Abstract
Exposure of sensitive cells to purified interferon, from a compatible species, induces a series of biological effects, the best known among these being the antiviral state and the decrease in the rate of cell proliferation. At least one of interferon’s antiviral effects is to inhibit viral protein synthesis (l-3). This inhibition is not immediate but requires several hours of active cellular RNA and protein synthesis before it fully develops. In the past year, interferon was shown to induce, in the treated cells, several new enzymatic activities which regulate protein biosynthesis and produce the translational inhibition observed. These biochemical mechanisms induced by interferon are reviewed here, and tentatively shown as three “pathways” in Figure 1.
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Revel, M., Kimchi, A., Schmidt, A., Shulman, L., Zilberstein, A. (1979). The Interferon System: Studies on the Molecular Mechanism of Interferon Action. In: Pérez-Bercoff, R. (eds) The Molecular Biology of Picornaviruses. NATO Advanced Study Institutes Series, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1000-6_12
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DOI: https://doi.org/10.1007/978-1-4684-1000-6_12
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