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Magnesium

  • Ananda Shiva Prasad
Part of the Topics in Hematology book series (TOHE)

Abstract

Magnesium is one of the most plentiful elements on earth, and it is the fourth most abundant cation in the vertebrate. Magnesium is associated with many different biological processes, indicating that it may have a fundamental role in life (Aikawa, 1971, 1976).

Keywords

Celiac Disease Serum Magnesium Magnesium Deficiency Alcohol Withdrawal Syndrome Delirium Tremens 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Agna, J. W., and Goldsmith, R. E. 1958. Primary hyperparathyroidism associated with hypomagnesemia. N. Engl. J. Med. 258, 222–225.CrossRefGoogle Scholar
  2. Aikawa, J. K. 1959a. Gastrointestinal absorption of Mg28 in rabbits. Proc. Soc. Exp. Biol. Med. 100, 293–295.PubMedGoogle Scholar
  3. Aikawa, J. K. 1959b. The role of magnesium in biologic processes: A review of recent developments. In: Electrolytes and Cardiovascular Diseases (E. Bajusz, ed.). Karger, Basel, pp. 9–27.Google Scholar
  4. Aikawa, J. K., 1971. The Relationship of Magnesium to Disease in Domestic Animals and in Humans. Charles C. Thomas, Springfield, Illinois, pp. 1–145.Google Scholar
  5. Aikawa, J. K. 1976. Biochemistry and physiology of magnesium. In: Trace Elements in Humans: Health and Disease, Vol. II (A. S. Prasad, ed.). Academic Press, New York, pp. 47–78.Google Scholar
  6. Aikawa, J. K., Rhoades, E. L., and Gordon, G. S. 1958. Urinary and fecal excretion of orally administered Mg28. Proc. Soc. Exp. Biol. Med. 98, 29–31.PubMedGoogle Scholar
  7. Aikawa, J. K., Rhoades, E. L., Harms, D. R., and Reardon, J. Z. 1959. Magnesium metabolism in rabbits using Mg28 as a tracer. Amer. J. Physiol. 197, 99–101.PubMedGoogle Scholar
  8. Aikawa, J. K., Gordon, G. S., and Rhoades, E. L. 1960. Magnesium metabolism in human beings: Studies with Mg28. J. Appl. Physiol. 15, 503–507.PubMedGoogle Scholar
  9. Alcock, N. W., and Maclntyre, I. 1962. Inter-relation of calcium and magnesium absorption. Clin. Sci. 22, 185–193.PubMedGoogle Scholar
  10. Aldrete, J. A., Barnes, D. R., and Aikawa, J. K. 1968. Does magnesium produce anesthesia? Anesth. Analg. (Cleveland) 47, 428–433.Google Scholar
  11. Alexander, C. 1966. Idiopathic heart disease: Electron microscopic examination of myocardial biopsy in alcoholic heart disease. Amer. J. Med. 41, 229–234.PubMedCrossRefGoogle Scholar
  12. Alfredson, K. S., and Walser, M. 1970. Is magnesium secreted by the rat renal tubule? Nephron 7, 241–247.PubMedCrossRefGoogle Scholar
  13. Altenähr, E., and Leonhardt, F. 1972. Suppression of parathyroid gland activity by magnesium: Morphometric ultrastructural study. Virchows Arch. A: 355, 297–308.CrossRefGoogle Scholar
  14. Anast, C. S., Mohs, J. M., Kaplan, S. L., and Burns, T. W. 1972. Evidence for parathyroid failure in magnesium deficiency. Science 177 606–608.PubMedCrossRefGoogle Scholar
  15. Averill, C. M., and Heaton, F. W. 1966. The renal handling of magnesium. Clin. Sci. 31, 353–360.PubMedGoogle Scholar
  16. Avioli, L. V., and Berman, M. 1966. Mg28 kinetics in man. J. Appl. Physiol. 21, 1688–1694.PubMedGoogle Scholar
  17. Bajpai, P. C, Sugden, D., Stern, L., and Denton, R. L. 1967. Serum ionic magnesium in exchange transfusion. J. Pediatr. 70, 193–199.PubMedCrossRefGoogle Scholar
  18. Balint, J. A., and Hirschowitz, B. I. 1961. Hypomagnesemia with tetany in nontropical sprue. N. Engl. J. Med. 265, 631–633.PubMedCrossRefGoogle Scholar
  19. Barnes, B. A. 1969. Magnesium conservation: A study of surgical patients. Ann. N. Y. Acad. Sci. 162, 786–802.PubMedCrossRefGoogle Scholar
  20. Barnes, B. A., Cope, O., and Harrison, T. 1958. Magnesium conservation in the human being on low magnesium diet. J. Clin. Invest. 37, 430–440.PubMedCrossRefGoogle Scholar
  21. Barnes, B. A., Cope, O., and Gordon, E. B. 1960. Magnesium requirements and deficits: An evaluation of two surgical patients. Ann. Surg. 152, 518–533.PubMedGoogle Scholar
