Abstract
Envenomation from bite by the Habu snake (Trimeresunis flavoviridis), a crotalid, can be cured effectively if antivenin is administered soon after the bite. However, victims often suffer from residual symptoms such as hemorrhage and necrosis starting at the site of bite when they fail to receive immediate medical treatment (Sawai et al., 1962). Prophylaxis by active immunization with toxoid has long been required, particularly for the inhabitants of remote islands.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kondo, H., Kondo, S., Sadahko, S., Yamauchi, K., Ohsaka, A., and Murata, R. (1965a). Standardization of antivenine. I. A method for determination of antilethai potency of Habu antivenine, Japan. J. Med. Sci. Biol. 18: 101–110.
Kondo, H., Kondo, S., Sadahuro, S., Yamauchi, K., Ohsaka, A., and Murata, R. (1965b). Standardization of antivenine. II. A method for determination of antihemorrhagic potency of Habu antivenine in the presence of two hemorrhagic principles and their antibodies, Japan. J. Med. Sci. Biol. 18: 127–141.
Kondo, H., Sadahiro, S., Kondo, S., Yamauchi, K., Honjo, S., Cho, F., Ohsaka, A., and Murata, R. (1970). Immunogenicity in monkeys of a combined toxoid from the main toxic principles separated from Hahu snake venom, Japan. J.Med. Sci. Biol. 23: 413–418.
Kondo, H., Sadahiro, S., Kondo, S., Yamauchi, K., and Murata, R. (1971a). Immunogenicity of a toxoid of Habu (Trimeresunis flavoviridis) venom in various animal species including man, Japan. J. Med. Sci. Biol. 24: 365–377.
Kondo, S., Sadahiro, S., Yamauchi, K., Kondo, H., and Murata, R. (1971b). Preparation and standardization of toxoid from the venom of Trimeresurus flavoviridis (Habu), Japan. J Med. Sci. Biol. 24: 281–294.
Kondo, H., and Murata, R. (1972). Preparation and Standardization of formol toxoid from the venom of Trimeresurus flavoviridis (Habu), J. Formosan Med. Assoc. 71: 413–419.
Kondo, H., Kondo, S., Sadahiro, S., Yamauchi, K., Ohsaka, A., Murata, R., Hokama, Z., and Yamakawa, M. (1972). Estimation by a new method of the amount of venom ejected by a single bite of Trimeresurus species, Japan. J. Med. Sci. Biol. 25: 123–131.
Kondo, H., Kondo, S., Sadahiro, S., Yamauchi, K., Ohsaka, A., and Murata, R. (1973). Preparation and immunogenicity of Habu (Trimeresurus flavoviridis) toxoid, in Toxin of Animal and Plant Origin (DeVries, A., and Kochva, E., eds.). Vol. 3, Gordon and Breach, London, pp. 845–862.
Ohsaka, A., Ikezawa, H., Kondo, H., Kondo, S., and Uchida, N. (1960). Hemorrhagic activities of Habu snake venom, and their relations to lethal toxicity, proteolytic activities and other pathological activities, Brit. J. Exptl. Pathol. 41: 478–486.
Omori-Satoh, T., Ohsaka, A., Kondo, S., and Kondo, H. (1967). A simple and rapid method for separating two hemorrhagic principles in the venom of Trimeresurus flavoviridis, Toxicon 5 : 17–24.
Omori-Satoh, T., and Ohsaka, A. (1970). Purification and some properties of hemorrhagic principles 1 in the venom of Trimeresurus flavoviridis, Biochim. Biophys. Acta 207: 432–444.
Sadahiro, S., Kondo, S., Yamauchi, K., Kondo, H., and Murata, R. (1970). Studies on immunogenicity of toxoids from Habu (Trimeresurus flavoviridis) venom, Japan. J. Med. Sci. Biol. 23: 285–289.
Sawai, Y., Makmo, M., Tateno, I., Okonogi, T., and Mitsuhashi, S. (1962). Studies on thè improvement of treatment of Habu snake (Trimeresurus flavoviridis) bite. 3. Clinical analysis and medical treatment of Habu snake bite on the Amami Islands, Japan. J. Exptl Med. 32: 117–138.
Someya, S., Murata, R., Sawai, Y., Kondo, H., and Ishu, A. (1972). Active immunization of man with toxoid of Habu (Trimeresurus flavoviridis) venom, Japan. J. Med. Set Biol. 25:47–51.
Takahashi, T., and Ohsaka, A. (1970a). Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity, Biochim. Biophys. Acta 198: 293–307.
Takahashi, T., and Ohsaka, A. (1970b). Purification and some properties of two hemorrhagic principles (HR2a and HR2b) in the venom of Trimeresurus flavoviridis; complete separation of the principles from proteolytic activity, Biophys. Acta 207: 65–75.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Kondo, S., Sadahiro, S., Murata, R. (1976). Relationship between the Amount of Habu Toxoid Injected into the Monkey and the Resulting Antitoxin Titer in the Circulation. In: Ohsaka, A., Hayashi, K., Sawai, Y., Murata, R., Funatsu, M., Tamiya, N. (eds) Animal, Plant, and Microbial Toxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0889-8_37
Download citation
DOI: https://doi.org/10.1007/978-1-4684-0889-8_37
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-0891-1
Online ISBN: 978-1-4684-0889-8
eBook Packages: Springer Book Archive