.42:1088–1097, 1976.

    Article  Google Scholar 

  29. Sattin, A., Rall, T. W.: The effect of adenosine and adenine nucleotides on the cyclic adenosine 3′,5′-phosphate content of guinea pig cerebral cortex slices. Mol. Pharmacol.6:13–23, 1970.

    Google Scholar 

  30. Steiner, A. L., Parker, C. W., Kipnis, D. M.: The measurement of cyclic nucleotides by radioimmu-noassay. Adv. Biochem. Psychopharmacol.3:89–111, 1970.

    Google Scholar 

  31. Sutherland, W. E., Rall, T. W.: Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J. Biol. Chetn.232:1077–1091, 1958.

    Google Scholar 

  32. Sutherland, E. W., Rall, T. W., Menon, T.: Adenyl cyclase: Distribution, preparation, and properties. J. Biol. Chetn.237:1220–1227, 1962.

    Google Scholar 

  33. Sutherland, W. E., Robison, G. A., Butcher, R. W.: Some aspects of the biological role of adenosine 3′,5′-monophosphate (cyclic AMP). Circulation37:279–306, 1968.

    Google Scholar 

  34. Tagashira, Y., Matsuda, M., Welch, K. M. A., Chabi, E., Meyer, J. S.: Effects of cyclic AMP and di-butyryl cyclic AMP on cerebral hemodynamics and metabolism in the baboon. J. Neurosurg.46:484–493, 1977.

    Article  Google Scholar 

  35. Tsang, D., Lal, S., Sourkes, T. L., Ford, R. M., Aranoff, A.: Role of cyclic nucleotides in the nervous system. Med. Biol.52:200–207, 1974.

    Google Scholar 

  36. Vapaatalo, H.: Role of cyclic nucleotides in the nervous system. Med. Biol.52:200–207, 1974.

    Google Scholar 

  37. Watanabe, H., Passonneau, J. V.: Cyclic adenosine monophosphate in cerebral cortex: Alterations following trauma. Arch. Neurol.32:181–184, 1975.

    Article  Google Scholar 

  38. Welch, K. M. A., Meyer, J. S.: Effects of cerebral infarction in man on cyclic AMP levels in CSF and blood. Second International Conference on Cyclic AMP. Vancouver, B.C., 1974.

    Google Scholar 

  39. Welch, K. M. A., Meyer, J. S., Chee, A. N. C.: Evidence for disordered cyclic AMP metabolism in patients with cerebral infarction. Eur. Neurol. 13:144–154, 1975.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, 30322, USA

    Alan S. Fleischer M.D. & George T. Tindall M.D.

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  1. Alan S. Fleischer M.D.
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  2. George T. Tindall M.D.
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Editor information

Editors and Affiliations

  1. Division of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    James H. Wood M.D. (Consultant) (Consultant)

  2. Pediatric Oncology Branch, National Cancer Institute National National Institutes of Health, Bethesda, Maryland, 20205, USA

    James H. Wood M.D. (Consultant) (Consultant)

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© 1980 Plenum Press, New York

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Fleischer, A.S., Tindall, G.T. (1980). Cerebrospinal Fluid Cyclic Nucleotide Alterations in Traumatic Coma. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1039-6_25

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  • DOI: https://doi.org/10.1007/978-1-4684-1039-6_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1041-9

  • Online ISBN: 978-1-4684-1039-6

  • eBook Packages: Springer Book Archive

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