  22. Baron, D. N. 1960. Magnesium deficiency after gastrointestinal surgery and loss of excretions. Brit. J. Surg. 48, 344–346.PubMedCrossRefGoogle Scholar
  23. Baron, D. N., and Ahmet, S. A. 1969. Intracellular concentrations of water and of the principal electrolytes determined by analysis of isolated human leucocytes. Clin. Sci. 37, 205–219.PubMedGoogle Scholar
  24. Belsche, J. D., Buckley, J. J., and Van Bergen, F. H. 1964. Use of calcium and magnesium cations as spinal anesthetics. Univ. Minn. Med. Bull. 35, 369–370.Google Scholar
  25. Berglund, F., and Forster, R. P. 1958. Renal tubular transport of inorganic divalent ions by the aglomerular teleost, Lophius americanus. J. Gen. Physiol. 31, 429–440.CrossRefGoogle Scholar
  26. Black, E. H., Montgomery, R. D., and Ward, E. E. 1962. Neurological manifestations in infantile gastroenteritis and malnutrition. Arch. Dis. Child. 37, 106–109.CrossRefGoogle Scholar
  27. Booth, C. C, Babouris, N., Hanna, S., and MacIntyre, I. 1963. Incidence of hypomagnesemia in intestinal malabsorption. Brit. Med. J. 2, 141–144.PubMedCrossRefGoogle Scholar
  28. Breibart, S., Lee, J. S., McCoord, A., and Forbes, G. 1960. Relation of age to radiomagnesium in bone. Proc. Soc. Exp. Biol. Med. 105, 361–363.Google Scholar
  29. Broughton, A., Anderson, I. R. M., and Bowden, C. H. 1968. Magnesium deficiency syndrome in burns. Lancet 2, 1156–1158.PubMedCrossRefGoogle Scholar
  30. Buckle, R. M., Care, A. D., Cooper, C. W., and Gitelman, H. J. 1968. The influence of plasma magnesium concentration on parathyroid hormone secretion. J. Endocrinol. 42, 529–534.PubMedCrossRefGoogle Scholar
  31. Bunce, G. E., Reeves, P. G., Oba, T. S., and Säuberlich, H. E. 1963. Influence of the dietary protein level on the magnesium requirement. J. Nutr. 79, 2220–2226.Google Scholar
  32. Butler, A. M., Talbot, N. B., Burnett, C. H., Stanbury, J. B., and MacLachlan, E. A. 1947. Metabolic studies in diabetic coma. Trans. Assoc. Amer. Physicians 60, 102–109.Google Scholar
  33. Caddell, J. L. 1969. Magnesium deficiency in protein-calorie malnutrition: A follow-up study. Ann. N.Y. Acad. Sci. 162, 874–890.PubMedCrossRefGoogle Scholar
  34. Caddell, J. L., and Olson, R. E. 1973. An evaluation of the electrolyte status of malnourished Thai children. J. Pediatr. 83, 124–128.PubMedCrossRefGoogle Scholar
  35. Caddell, J. L., Suskind, R., Sillup, H., and Oison, R. E. 1973. Parenteral magnesium load evaluation of malnourished Thai children. J. Pediatr. 83, 129–135.PubMedCrossRefGoogle Scholar
  36. Case, G. S., Sinnott, M. L., and Tenu, J. P. 1973. The role of magnesium ions in betagalactosidase hydrolyses: Studies on charge and shape of the beta-galactopyranosyl binding site. Biochem. J. 133, 99–104.PubMedGoogle Scholar
  37. Chadda, H. D., Lichstein, E., and Gupta, P. 1973. Hypomagnesemia and refractory cardiac arrhythmias in a nondigitalized patient. Amer. J. Cardiol. 31, 98–100.PubMedCrossRefGoogle Scholar
  38. Chesley, L. C, and Tepper, I. 1958. Some effects of magnesium loading upon renal excretion of magnesium and certain other electrolytes. J. Clin. Invest. 37, 1362–1372.PubMedCrossRefGoogle Scholar
  39. Chutkow, J. G. 1964. Sites of magnesium absorption and excretion in the intestinal tract of the rat. J. Lab. Clin. Med. 63, 71–79.PubMedGoogle Scholar
  40. Chutkow, J. G. 1974. Clincal-chemical correlations in the encephalopathy of magnesium deficiency. Mayo Clin. Proc. 49, 244–247.PubMedGoogle Scholar
  41. Chutkow, J. G., and Myers, S. B. 1968. Chemical changes in cerebrospinal fluid and brain in magnesium deficiency. Neurology 18, 963–974.PubMedCrossRefGoogle Scholar
  42. Clarke, P. C. N., and Carré, I. J. 1967. Hypocalcémic, hypomagnesemic convulsions. J. Pediatr. 70, 806–809.PubMedCrossRefGoogle Scholar
  43. Clement, R. M., Sturm, J., and Daune, M. D. 1973. Interaction of metallic cations with DNA. VI. Specific binding of Mg++ and Mn++. Biopolymers 12, 405–421.CrossRefGoogle Scholar
