Skip to main content
SpringerLink
Log in
Book cover

Immunoglobulins pp 357–372Cite as

Lymphocyte Membrane Immunoglobulins: An Overview

  • Chapter

  • 155 Accesses

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 5))

Abstract

Selective concepts of antibody formation imply that preformed antibodies are present as receptors on the membrane of immunocytes and are instrumental, after interaction with the corresponding antigens, in triggering these cells to undergo a series of events that ultimately lead to antibody production. This view of the physiology of the immune response was first put forward by Ehrlich (1900), who visualized polyvalent immunocytes, each carrying on its membrane a variety of receptors for antigens; the interaction of antigen with one kind of these receptors induced a “compensatory” hyperproduction of the receptors, which then spilled into the body fluids as soluble antibodies. Almost 60 years later Burnet (1959) proposed a similar concept, but with one major difference, namely, that the combining property of the receptors present on the membrane of one cell is uniform, and that the interaction of these receptors with the corresponding antigen determines this cell to clonal expansion or deletion with the corresponding consequences of antibody production or tolerance.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abney, E. R., Keeler, K. D., Parkhouse, R. M. E., and Willcox, H. N. A., 1976, Immunoglobulin M receptors on memory cells of IgG antibody-forming cell clones, Eur. J. Immunol. 6: 443–450.

    Google Scholar 

  • Andersson, J., Bullock, W. W., and Melchers, F., 1974, Inhibition of mitogenic stimulation of mouse lymphocytes by anti-mouse immunoglobulin antibodies, Eur. J. Immunol. 4: 715–722.

    Article  PubMed  CAS  Google Scholar 

  • Beale, G. H., 1954, The Genetics of Paramecium aurelia, Cambridge University Press, Cambridge, England.

    Google Scholar 

  • Burnet, F. M., 1959, The Clonal Selection Theory of Acquired Immunity, Cambridge University Press, Cambridge, England.

    Google Scholar 

  • Cambier, J. C., Vitetta, E. S., Kettmann, J. R., Wetzel, G. M., and Uhr, J. W., 1977, B cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells, J. Exp. Med. 146: 107–117.

    Article  PubMed  CAS  Google Scholar 

  • Chess, L., Levine, H., McDermott, R. P., and Schlossman, S. F., 1975, Immunologic function of isolated human lymphocyte subpopulations. VI. Further characterization of the surface-Ig-negative, Erosette-negative (null cell) subset, J. Immunol. 115: 1483–1487.

    PubMed  CAS  Google Scholar 

  • Cooper, M. D., Kearney, J. F., Lawton, A. R., Abney, E. R., Parkhouse, R. M. E., Preud’homme, J. L., and Seligman, M., 1976, Generation of immunoglobulin class diversity in B cells: A discussion with emphasis on IgD development, Ann. Immunol. (Inst. Pasteur) 127C: 573–581.

    CAS  Google Scholar 

  • Corte, G., Ferrarini, M., Tonda, P., Bargellesi, A., and Pernis, B., 1978, Membrane lgD on monkey lymphocytes, Eur. J. Immunol. (in press).

    Google Scholar 

  • Czaja, M. J., Richards, F. F., and Varga, J. M., 1977, Multispecific lymphoid Cell Surface Receptors. Proc. Natl. Acad. Sci. U.S.A. 74: 1224–1228.

    Article  PubMed  CAS  Google Scholar 

  • De Luca, D., Miller, A., and Sercarz, E., 1975, Antigen binding to lymphoid cells from unimmunized mice. II. High frequency of antigen binding cells for several protein antigens by a morphologically distinct Igbearing population of T and B lymphocytes, Cell. Immunol. 18: 255–273.

    Article  Google Scholar 

  • Ehrlich, P., 1900, Croonian lecture: On immunity with special reference to cell life, Proc. R. Soc. London Ser. B 66: 424–448.

    CAS  Google Scholar 

  • Fanger, M. W., Hart, D. A., Wells, J. V., and Nisinoff, A., 1970, Requirement for cross-linkage in the stimulation of transformation of rabbit peripheral lymphocytes by antiglobulin reagents, J. Immunol. 105: 1484–1492.

