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Immunoglobulin E: Biosynthesis and Immunological Mechanisms of IgE-Mediated Hypersensitivity

  • Chapter
Cellular, Molecular, and Clinical Aspects of Allergic Disorders

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 6))

Abstract

The presence of reaginic antibody in the serum of allergic patients was first demonstrated by Prausnitz and Kästner in 1921. The nature of the antibodies, however, remained unknown for 40 years until IgE was found in the serum of hay fever patients and identified as a carrier of reaginic antibody activity (K. Ishizaka et al., 1966a,b; K. Ishizaka and T. Ishizaka, 1967). Indeed, an injection of purified IgE preparation from ragweed-sensitive individuals into normal skin resulted in the sensitization of the skin site for the Prausnitz—Kästner (P-K) reaction, and the removal of IgE antibody from the sera of atopic patients by anti-IgE was accompanied by loss of sensitizing activity. Subsequent studies have shown that association of reaginic activity with IgE is found not only in the ragweed system but also in the other allergen-reagin systems. Antigenic analysis of the immunoglobulin (K. Ishizaka et al., 1967d) and identification of a unique myeloma protein ND as an E myeloma protein (Johansson and Bennich, 1967; Bennich et al., 1969) established that IgE represents a unique immunoglobulin class.

The research was supported by research grants from U.S. Public Health Service, AI-10060, AI-11202, from the National Science Foundation, PCM-74-00857, and from the John A. Hartford Foundation. This is publication No. 313 from O’Neill Laboratories at The Good Samaritan Hospital.

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  1. Department of Medicine and Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21239, USA

    Kimishige Ishizaka & Teruko Ishizaka

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  1. Kimishige Ishizaka
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  1. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Sudhir Gupta M.D., F.R.C.P.(C), F.A.C.P.  & Robert A. Good Ph.D., M.D.  & 

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Ishizaka, K., Ishizaka, T. (1979). Immunoglobulin E: Biosynthesis and Immunological Mechanisms of IgE-Mediated Hypersensitivity. In: Gupta, S., Good, R.A. (eds) Cellular, Molecular, and Clinical Aspects of Allergic Disorders. Comprehensive Immunology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0988-8_5

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