  44. Cohen, M. I., McNamera, H., and Finberg, L. 1970. Serum magnesium in children with cirrhosis. J. Pediatr. 76, 453–455.PubMedCrossRefGoogle Scholar
  45. Colby, R. W., and Frye, C. M. 1951. Effect of feeding high levels of protein and calcium in rat rations on magnesium deficiency syndrome. Amer. J. Physiol. 166, 408–412.PubMedGoogle Scholar
  46. Consolazio, C. F., Matoush, L. O., Nelson, R. A., Harding, R. S., and Canham, J. E. 1963. Excretion of sodium, potassium, magnesium, and iron in human sweat and the relation of each to balance and requirements. J. Nutr. 79, 407–415.PubMedGoogle Scholar
  47. Coussons, H. 1969. Magnesium metabolism in infants and children. Postgrad. Med. 46, 135–139.PubMedGoogle Scholar
  48. Dimich, A., Rizek, J. E., Wallach, S., and Silver, W. 1966. Magnesium transport in patients with thyroid disease. J. Clin. Endocrinol. Metab. 26, 1081–1092.PubMedCrossRefGoogle Scholar
  49. Dunn, M. J., and Walser, M. 1966. Magnesium depletion in normal man. Metab. Clin. Exp. 15, 884–895.PubMedCrossRefGoogle Scholar
  50. Edmondson, H. A., Berne, C. J., Homann, R. E., and Wertman, M. 1952. Calcium, potassium, magnesium and amylase disturbances in acute pancreatitis. Amer. J. Med. 12, 34–42.PubMedCrossRefGoogle Scholar
  51. Eliel, L. P., Smith, W. O., Chanes, R., and Howrylko, J. 1969. Magnesium metabolism in hyperparathyroidism and osteolytic disease. Ann. N. Y. Acad. Sci. 162, 810–830.PubMedCrossRefGoogle Scholar
  52. Engbaek, L. 1952. Pharmacological actions of magnesium ions with particular reference to neuromuscular and cardiovascular system. Pharmacol. Rev. 4, 396–414.PubMedGoogle Scholar
  53. Estep, H., Shaw, W. A., Waltington, C, Höbe, R., Holland, W., and Tucker, S. G. 1969. Hypocalcemia due to hypomagnesemia and reversible parathyroid hormone unresponsiveness. J. Clin. Endocnnol. Metab. 29, 842–848.CrossRefGoogle Scholar
  54. Field, A. C. 1961. Magnesium in ruminant nutrition. III. Distribution of Mg28 in the gastrointestinal tract and tissues of sheep. Brit. J. Nutr. 15, 349–359.PubMedCrossRefGoogle Scholar
  55. Fishman, R. A., and Raskin, N. H. 1967. Experimental uremic encephalopathy: Permeability and electrolyte metabolism of brain and other tissues. Arch. Neurol. (Chicago) 17, 10–21.CrossRefGoogle Scholar
  56. Fitzgerald, M. G., and Fourman, P. 1956. An experimental study of magnesium deficiency in man. Clin. Sci. 15, 635–647.PubMedGoogle Scholar
  57. Fletcher, R. F., Henly, A. A., Sammons, H. G., and Squire, J. R. 1960. A case of magnesium deficiency following massive intestinal resection. Lancet 1, 522–525.PubMedCrossRefGoogle Scholar
  58. Flink, E. B. 1969. Therapy of magnesium deficiency. Ann. N. Y. Acad. Sci. 162, 901–905.PubMedCrossRefGoogle Scholar
  59. Flink, E. B. 1976. Magnesium deficiency and magnesium toxicity in man. In: Trace Elements in Human Health and Disease, Vol. 2 (A. S. Prasad, ed.). Academic Press, New York, pp. 1–21.Google Scholar
  60. Flink, E. B., Stutzman, F. L., Anderson, A. R., König, T., and Fraser, R. 1954. Magnesium deficiency after prolonged parenteral fluid administration and after chronic alcoholism, complicated by delirium tremens. J. Lab. Clin. Med. 43, 169–183.PubMedGoogle Scholar
  61. Flink, E. B., Stutzman, F. L., Anderson, A. R., König, T., and Fraser, R. 1954. Magnesium deficiency after prolonged parenteral fluid administration and after chronic alcoholism, complicated by delirium tremens. J. Clin. Invest. 32, 568, 1953 (abstract).Google Scholar
  62. Flink, E. B., McCollister, R., Prasad, A. S., Melby, J. D., and Doe, R. P. 1957. Evidences for clinical magnesium deficiency. Ann. Intern. Med. 47, 956–968.PubMedCrossRefGoogle Scholar
  63. Flink, E. B., Flink, P. F., Shane, S. R., Jones, J. E., and Steffes, P. E. 1973. Magnesium and free fatty acids in alcoholism. Clin. Res. 21, 884.Google Scholar
  64. Flowers, C. E., Jr., Easterling, W. E., Jr., White, F. D., Jung, J. M., and Fox, J. T., Jr. 1962. Magnesium sulfate in toxemia of pregnancy. Obstet. Gynecol. 19, 315–327.PubMedGoogle Scholar