    PubMed  CAS  Google Scholar 

  • Forni, L., and Pernis, B., 1975, Interactions between Fc receptors and membrane immunoglobulins on B lymphocytes, in: Membrane Receptors of Lymphocytes ( M. Seligmann, J. L. Preud’homme, and F. M. Kourilsky, eds.), pp. 193–202, North-Holland, Amsterdam and Oxford.

    Google Scholar 

  • Fröland, S. S., and Natvig, J. B., 1972, Class, subclass, and allelic exclusion of membrane-bound Ig of human B lymphocytes, J. Exp. Med. 136: 409–414.

    Article  PubMed  Google Scholar 

  • Fu, S. M., and Kunkel, H. G., 1974, Membrane immunoglobulins of B lymphocytes: Inability to detect certain characteristic IgM and IgD antigens, J. Exp. Med. 140: 895–903.

    Article  PubMed  CAS  Google Scholar 

  • Fu, S. M., Winchester, R. J., Feizi, T., Walzer, P. D., and Kunkel, H. G., 1974, Idiotype specificity of surface immunoglobulin and the maturation of leukemic bone-marrow derived lymphocytes, Proc. Natl. Acad. Sci. U.S.A. 71: 4487–4490.

    Article  PubMed  CAS  Google Scholar 

  • Fuji, H., and Jerne, N. K., 1969, Primary immune response in vitro: Reversible suppression by anti-globulin antibodies, Ann. Inst. Pasteur 117: 801–805.

    CAS  Google Scholar 

  • Ferrarini, M., Corte, G., Viale, G., Durante, M. L., and Bargellesi, A., 1976a, Membrane Ig on human lymphocytes: Rate of turnover of IgD and IgM on the surface of human tonsil cells, Eur. J. Immunol. 6: 372–378.

    Article  PubMed  CAS  Google Scholar 

  • Ferrarini, M., Viale, G., Risso, A., and Pernis, B., 1976b, A study of the immunoglobulin classes present on the membrane and in the cytoplasm of human tonsil plasma cells, Eur. J. Immunol. 6: 562–565.

    Article  PubMed  CAS  Google Scholar 

  • Greaves, M. F., 1970, Biological effects of anti-immunoglobulins: Evidence for immunoglobulin receptors on T and B lymphocytes, Transplant. Rev. 5: 45.

    PubMed  CAS  Google Scholar 

  • Jones, P. P., Cebra, J. J., and Herzenberg, L. A., 1974, Restriction of gene expression in B lymphocytes and their progeny. II. Commitment to immunoglobulin allotype, J. Exp. Med. 139: 581–599.

    Article  PubMed  CAS  Google Scholar 

  • Julius, M. H., and Herzenberg, L. A., 1974, Isolation of antigen binding cells from unprimed mice: Demonstration of antibody-forming cell precursor, activity and correlation between precursor and secreted antibody avidities, J. Exp. Med. 140: 904–920.

    Article  PubMed  CAS  Google Scholar 

  • Julius, M. H., Janeway, C. A., and Herzenberg, L. A., 1976, Isolation of antigen binding cells from unprimed mice. II. Evidence for monospecificity of antigen binding cells, Eur. J. Immunol. 6: 288–292.

    Article  PubMed  CAS  Google Scholar 

  • Kearney, J. F., Cooper, M. D., and Lawton, A. R., 1976, B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by anti-mouse immunoglobulin antibodies, J. Immunol. 116: 1664–1668.

    PubMed  CAS  Google Scholar 

  • Kishimoto, T., and Ishizaka, K. J., 1975, Regulation of antibody response in vitro. IX. Induction of secondary anti-hapten IgG antibody response by anti-immunoglobulin and enhancing soluble factor, J. Immunol. 114: 585–591.

    PubMed  CAS  Google Scholar 

  • Lawton, A. R., Selg, K. S., Royal, S. A., and Cooper, M. D., 1972, Ontogeny of B lymphocytes in the human fetus, Clin. Immunol. Immunopathol. 1: 84–93.

    Article  Google Scholar 

  • Lerner, R. A., McConhaey, P. J., Jansen, I., and Dixon, F. J., 1972, Synthesis of plasma-membrane associated and secretory immunoglobulins in diploid lymphocytes, J. Exp. Med. 135: 136–149.

