Abstract
In the mammalian central nervous system, Lipids comprise over half of the total dry weight. Almost all of the Lipids in the CNS are found in membranes of cells. These brain Lipids are constantly being synthesized, replacing other lipid molecules in the membranes. Neurons and glia seem to have a characteristic lipid profile. Different types of membranes accumulate different types of Lipids. As a result of changes in numbers of neurons and glia with age and other factors, a continuous change in lipid composition and particularly in the acyl groups of the brain Lipids has been observed with age. In primates, the lipid content rises during development, remains relatively constant during maturity, and then falls during aging. Marked decreases in the rate of brain lipid metabolism with increasing age have also been reported.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bazan, N. G., J. Neurochem., 18: 1379–1385, 1971.
Burger, M. Mediziniche, 1: 561–567, 1956.
Freysz, L., Lastennet, A. & Mandel, P., J. Neurochem. 19: 2599–2605, 1972.
Gershon, H. & Gershon, D., Proc. Nat. Acad. Sci. U.S.A., 70: 909–913, 1973.
Horrocks, L. A., J. Neurochem. 15: 483–488, 1968.
Horrocks, L. A., In: Neurobiological Aspects of Maturation and Aging, Progress in Brain Research, (Ed. Ford, D.H. ), Elsevier, Amsterdan, 1973.
Kabara, J. J., In: Neurobiological Aspects of Maturation and Aging, Progress in Brain Research, (Ed. Ford, D. H. ), Elsevier, Amsterdam, 1973.
Leeden, R. J. Am. Oil Chemists’ Soc., 43: 57, 1966.
Merat, A. and Diekerson, J.W.T. J. Neurochem., 20: 873–880, 1973.
Norton, W. T. and Poduslo, S. E. J. Neurochem., 21: 759, 1973.
Price, G. B. and Makinodan, T. Gerontologia 19: 58–70.
Rawlins, F. A. and Smith, M. E. Neurochem., 18: 1, 1961.
Rosenberg, A. In: Inborn disorders of sphingolipid metabolism. (Eds. Volk, B. W. and Aronson, S. M. ), Pergamon Press, New York, 1967.
Rouser, G. and Yamamoto, A. Lipids, 3: 284–287, 1968.
Rouser, G. and Yamamoto, A. In: Handbook of Neurochemistry. (Ed. Lajtha, A.), Vol. 1, Plenum Press, New York, 1969.
Rouser, G., Yamamoto, A. and Kritchevsky, G. In: Chemistry and Brain Development. (Eds. Paoletti, R. and Davison, A. N. ), Plenum Press, New York, 1971.
Rouser, G., Kritchevsky, G. and Yamamoto, A. In: Advances in Lipid Research. (Eds. Paoletti, R. and Kritchevsky, D.), Vol. 10, Academic Press, New York, 1972.
Sun, G. Y. and Horrocks, L. A. Lipids, 5: 1006–1012, 1970.
Sun, G. Y. and Horrocks, L. A. Federation Proceedings, 30: 1248, 1971 (Abstract).
Sun, G. Y. and Samorajski, T. J. Gerontology, 27: 10–17, 1972.
Sun, G. Y. and Samorajski, T. Biochemica et Biophysica Acta, 316: 19, 1973.
Suzuki, K. J. Neurochem., 12: 969, 1965.
Svennerholm, L. J. Lipid Res., 9: 570–579, 1968.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Horrocks, L.A., Sun, G.Y., D’Amato, R.A. (1975). Changes in Brain Lipids During Aging. In: Ordy, J.M., Brizzee, K.R. (eds) Neurobiology of Aging. Advances in Behavioral Biology, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0925-3_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-0925-3_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-0927-7
Online ISBN: 978-1-4684-0925-3
eBook Packages: Springer Book Archive