  65. Forster, R. P., and Berglund, F. 1956. Osmotic diuresis and its effect on total electrolyte distribution in plasma and urine of the aglomerular teleost, Lophius americanus. J. Gen. Physiol. 39, 349–359.PubMedCrossRefGoogle Scholar
  66. Fraser, R., and Flink, E. B. 1951. Magnesium, potassium, phosphorus, chloride and vitamin deficiency as a result of prolonged use of parenteral fluids. J. Lab. Clin. Med. 38, 809.Google Scholar
  67. Friedman, M., Hatcher, G., and Watson, L. 1967. Primary hypomagnesemia with secondary hypocalcemia in an infant. Lancet 1, 703–705.PubMedCrossRefGoogle Scholar
  68. Gerlach, K., Morowitz, D. A., and Kirsner, J. B. 1970. Symptomatic hypomagnesemia complicating regional enteritis. Gastroenterology 59, 567–574.PubMedGoogle Scholar
  69. Gill, J. R., Jr., Bell, N. H., and Bartter, F. C. 1967. Effect of parathyroid extract on magnesium excretion in man. J. Appl. Physiol. 22, 136–138.PubMedGoogle Scholar
  70. Ginn, H. E., Smith, W. O., Hammarsten, J. F., and Snyder, D. 1959. Renal tubular secretion of magnesium in dogs. Proc. Soc. Exp. Biol. Med. 101, 691–692.PubMedGoogle Scholar
  71. Gitelman, H. J., Kukolj, S., and Welt, L. G. 1968a. The influence of the parathyroid glands on the hypercalcemia of experimental magnesium depletion in the rat. J. Clin. Invest. 47, 118–126.PubMedCrossRefGoogle Scholar
  72. Gitelman, H. J., Kukolj, S., and Welt, L. G. 1968b. Inhibition of parathyroid gland activity by hypermagnesemia. Amer. J. Physiol. 215, 483–485.PubMedGoogle Scholar
  73. Gitelman, H. J., Graham, J. B., and Welt, L. G. 1969. A familial disorder characterized by hypokalemia and hypomagnesemia. N.Y. Acad. Sci. Annu. 162, (Art. 2), 856–864.CrossRefGoogle Scholar
  74. Glickman, L. S., Schenker, V., Gronick, S., Green, A., and Schenker, A. 1962. Cerebrospinal fluid cation levels in delirium tremens with special reference to magnesium. J. Nerv. Ment. Dis. 134, 410–414.PubMedCrossRefGoogle Scholar
  75. Goldman, L. A., Fossan, D. D. V., and Baird, E. E. 1962. Magnesium deficiency in celiac disease. Pediatrics 29, 948–952.PubMedGoogle Scholar
  76. Goodman, L. S., and Gilman, A. (eds.). 1970. Pharmacological Basis of Therapeutics, 4th ed. MacMillan, New York, pp. 811–814.Google Scholar
  77. Gordon, G. S. 1963. A direct action of parathyroid hormone on dead bone in vitro. Acta Endocrol. (Copenhagen) 44, 481–489.Google Scholar
  78. Graham, L. A., Caesar, J. J., and Burgen, A. S. V. 1960. Gastrointestinal absorption and excretion of Mg28 in man. Metab. Clin. Exp. 9, 646–659.PubMedGoogle Scholar
  79. Greenwald, J. H., Dubin, A., and Cardon, L. 1963. Hypomagnesemic tetany due to excessive lactation. Amer. J. Med. 35, 854–860.PubMedCrossRefGoogle Scholar
  80. Haijamae, H., and MacDowall, I. G. 1972. Distribution of divalent cations at the cellular level during primary hypomagnesemia in infancy. Acta Paediatr. Scand. 61, 591–596.PubMedCrossRefGoogle Scholar
  81. Hammarsten, J. F., and Smith, W. O. 1957. Symptomatic magnesium deficiency in man. TV. Engl. J. Med. 256, 897–899.CrossRefGoogle Scholar
  82. Hanna, S., Maclntyre, I., Harrison, M., and Fraser, R. 1960. The syndrome of magnesium deficiency in man. Lancet 2, 172–175.PubMedCrossRefGoogle Scholar
  83. Hänze, S., and Seyberth, H. 1967. Untersuchungen zur Wirkung der Diuretica Furosemide, Ethacrynsäure and Triamiteren auf die rénale Magnesium und Calcium-ausscheidung. Klin. Wochenschr. 45, 313–314.PubMedCrossRefGoogle Scholar
  84. Harman, M. 1956. Parathyroid adenoma in a child. Amer. J. Dis. Child. 91, 313–325.Google Scholar
  85. Heaton, F. W. 1965. The parathyroid and magnesium metabolism in the rat. Clin. Sci. 28, 543–553.PubMedGoogle Scholar
  86. Heaton, F. W. 1969. The kidney and magnesium homeostasis. Ann. N. Y. Acad. Sci. 162, 775–785.PubMedCrossRefGoogle Scholar
  87. Heaton, F. W., and Fourman, P. 1965. Magnesium deficiency and hypocalcemia in intestinal malabsorption. Lancet 2, 50–52.CrossRefGoogle Scholar
