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Clinical Implications of Bile Acid Metabolism in Man

  • Chapter
The Bile Acids, Chemistry, Physiology, and Metabolism

Abstract

Cholesterol molecules once formed in the body or absorbed from the diet can be eliminated from the human organism primarily by the gastrointestinal route as such or after conversion to bile acids. The latter are synthesized exclusively in the liver via a series of reactions which are initiated by 7α-hydroxylation of cholesterol (1). Bile acids subsequently formed are called “primary bile acids,” in contrast to “secondary bile acids,” which are formed by intestinal microorganisms from the primary ones during the enterohepatic circulation.

The investigation is being carried out under a contract with the Association of Finnish Life Assurance Companies.

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  1. Third Department of Medicine, University of Helsinki, Helsinki, Finland

    Tatu A. Miettinen

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  1. Biochemistry Research Division, Department of Medicine, Sinai Hospital of Baltimore, Inc., Balimore, Maryland, USA

    Padmanabhan P. Nair

  2. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

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Miettinen, T.A. (1973). Clinical Implications of Bile Acid Metabolism in Man. In: Nair, P.P., Kritchevsky, D. (eds) The Bile Acids, Chemistry, Physiology, and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0898-0_7

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