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Lipoprotein Lipase

  • Chapter
Heparin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 52))

Abstract

Intravenous injection of heparin releases lipase activity from tissue sites to the circulating blood (8, 20, 30, 31, 34). One major enzyme activity released is the so-called lipoprotein lipase (LPL). This enzyme is inhibited by high salt concentration, and its activity against long-chain triglycerides is greatly enhanced by a serum component (31) identified as the apolipoprotein CII (also called R-Glu or apo-LP-Glu) of the very low-density lipoproteins (9, 23, 36). Enzymes with these characteristics are present in several tissues — e.g., adipose tissue (34), skeletal and heart muscle (31), and lac- tating mammary gland (47) — and, in some species, in milk (24, 33). They probably have an important role in the metabolism of the triglyceride-rich plasma lipoproteins (42). Electron microscopic and other studies indicate that in some tissues these lipoproteins can attach to the capillary endothelium, where they are then acted on by LPL C5). The triglycerides are hydrolyzed, and fatty acids and possibly also partial glycerides are transferred into the tissue through the capillary endothelium, leaving a remnant lipoprotein, a particle that has lost most of its triglyceride. This remnant lipoprotein is further metabolized by other, less well-known systems.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Umeå University, Umeå, Sweden

    Thomas Olivecrona, Olle Hernell & Torbjörn Egelrud

Authors
  1. Thomas Olivecrona
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  2. Olle Hernell
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  3. Torbjörn Egelrud
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Editor information

Editors and Affiliations

  1. Department of Biological Chemistry, Washington University School of Medicine, St. Louis, Missouri, USA

    Ralph A. Bradshaw

  2. Department of Medicine, The Jewish Hospital, St. Louis, Missouri, USA

    Stanford Wessler

  3. Washington University School of Medicine, St. Louis, Missouri, USA

    Stanford Wessler

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© 1975 Plenum Press, New York

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Olivecrona, T., Hernell, O., Egelrud, T. (1975). Lipoprotein Lipase. In: Bradshaw, R.A., Wessler, S. (eds) Heparin. Advances in Experimental Medicine and Biology, vol 52. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0946-8_24

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  • DOI: https://doi.org/10.1007/978-1-4684-0946-8_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0948-2

  • Online ISBN: 978-1-4684-0946-8

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