Abstract
Bee venom has gained popularity in some European countries as an antirheumatic drug. Its healing effect has been known from time immemorial. The encouraging therapeutic results obtained by healers who practiced bee stinging as well as the application of modern pharmaceuticals could hardly be accounted for by the scarce pharmacological data on the mechanism of its action. The venom-induced activation of the hypophysocorticorenal system was believed to be the major phenomenon involved (Shkenderov et al., 1968; Shkenderov, 1971). In line with the concept of its anti-inflammatory effect, were the uncoupling of oxidative phosphorylation and the degranulation of mast cells leading to histamine release (Habermann, 1954; Breithaupt and Habermann, 1968). The radioprotective effect of the venom discovered by Shipman and Cole (1967) aroused deep interest but increased the problems about the mechanism of its action. In the meantime, a number of tests and criteria were elaborated for the evaluation of nonsteroid antirheumatic drugs; some tests are related to the pharmacobiochemical bases of their actions.
Keywords
- Protease Inhibitor
- Adjuvant Arthritis
- Venom Component
- Serum Haptoglobin
- Ammonium Formate Buffer
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, access via your institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bertelh, A., Donati, L., and Marek, J. (1969). Protease in inflammatory reactions, in Inflammation, Biochemistry, and Drug Interaction (Bartelli, A., and Houck, J. C., eds.), Excerpta Med. Foundat., Amsterdam, pp. 66–75.
Breithaupt, H., and Habermann, E. (1968). Mastzelldegranuherendes Peptid (MCD-peptid) aus Bienengift: isoherung, biochemische und pharmakologische Eigenschaften, Naunyn-Schmied. Arch. Pharmacol. Exptl. Pathol.\ 261: 252–270.
Chase, M. W. (1945). The cellular transfer of cutaneous hypersensitivity to the tuberculin, Proc. Soc. Exptl. Biol. Med.\ 59: 134–141.
Cunningham, A. J. (1965). A method of increasing sensibiUty for detecting single antibody forming cells, Nature 207: 1106–1108.
David, J. R., Al-Askaris, S., Lawrence, H. S., and Thomas, L. (1964). Delayed hypersensitivity in vitro.\ I. The specificity of inhibition of cell migration by antigens, J. Immunol.\ 93:264–273.
Di Rosa, M., Papadimitriou, J. M., and Willonghby, D. A. (1971). A histopathological and pharmacological analysis of the mode of action of non-steroidal anti-inflammatory drugs, J. Pathol.\ 105: 239–256.
Ferreira, S. H., and Vane, J. R. (1974). New aspects of the mode of action of nonsteroid anti-inflammatory drugs, Ann. Rev. Pharmacol.\ 15:57–74.
Förster, O. (1969). Proteases in inflammation. On the possible mode of action of the protease inhibitor trasylol in: Inflammation, Biochemistry, and Drug Interaction (Bertelh, A., and Houck, J. C., eds.), Excerpta Med. Foundat., Amsterdam, pp. 53–65.
Fritz, H., Trautschold, I., and Werle, E. (1970). Protease inhibitoren, in Methoden der Enzymatischen Analyse (Bergmeyer H. U., ed.) 2nd ed., Akademie Verlag, Berlin, pp.1021–1038.
Ginetis, A. A., Winopadowa, S. A., and Worobjow, W. J. (1968). The change of the histone composition at early stages of embriogenesis sea urchin and leach, Cytologia 10: 581–583.
Görög, P., and Kovacs, I. B. (1970). The inhibitory effect of nonsteroidal anti-inflammatory agents on aggregation of red cells in vitro, J. Pharm. Pharmacol.\ 22: 86–92.
Habermann, E. (1954). Hemmung der oxydativen phosphoryherung durch tierische gifte, Naturwissenschaften 41: 429–430.
Hanson, Jennifer M., Morley, J., and Soria-Herrera, C. (1974). Anti-inflammatory property of 401/MCD-peptide/. A peptide from the venom of the beeApis mellifera (L), Brit. J. Pharmacol.\ 50: 383–392.
Kaller, H., Hoffmeister, F., und Kroneberg, G. (1966). Die wkkung von Trasylol auf verschiedene odemformen der Rattenpfote, Arch. Int. Pharmacodyn.\ 161: 398–409.
