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The Role of Connective Tissue in Atherosclerosis

  • Chapter
Drugs, Lipid Metabolism, and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 109))

Abstract

In man atherosclerosis generally involves the large and medium sized arteries in which connective tissue proteins comprise more than half the dry weight. Connective tissue contributes to some of the most important alterations in the significant human lesion, the fibrous plaque. It is this lesion which poses the most serious threat to health and life. As recently reviewed by Smith and Smith (1), it is still open to debate whether or not fibrous plaques, or at least some of them, develop from fatty streaks. We, therefore, will restrict our discussion to fibrous lesions. Fibrous lesions begin to develop in the second to third decade of life in almost all individuals of our type of society. However, it takes decades of slow growth before they produce clinical symptoms.

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Authors and Affiliations

  1. Cardiovascular Institute, Boston University Medical Center, Boston, Massachusetts, USA

    Dieter M. Kramsch M.D

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  1. Dieter M. Kramsch M.D
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  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti

  3. Division of Research, The Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes

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Kramsch, D.M. (1978). The Role of Connective Tissue in Atherosclerosis. In: Kritchevsky, D., Paoletti, R., Holmes, W.L. (eds) Drugs, Lipid Metabolism, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 109. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0967-3_9

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