    Article  PubMed  CAS  Google Scholar 

  • Lesley, J., and Dutton, R. W., 1970, Antigen receptor molecules: Inhibition by antiserum against kappa light chains, Science 169: 487–488.

    Article  PubMed  CAS  Google Scholar 

  • Litwin, S. D., 1972, Allelic and class exclusion of membrane-associated immunoglobulins of human lymphocytes, J. Immunol. 108: 1129–1131.

    PubMed  CAS  Google Scholar 

  • Loor, F., Forni, L., and Pernis, B., 1972, The dynamic state of the lymphocyte membrane: Factors affecting the distribution and turnover of surface immunoglobulins, Eur. J. Immunol. 2: 203–212.

    Article  PubMed  CAS  Google Scholar 

  • Melchers, F., and Andersson, J., 1973, Synthesis, surface deposition and secretion of immunoglobulin M in bone-marrow derived lymphocytes, before and after mitogenic stimulation, Transplant, Rev. 14: 76–130.

    CAS  Google Scholar 

  • Mitchison, N. A., 1967, Antigen recognition responsible for the induction in vitro of the secondary response, Cold Spring Harbor Symp. Quant. Biol. 32: 431–440.

    Article  CAS  Google Scholar 

  • Mond, J. J., Takahashi, R., and Thorbecke, G. J., 1972, Surface antigens of immunocompetent cells. III. In vitro studies of the role of B and T cells in immunological memory, J. Exp. Med. 136: 663–675.

    Article  PubMed  CAS  Google Scholar 

  • Moretta, L., Ferrarini, M., Durante, M. L., and Mingari, M. C., 1975, Expression of a receptor for IgM by human T cells in vitro, Eur. J. Immunol. 5: 565–569.

    Article  PubMed  CAS  Google Scholar 

  • Nagy, Z., Elliot, B. E., Nabholz, M., Krammer, P. H., and Pernis, B., 1976, Surface binding of alloantigens to T cells activated in the mixed lymphocyte reaction, J. Exp. Med. 143: 648–659.

    Article  PubMed  CAS  Google Scholar 

  • Okumura, K., Julius, M. H., Tsu, T., Herzenberg, L. A., and Herzenberg, L. A., 1976, Demonstration that IgG memory is carried by IgG-bearing cells, Eur. J. Immunol. 6: 467–472.

    Article  PubMed  CAS  Google Scholar 

  • Old, L. J., Stockert, E., Boyse, E. A., and Kim, J. H., 1968, Loss of TL antigens from cells exposed to TL antibody: Study of the phenomenon in vitro, J. Exp. Med. 127: 523–539.

    Article  PubMed  CAS  Google Scholar 

  • Owen, J. J. T., Raff, M. C., and Cooper, M. D., 1975, Studies on the generation of B lymphocytes in the mouse embryo, Eur. J. Immunol. 5: 468–473.

    Article  Google Scholar 

  • Owen, J. J. T., Wright, D. E., Habu, S., Raff, M. C., and Cooper, M. D., 1977, Studies on the generation of B lymphocytes in fetal liver and bone-marrow, J. Immunol. 118: 2067–2072.

    PubMed  CAS  Google Scholar 

  • Pernis, B., 1976, IgD Receptors, in: Immunopathology VII: International Symposium, Bad Schachen, Germany ( P. Miescher, ed.), pp. 74–81, Schwabe and Co., Basel and Stuttgart.

    Google Scholar 

  • Pernis, B., 1977, Lymphocyte membrane IgD, Immunological Reviews 37: 210–218.

    Article  PubMed  CAS  Google Scholar 

  • Pernis, B., Forni, L., and Amante, L., 1970, Immunoglobulin spots on the surface of rabbit lymphocytes, J. Exp. Med. 132: 1001–1018.

    Article  PubMed  CAS  Google Scholar 

  • Pernis, B., Forni, L., and Amante, L., 1971, Immunoglobulins as cell receptors, Ann. N. Y. Acad. Sci. 190: 420–429.

    Article  PubMed  CAS  Google Scholar 

  • Pernis, B., Miller, J. F. A. P., Forni, L., and Sprent, J., 1974a, Immunoglobulin on activated T cells detected by indirect immunofluorescence, Cell. Immunol. 10: 476–482.

