Bee venom has gained popularity in some European countries as an antirheumatic drug. Its healing effect has been known from time immemorial. The encouraging therapeutic results obtained by healers who practiced bee stinging as well as the application of modern pharmaceuticals could hardly be accounted for by the scarce pharmacological data on the mechanism of its action. The venom-induced activation of the hypophysocorticorenal system was believed to be the major phenomenon involved (Shkenderov et al., 1968; Shkenderov, 1971). In line with the concept of its anti-inflammatory effect, were the uncoupling of oxidative phosphorylation and the degranulation of mast cells leading to histamine release (Habermann, 1954; Breithaupt and Habermann, 1968). The radioprotective effect of the venom discovered by Shipman and Cole (1967) aroused deep interest but increased the problems about the mechanism of its action. In the meantime, a number of tests and criteria were elaborated for the evaluation of nonsteroid antirheumatic drugs; some tests are related to the pharmacobiochemical bases of their actions.
- Protease Inhibitor
- Adjuvant Arthritis
- Venom Component
- Serum Haptoglobin
- Ammonium Formate Buffer
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Shkenderov, S. (1976). New Pharmacobiochemical Data on the Anti-Inflammatory Effect of Bee Venom. In: Ohsaka, A., Hayashi, K., Sawai, Y., Murata, R., Funatsu, M., Tamiya, N. (eds) Animal, Plant, and Microbial Toxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0889-8_28
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