  88. Heaton, F. W., and Pyrah, L. N. 1963. Magnesium metabolism in patients with parathyroid disorders. Clin. Sci. 25, 475–485.PubMedGoogle Scholar
  89. Heaton, F. W., Pyrah, L. N., Beresford, C. C, Bryson, R. W., and Martin, D. F. 1962. Hypomagnesemia in chronic alcoholism. Lancet 2, 802–805.CrossRefGoogle Scholar
  90. Hendrix, J. Z., Alcock, N. W., and Archibald, R. M. 1963. Competition between calcium, strontium, and magnesium for absorption in the isolated rat intestine. Clin. Chem. 9, 734–744.Google Scholar
  91. Hirschfelder, A. D., and Haury, V. G. 1934. Clinical manifestations of high and low plasma magnesium: Dangers of epsom salt purgation in nephritis. J. Amer. Med. Assoc. 102, 1138–1141.CrossRefGoogle Scholar
  92. Holmes, A. M., Hesling, C. M., and Wilson, T. M. 1969. Drug induced secondary aldosteronism in patients with pulmonary tuberculosis. Q. J. Med. 39, 299–315.Google Scholar
  93. Hughes, M. N. 1972. The Inorganic Chemistry of Biological Processes. Wiley, New York, 304 pp.Google Scholar
  94. Jones, J. E., Albrink, M. J., Davidson, P. D., and Flink, E. B. 1966a. Fasting and refeeding of various suboptimal isocaloric diets. Amer. J. Clin. Nutr. 19, 320–328.PubMedGoogle Scholar
  95. Jones, J. E., Desper, P. C, Shane, S. R., and Flink, E. B. 1966b. Magnesium metabolism in hyperthyroidism and hypothyroidism. J. Clin. Invest. 45, 891–900.PubMedCrossRefGoogle Scholar
  96. Jones, J. E., Manalo, R., and Flink, E. B. 1967. Magnesium requirements in adults. Amer. J. Clin. Nutr. 20, 632–635.PubMedGoogle Scholar
  97. Jones, J. E., Shane, S. R., Jacobs, W. H., and Flink, E. B. 1969. Magnesium balance studies in chronic alcoholism. Ann. N.Y. Acad. Sci. 162, 934–946.PubMedCrossRefGoogle Scholar
  98. Kalbfleisch, J. M., Lindeman, R. D., Ginn, H. E., and Smith, W. O. 1963. Effects of ethanol administration on urinary excretion of magnesium and other electrolytes in alcoholic and normal subjects. J. Clin. Invest. 42, 1471–1475.PubMedCrossRefGoogle Scholar
  99. Kallas, T. 1970. Symptomatic magnesium deficiency in urological patients. J. Urol. 104, 325–327.PubMedGoogle Scholar
  100. Keating, F. R., Jones, J. D., Elveback, L. R., and Randall, R. V. 1969. The relation of age and sex to distribution of values in healthy adults of serum calcium, inorganic phosphorus, magnesium alkaline phosphatase, total proteins, albumin, and blood urea. J. Lab. Clin. Med. 73, 825–834.PubMedGoogle Scholar
  101. Keipert, J. A. 1969. Primary hypomagnesemia with secondary hypocalcemia in an infant. Med. J. Aust. 2, 242–244.PubMedGoogle Scholar
  102. Kim, Y. W., Andrews, C. E., and Ruth, W. E. 1961. Serum magnesium and cardiac arrhythmias with special reference to digitalis intoxication. Amer. J. Med. Sci. 242, 87–92.PubMedCrossRefGoogle Scholar
  103. Lear, R. D., and Grøn, P. 1968. Magnesium in human saliva. Arch. Oral Biol. 13, 1311–1319.PubMedCrossRefGoogle Scholar
  104. Lengemann, F. W. 1959. The metabolism of magnesium and calcium by the rat. Arch. Biochem. 84, 278–285.PubMedCrossRefGoogle Scholar
  105. Lim, P. and Jacob, E. 1972. Magnesium status of alcoholic patients. Metab. Clin. Exp. 21, 1045–1051.PubMedCrossRefGoogle Scholar
  106. Lin, D. C, and Nobel, P. S. 1971. Control of photosynthesis by Mg2+. Arch. Biochem. Biophys. 145, 622–632.PubMedCrossRefGoogle Scholar
  107. Lipsitz, P. J., and English, I. C. 1967. Hypermagnesemia in the newborn infant. Pediatrics 40, 856–862.PubMedGoogle Scholar
  108. Littledike, E. T., and Arnaud, C. D. 1971. The influence of plasma magnesium concentrations on calcitonin secretion in the pig. Proc. Soc. Exp. Biol. Med. 136, 1000–1006.PubMedGoogle Scholar
  109. Loeb, H. S., Pietras, R. P., Gunnar, R. M., and Tobin, J. R. 1968. Paroxysmal ventricular fibrillation in two patients with hypomagnesemia. Circulation 37, 210–215.CrossRefGoogle Scholar
  110. MacIntyre, I. 1960. Discussion on magnesium metabolism in man and animals. Proc. R. Soc. Med. 53, 1037–1039.PubMedGoogle Scholar