    Article  PubMed  CAS  Google Scholar 

  • Pernis, B., Brouet, J. C., and Seligmann, M., 1974b, IgD and IgM on the membrane of lymphoid cells in macroglobulinemia: Evidence for identity of membrane IgD and IgM antibody activity in a case with anti-IgG receptors, Eur. J. Immunol. 4: 776–778.

    Article  PubMed  CAS  Google Scholar 

  • Pernis, B., Forni, L., and Luzzati, A. L., 1977, Synthesis of multiple immunoglobulin classes by single lymphocytes, Cold Spring Harbor Symp. Quant. Biol. 41: 175–183.

    Article  PubMed  Google Scholar 

  • Pierce, C. W., Solliday, S. M., and Asofsky, R., 1972a, Immune responses in vitro. IV. Suppression of primary yM, yG and yA plaque-forming cell responses in mouse cell cultures by class-specific antibody to mouse immunoglobuline, J. Exp. Med. 135: 675–697.

    Article  PubMed  CAS  Google Scholar 

  • Pierce, C. W., Solliday, S. M., and Asofsky, R., 1972b, Immune responses in vitro. V. Supression of y-M, y-G and yA plaque-forming cell responses in cultures of primed mouse spleen cells by class-specific antibody to mouse immunoglobulins, J. Exp. Med. 135: 698–710.

    Article  PubMed  CAS  Google Scholar 

  • Platts-Mills, T. A. E., and Ishizaka, K., 1975, IgG diphtheria antitoxin responses from human tonsil lymphocytes induced by anti-y-chain antibodies, J. Immunol. 114: 1605–1610.

    PubMed  CAS  Google Scholar 

  • Preud’homme, J. L., and Seligmann, M., 1972a, Immunoglobulins on the surface of lymphoid cells in Waldenström’s macroglobulinemia, J. Clin. Invest. 51: 701–705.

    Article  PubMed  Google Scholar 

  • Preud’homme, J. L., and Seligmann, M., 1972b, Surface bound immunoglobulins as a cell marker in human lymphoproliferative diseases Blood. 40: 777–794.

    PubMed  Google Scholar 

  • Raff, M. C., Sternberg, M., and Taylor, R. B., 1970, Immunoglobulin determinant on the surface of mouse lymphoid cells, Nature (London) 225: 553–554.

    Article  CAS  Google Scholar 

  • Raff, M. C., Feldman, M., and de Petris, S., 1973, Monospecificity of bone-marrow derived lymphocytes, J. Exp. Med. 137: 1024–1030.

    Article  PubMed  CAS  Google Scholar 

  • Raff, M. C., Owen, J. J. T., Cooper, M. D., Lawton, A. R., Megson, M., and Gathings, W., 1975, Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin induced immunoglobulin suppression in vitro: Possible implications for B cell tolerance to self, J. Exp. Med. 142: 1052–1064.

    Article  PubMed  CAS  Google Scholar 

  • Richards, F. F., Konigsberg, W. H., Rosenstein, R. W., and Varga, J. M., 1975, On the specificity of antibodies: Biochemical and biophysical evidence indicates the existence of polyfunction antibody combining regions, Science 187: 130–137.

    Article  PubMed  CAS  Google Scholar 

  • Rowe, D. S., Hug, K., Forni, L., and Pernis, B., 1973, Immunoglobulin D as a lymphocyte receptor, J. Exp. Med. 138: 965–972.

    Article  PubMed  CAS  Google Scholar 

  • Salsano, F., Froland, S. S., Natvig, J. B., and Michaelsen, T. E., 1974, Same idiotype of B lymphocyte membrane IgD and IgM: Evidence for monoclonality of chronic lymphocytic leukemia cells, Scand. J. Immunol. 3: 841–846.

    Article  PubMed  CAS  Google Scholar 

  • Schrader, J. W., 1975, Antagonism of B lymphocyte: Mitogenesis by anti-immunoglobulin antibody, J. Immunol. 115: 323–326.

    PubMed  CAS  Google Scholar 

  • Seligmann, M., Preud’homme, J. L., and Kourisky, F. M. (eds.), 1975, Membrane Receptors of Lymphocytes, North-Holland, Amsterdam and Oxford.

