Abstract
It is difficult to demonstrate the precise etiology of chromosomal damage in man because of the great variety and environmental ubiquity of the agents—drugs, chemicals, viruses, and physical forces—known or suspected to cause chromosomal breakage and consequent aberrations. While the researcher has findings available from a vast array of tests, ranging from in vitro bacterial experiments and sophisticated chemical studies to large-scale utilization of laboratory animals, valid extrapolation of these findings to man is often impossible. Even the demonstration of experimentally mutagenic compounds, or their metabolites, to be present in human tissue does not give conclusive evidence of either damage or damage-repair. Specifically human findings are available from a limited number of accidental or clinical exposures to chromosome-breaking, or clastogenic,(1) agents, but these data are conflicting, fragmentary, and difficult to approximate to the workaday world.
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Kilian, D.J., Picciano, D. (1976). Cytogenetic Surveillance of Industrial Populations. In: Hollaender, A. (eds) Chemical Mutagens. Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0892-8_9
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DOI: https://doi.org/10.1007/978-1-4684-0892-8_9
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