  111. Maclntyre, I. 1967. Magnesium metabolism. Adv. Intern. Med. 13, 143–154.Google Scholar
  112. Maclntyre, I., Hanna, S., Booth, C. C, and Read, A. E. 1961. Intracellular magnesium deficiency in man. Clin. Sci. 20, 297–305.Google Scholar
  113. Maclntyre, I., Boss, S., and Troughton, V. A. 1963. Parathyroid hormone and magnesium homeostasis. Nature (London) 198, 1058–1060.CrossRefGoogle Scholar
  114. Mader, I. J., and Iseri, L. T. 1955. Spontaneous hypopotassemia, hypomagnesemia, alkalosis and tetany due to hypersécrétion of corticosterone-like mineralocorticoid. Amer. J. Med. 19, 976–988.PubMedCrossRefGoogle Scholar
  115. Martin, H. E., and Bauer, F. K. 1962. Magnesium28 studies in the cirrhotic and alcoholic. Proc. R. Soc. Med. 55, 912–914.PubMedGoogle Scholar
  116. Martin, H. E., and Wertman, M. 1947. Serum potassium, magnesium and calcium levels in diabetic acidosis. J. Clin. Invest. 26, 217–228.PubMedCrossRefGoogle Scholar
  117. Martin, H. E., Mehl, J., and Wertman, M. 1952. Clinical studies of magnesium metabolism. Med. Clin. North Amer. 36, 1157–1171.Google Scholar
  118. Martin, H. E., McCuskey, C, Jr., and Tupikova, N. 1959. Electrolyte disturbance in acute alcoholism with particular reference to magnesium. Amer. J. Clin. Nutr. 7, 191–196.PubMedGoogle Scholar
  119. Martindale, L., and Heaton, F. W. 1965. The relation between skeletal and extracellular fluid in vitro. Biochem. J. 97, 440–443.PubMedGoogle Scholar
  120. Massry, S. G., Coburn, J. W., and Kleeman, C. R. 1969. Renal handling of magnesium in the dog. Amer. J. Physiol. 216, 1460–1467.PubMedGoogle Scholar
  121. McAleese, E. M., Bell, M. C, and Forbes, R. M. 1960. Mg28 studies in lambs. J. Nutr. 74, 505–514.Google Scholar
  122. McCollister, R., Prasad, A. S., Doe, R. P., and Flink, E. B. 1958. Normal renal magnesium clearance and the effect of water loading, chlorothiazide and ethanol on magnesium excretion. J. Lab. Clin. Med. 52, 928.Google Scholar
  123. McCollister, R. J., Flink, E. B., and Doe, R. P. 1960. Magnesium balance studies in chronic alcoholism. J. Lab. Clin. Med. 55, 98–104.Google Scholar
  124. McCollister, R. J., Flink, E. B., and Lewis, M. 1963. Urinary excretion of magnesium in man following ingestion of ethanol. Amer. J. Clin. Nutr. 12, 415–420.Google Scholar
  125. Mellinghoff, K. 1949. Magnesium Stoffwechselstörungen bei Inanition. Dtsch. Arch. Klin. Med. 195, 475.Google Scholar
  126. Mendelson, J., Wexler, D., Kubzansky, P., Leiderman, H., and Solomon, P. 1959. Serum magnesium in delirium tremens and alcoholic hallucinosis. J. Nerv. Ment. Dis. 128, 352–357.PubMedGoogle Scholar
  127. Mendelson, J. H., Barnes, B., Mayman, C, and Victor, M. 1965. The determination of exchangeable magnesium in alcoholic patients. Metab. Clin. Exp. 14, 88–98.PubMedCrossRefGoogle Scholar
  128. Metcoff, J., Frenk, S., Antonowicz, I., Gordillo, G., and Lopez, E. 1960. Relations of intracellular ions to metabolite sequences in muscle in kwashiorkor. Pediatrics 26, 960–972.PubMedGoogle Scholar
  129. Miller, J. F. 1944. Tetany due to deficiency in magnesium: Its occurrence in a child of six years with associated osteochondrosis of capital epiphysis of femurs. Amer. J. Dis. Child. 67, 117–119.Google Scholar
  130. Milner, G., and Johnson, J. 1965. Hypomagnesemia and delirium tremens: Report of case with fatal outcome. Amer. J. Psychiatry. 122, 701–702.Google Scholar
  131. Monif, G. R. G., and Savory, J. 1972. Iatrogenic maternal hypocalcemia following magnesium sulfate therapy. J. Amer. Med. Assoc. 219, 1469–1470.CrossRefGoogle Scholar
  132. Montgomery, R. D. 1960. Magnesium deficiency and tetany in kwashiorkor. Lancet 2, 74–76.PubMedCrossRefGoogle Scholar
  133. Montgomery, R. D. 1961. Magnesium balance studies in marasmic kwashiorkor. J. Pediatr. 59, 119–123.PubMedCrossRefGoogle Scholar
  134. Muldowney, F. P., McKenna, T. J., Kyle, L. H., Freaney, R., and Swan, M. 1970. Parathormone-like effect of magnesium replenishment in steatorrhea. N. Engl. J. Med. 281, 61–68.CrossRefGoogle Scholar
  135. Murdaugh, H. V., and Robinson, R. R. 1960. Magnesium excretion in the dog studied by stopflow analysis. Amer. J. Physiol. 198, 571–574.PubMedGoogle Scholar
  136. Nabarro, J. D. N., Spencer, A. G. D., and Stowers, J. M. 1952. Metabolic studies in severe diabetic ketosis. Q. J. Med. 21, 225–248.PubMedGoogle Scholar
  137. Nielsen, J. 1963. Magnesium metabolism in an acute alcoholic. Dan. Med. Bull. 10, 225–233.PubMedGoogle Scholar
  138. Nielsen, J. A., and Thaysen, E. H. 1971. Acute and chronic magnesium deficiency following extensive small gut resection. Scand. J. Gastroenterol. 6, 663–666.PubMedCrossRefGoogle Scholar
  139. Nordia, S., Donath, F., Macagno, R., and Gatti, T. 1971. Chronic hypomagnesemia with magnesium dependent hypocalcemia. Acta Paediatr. Scand. 60, 441–448.CrossRefGoogle Scholar
  140. Opie, L. H., Hurst, B. J., and Finlay, J. M. 1964. Massive small bowel resection with malabsorption and negative magnesium balance. Gastroenterology 47, 415–420.PubMedGoogle Scholar
  141. Paunier, L., Radde, I. C, Kooh, S. W., and Fraser, D. 1965. Primary hypomagnesemia with secondary hypocalcemia. J. Pediatr. 67, 945 (abstract).Google Scholar
  142. Paunier, L., Radde, I. C, Kooh, S. W., Conen, P. E., and Fraser, D. 1968. Primary hypomagnesemia with secondary hypocalcemia in an infant. Pediatrics 41, 385–402.PubMedGoogle Scholar
  143. Potts, J. T., Jr., and Roberst, B. 1958. Clinical significance of magnesium deficiency and its relation to parathyroid disease. Amer. J. Med. Sci. 235, 206–219.PubMedCrossRefGoogle Scholar
  144. Prasad, A. S., Flink, E. B., and Zinnemann, H. H. 1959. The base binding property of serum proteins with respect to magnesium. J. Lab. Clin. Med. 54, 357–364.PubMedGoogle Scholar
  145. Prasad, A. S., Flink, E. B., and McCollister, R. 1961. Ultrafiltration studies on serum magnesium in normal and diseased states. J. Lab. Clin. Med. 58, 531–541.PubMedGoogle Scholar
  146. Randall, R. E., Jr. 1969. Magnesium metabolism in chronic renal disease. Ann. N. Y. Acad. Sci. 162, 831–842.PubMedCrossRefGoogle Scholar
  147. Randall, R. E., Rossmeisl, E. C, and Bleifer, K. H. 1959. Magnesium depletion in man. Ann. Intern. Med. 50, 257–287.PubMedCrossRefGoogle Scholar
  148. Randall, R. E., Jr., Chen, M. D., Spray, C. C, and Rossmeisl, E. C. 1964. Hypermagnesemia in renal failure. Ann. Intern. Med. 61, 73–88.PubMedCrossRefGoogle Scholar
  149. Raynaud, C. 1962. Renal excretion of magnesium in the rabbit. Amer. J. Physiol. 203, 649–654.PubMedGoogle Scholar
  150. Ricketts, H. H., Denton, E. K., and Haywood, L. J. 1969. Unusual T-wave abnormality: Repolarization alternans associated with hypomagnesemia, acute alcoholism, and cardiomyopathy. J. Amer. Med. Assoc. 207, 365–366.CrossRefGoogle Scholar
  151. Rosen, E. A., Campbell, P. G., and Moosa, G. M. 1970. Hypomagnesemia and magnesium therapy in protein-calorie malnutrition. J. Pediatr. 77, 709–714.PubMedCrossRefGoogle Scholar
  152. Sallis, J. D., and DeLuca, H. F. 1966. Action of parathyroid hormone on mitochondria: Magnesium-and phosphate-independent respiration. J. Biol. Chem. 241, 1122–1127.PubMedGoogle Scholar
  153. Schroeder, H. A., Nason, A. P., and Tipton, I. H. 1969. Essential metals in man: Magnesium. J. Chronic Dis. 21, 815–841.PubMedCrossRefGoogle Scholar
  154. Seller, R. H., Cangiano, J., Kim, K. E., Mendelssohn, S., Brest, A. N., and Swartz, C. 1970. Digitalis toxicity and hypomagnesemia. Amer. Heart J. 79, 57–68.PubMedCrossRefGoogle Scholar
  155. Sherwood, L. M., Herrman, I., and Bassett, C. A. 1970. Parathyroid hormone secretion in vitro: Regulation by calcium and magnesium ions. Nature (London) 225, 1056–1057.CrossRefGoogle Scholar
  156. Shils, M. E. 1964. Experimental human magnesium depletion. I. Clinical observations and blood chemistry alternations. Amer. J. Clin. Nutr. 15, 133–143.PubMedGoogle Scholar
