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Effect of Structure on the Interaction of Organophosphorus and Carbamate Esters with Acetylcholinesterase

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Neurotoxicology of Insecticides and Pheromones

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Abstract

The toxicity of organophosphorus and carbamate esters to insects, mammals, and other organisms is attributable to the ability of these materials to inactivate acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of the neurotransmitting agent acetylcholine (ACh) into choline (Ch) and acetic acid. The neurohormone ACh is the synaptic mediator of nerve impulses in the central nervous system of insects as well as the autonomic nervous system in mammals.

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Author information

Authors and Affiliations

  1. University of California, Riverside, CA, 92521, USA

    T. Roy Fukuto

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  1. T. Roy Fukuto
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Medical School, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois, 60611, USA

    Toshio Narahashi

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© 1979 Plenum Press, New York

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Fukuto, T.R. (1979). Effect of Structure on the Interaction of Organophosphorus and Carbamate Esters with Acetylcholinesterase. In: Narahashi, T. (eds) Neurotoxicology of Insecticides and Pheromones. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0970-3_14

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  • DOI: https://doi.org/10.1007/978-1-4684-0970-3_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0972-7

  • Online ISBN: 978-1-4684-0970-3

  • eBook Packages: Springer Book Archive

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