    Google Scholar 

  • Sell, S., and Gell, P. G. H., 1965, Studies on rabbit lymphocytes in vitro. I. Stimulation of blast transformation with an antiallotype serum, J. Exp. Med. 122: 423–439.

    Article  PubMed  CAS  Google Scholar 

  • Sidman, C. L., and Unanue, E. R., 1975, Receptor-mediated inactivation of early B lymphocytes, Nature (London) 257: 149–151.

    Article  CAS  Google Scholar 

  • Sidman, C. L., and Unanue, E. R., 1976, Control of B-lymphocyte function. I. Inactivation of mitogenesis by interactions with surface immunoglobulin and Fc-receptor molecules, J. Exp. Med. 144: 882–896.

    Article  PubMed  CAS  Google Scholar 

  • Skamen, E., and Ivanyi, J., 1969, Lymphocyte transformation by H-chain specific anti-immunoglobulin sera, Nature (London) 221: 681–682.

    Article  Google Scholar 

  • Stout, R. D., and Herzenberg, L. A., 1975, The Fc receptor of thymus-derived lymphocytes. I. Detection of a subpopulation of murine T lymphocytes bearing the Fc receptor, J. Exp. Med. 142: 611–621.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, R. B., Duffus, P. H., Raff, M. C., and de Petris, S., 1971, Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody, Nature (London) New Biol. 233: 225–229.

    CAS  Google Scholar 

  • Vitetta, E., and Uhr, J., 1972, Cell surface immunoglobulin. V. Release from murine splenic lymphocytes, J. Exp. Med. 135: 675–695.

    Article  Google Scholar 

  • Vitetta, E., Baur, S., and Uhr, J., 1971, Cell surface immunoglobulin. II. Isolation and characterization of immunoglobulin from mouse splenic lymphocytes, J. Exp. Med. 134: 242–264.

    Article  PubMed  CAS  Google Scholar 

  • Vitetta, E. S., Melcher, U., McWilliams, M., Phillips-Quagliata, J., Lamm, M., and Uhr, J., 1975, Cell surface Ig. IX. The appearance of an IgD-like molecule on murine lymphoid cells during ontogeny, J. Exp. Med. 141: 206–215.

    Article  PubMed  CAS  Google Scholar 

  • Warner, N. L., 1974, Membrane immunoglobulins and antigen receptors on B and T lymphocytes, Adv. Immunol. 19: 67–216.

    Article  PubMed  CAS  Google Scholar 

  • Weiner, H. L., Moorhead, J. W., and Claman, H. N., 1976a, Anti-immunoglobulin stimulation of murine lymphocytes. I. Age dependency of the proliferative response, J. Immunol. 116: 1656–1661.

    PubMed  CAS  Google Scholar 

  • Weiner, H. L., Moorhead, J. W., Yamaga, K., and Kubo, R. T., 1976b, Anti-immunoglobulin stimulation of murine lymphocytes. II. Identification of cell surface target molecules and requirements for cross-linkage, J. Immunol. 117: 1527–1531.

    PubMed  CAS  Google Scholar 

  • Winchester, R., Fu, S. M., and Kunkel, H. G., 1975, IgG on lymphocyte surfaces: Technical problems and the significance of a third cell population, J. Immunol. 114: 1210–1212.

    PubMed  CAS  Google Scholar 

  • Wolf, B., Janeway, C. A., Jr., Coombs, R. R. A., Carry D., Gell, P. G. H., and Kelus, A. S., 1971, Immunologlobulin determinants on the lymphocytes of normal rabbits. III. As4 and As6 determinants on individual lymphocytes and the concept of allelic exclusion, Immunology 20: 931–944.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Microbiology and Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA

    Benvenuto Pernis

Authors
  1. Benvenuto Pernis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sloan-Kettering Institute for Cancer Research, Rye, New York, USA

    Gary W. Litman Ph. D.

  2. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Robert A. Good Ph. D., M. D.

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Plenum Publishing Corporation

About this chapter

Cite this chapter

Pernis, B. (1978). Lymphocyte Membrane Immunoglobulins: An Overview. In: Litman, G.W., Good, R.A. (eds) Immunoglobulins. Comprehensive Immunology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0805-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-0805-8_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0807-2

  • Online ISBN: 978-1-4684-0805-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation