• Ananda Shiva Prasad
Part of the Topics in Hematology book series (TOHE)


In 1931, manganese was shown to be essential for growth and reproduction in rats and mice (Kemmerer et al., 1931; Orent and McCollum, 1931). Wilgus et al. (1936) later demonstrated that manganese prevented a skeletal abnormality in chickens, called “perosis.” Even though manganese has been shown to be essential for many species of animals, as yet there are no well-defined occurrences of manganese deficiency in man (Leach, 1976).


Pyruvate Carboxylase Farnesyl Pyrophosphate Glycosyl Transferase Postural Defect Manganese Toxicity 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Ananda Shiva Prasad
    • 1
    • 2
  1. 1.School of Medicine and Department of Medicine, Harper-Grace HospitalWayne State UniversityDetroitUSA
  2. 2.Veterans Administration HospitalAllen ParkUSA

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