Kato, K., Yoshida, K., Tsukamoto, H., Nobumaga, M., Masuya, T., and Sawada, T. (1960). Chem. Pharmacol. Bull. (Tokyo) 8: 239, accord, to Methoden der Enzymatischen Analyse, (Bergmeyer, H. U., ed., 2nd ed. Akademie Verlag, Berün, 1970, pp. 889–891.
Kosturkov, G., and Shkenderov, S. V. (1974). Effect of bee venom on anumber of hemolysin-producing cells, of mouse spleens at primary immunization with ram erythrocytes, Compt. Rend. Acad. Bulg. Sci.\ 21: 1295–1296.
Laurentaci, G. (1969). An experimental approach to the use of a proteolytic enzyme inhibitor as an anti-inflammatory drug, in Inflammation Biochemistry and Drug Interaction, (Bertelh, A., and Houck, J. C., eds.) Excerpta Med. Foundat., Amsterdam, pp.330–333.
Mizushima, L, and Kobayashi, M. (1968). Interaction of anti-inflammatory drugs with serum proteins especially with some biologically active proteins, J. Pharmacol.\ 20: 169–173.
Mizushima, I., and Suzuki, H. (1965). Interaction between plasma proteins and antirheumatic or new anti-phlogistic Dmgs. Arch. Int. Pharmacodyn.\ 157:115–124.
Ovcharov, R., Shkenderov, S., and Michaüova, S. (1976). Studies on anti-inflammatory effect of apamin, Toxicon (in press)
Owen, J. A., Better, F. C., and Hoban, J. (1960). A simple method for the determination of serum haptoglobm, J. clin. Pathol.\ 13: 163–164.
Paulus, H. E., and Wnitehouse, I. (1973). Nonsteroid anti-inflammatory agents, Ann. Rev. Pharmacol.\ 13: 107–125.
Seidel, G., Stiicker, H. U., and Vogt, W. (1971). Significance of direct and mdirect kmin formation by plasmin in human plasma., Biochem. Pharmacol.\ 20: 1859–1867.
Shipman, W. H., and Cole, L. J. (1967). Increased resistance of mice to x-irradiation after the injection of bee Venom, Nature 215: 311–312.
Shkenderov, S. (1971). A study on the effect of the components of the bee venom on the activity of the adrenal cortex, Izv. DIKLS 1: 34–39.
Shkenderov, S. (1973). A protease inhibitor in bee venom. Identification, partial purification and some properties, FEBS Letters 33: 343–347.
Shkenderov, S. (1975). Further purification, inhibitory spectrum, and some kinetic properties of protease inhibitor in bee venom, in Animal, Plants, and Microbial Toxins (Ohsaka et al.\, eds.). Vol. 1, Plenum Press, New York, pp. 263–272.
Shkenderov, S., Nikolov, S., and Kirov, M. (1968). Therapeutic apphcation of bee venom, Savremenna Medicina 2: 172–176.
Veremeenko, K. H. (1971). Proteolytic enzymes and its inhibitories in medical practice, Zdorovia, Kiev.
Weissmann, G., Becker, B., and Thomas, L. (1964). Studies on lysosomes. Effect of streptolysins and other hemolytic agents on isolated leucocyte granules, J. Cell. Biol.\ 22: 115–121.
Winzler, R. I., Devor, A. W., Mehl, W., and Smyth, I. M. (1948). Studies on the mucopro- teins of human plasma. 1. Determination and isolation, J. Clin. Invest.\ 27: 609–703.
Zurier, K. B., and Weissmann, G. (1972). Effect of prostaglandins upon enzyme release from lysosomes and experimental arthritis, in Prostaglandins in cellular biology (Phariss, K. B., and Ramwell, J., eds.), Plenum Press, New York, pp. 151–169.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Shkenderov, S. (1976). New Pharmacobiochemical Data on the Anti-Inflammatory Effect of Bee Venom. In: Ohsaka, A., Hayashi, K., Sawai, Y., Murata, R., Funatsu, M., Tamiya, N. (eds) Animal, Plant, and Microbial Toxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0889-8_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-0889-8_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-0891-1
Online ISBN: 978-1-4684-0889-8
eBook Packages: Springer Book Archive