  157. Shils, M. E. 1969a. Experimental production of magnesium deficiency in man. Ann. N. Y. Acad. Sci. 162, 847–855.PubMedCrossRefGoogle Scholar
  158. Shils, M. E. 1969b. Experimental human magnesium depletion. Medicine (Baltimore) 48, 61–85.CrossRefGoogle Scholar
  159. Silver, L., Robertson, J. S., and Dahl, L. K. 1960. Magnesium turnover in the human studied with Mg28. J. Clin. Invest. 39, 420–425.PubMedCrossRefGoogle Scholar
  160. Skyberg, D., Strømme, J. H., Nesbakken, R., and Harnas, K. 1967. Congenital primary hypomagnesemia, an inborn error of metabolism. Acta Paediatr. Scand. Suppl. 177, 26–27.CrossRefGoogle Scholar
  161. Smith, R. H., and McAllan, A. B. 1966. Binding of magnesium and calcium in the contents of the small intestine of the calf. Brit. J. Nutr. 20, 703–718.PubMedCrossRefGoogle Scholar
  162. Smith, W. O. 1963. Magnesium deficiency in the surgical patient. Amer. J. Cardiol. 12, 667–670.PubMedCrossRefGoogle Scholar
  163. Smith, W. O., and Hammarsten, J. F. 1959. Intracellular magnesium in delirium tremens and uremia. Amer. J. Med. Sci. 237, 413–417.PubMedCrossRefGoogle Scholar
  164. Sokal, M. M., Koenigsberger, M. R., Rose, J. S., Berdon, W. E., and Santulli, T. V. 1972. Neonatal hypermagnesemia and the meconium-plug syndrome. N. Engl. J. Med. 286, 823–825.PubMedCrossRefGoogle Scholar
  165. Somjen, G. G., Hilmy, M., and Stephen, C. R. 1966. Failure to anesthetize human subjects by intravenous administration of magnesium sulfate. J. Pharmacol. Exp. Ther. 154, 652–659.PubMedGoogle Scholar
  166. Stony, J. E., and Rook, J. A. F. 1962. The magnesium nutrition of the dairy cow in relation to the development of hypomagnesaemia in the grazing animal. J. Sci. Food Agric. 13, 621–627.CrossRefGoogle Scholar
  167. Strømme, J. H., Nesbakken, R., Norman, T., Skjrten, F., Skyberg, D., and Johannessen, B. 1969. Familial hypomagnesemia: Biochemical, histological and hereditary aspects studied in two brothers. Acta Paediatr. Scand. 58, 433–444.PubMedCrossRefGoogle Scholar
  168. Suh, S. M., Trashjian, A. H., Jr., Matsuo, N., Parkinson, D. K., and Fraser, D. 1973. Pathogenesis of hypocalcemia in primary hypomagnesemia: Normal end-organ responsiveness to parathyroid hormone, impaired parathyroid gland function. J. Clin. Invest. 52, 153–160.PubMedCrossRefGoogle Scholar
  169. Sullivan, J. F., Parker, M., and Carsons, S. B. 1968. Tissue cobalt in beer drinkers myocardiopathy. J. Lab. Clin. Med. 71, 893–911.PubMedGoogle Scholar
  170. Szelényi, I. 1973. Magnesium and its significance in cardiovascular and gastro-intestinal disorders. World Rev. Nutr. Diet 17, 189–224.PubMedGoogle Scholar
  171. Tapley, D. F. 1955. Magnesium balance in myxedematous patients treated with triiodothyronine. Bull. Johns Hopkins Hosp. 96, 274–278.PubMedGoogle Scholar
  172. Thoren, L. 1963. Magnesium deficiency in gastrointestinal fluid loss. Acta Chir. Scand. Suppl. 306, 1–65.Google Scholar
  173. Tsang, R. C. 1972. Neonatal magnesium disturbances. Amer. J. Dis. Child. 124, 282–293.PubMedGoogle Scholar
  174. Wacker, W. E. C, and Parisi, A. F. 1968. Magnesium metabolism. N. Engl. J. Med. 278, 658–662, 712-717, 772-776.PubMedCrossRefGoogle Scholar
  175. Wacker, W. E. C, and Vallée, B. L. 1958. Magnesium metabolism. N. Engl. J. Med. 259, 431–438.PubMedCrossRefGoogle Scholar
  176. Wallach, S., Rizek, J. E., Dimich, A., Prasad, N., and Siler, W. 1966. Magnesium transport in normal and uremic patients. J. Clin. Endocrinol. Metab. 26, 1069–1080.PubMedCrossRefGoogle Scholar
  177. Widdowson, E. M., McCance, R. A., and Spray, C. M. 1951. The chemical composition of the human body. Clin. Sci. 10, 113–125.Google Scholar
  178. Willick, G. E., and Kay, C. M. 1971. Magnesium-induced conformational change in transfer ribonucleic acid as measured by circular dichroism. Biochemistry 10, 2216–2222.PubMedCrossRefGoogle Scholar
  179. Wilson, A. A. 1960. Magnesium homeostasis and hypomagnesaemia in ruminants. Vet. Rev. 6, 39–52.Google Scholar
  180. Wolfe, S., and Victor, N. 1969. The relationship of hypomagnesemia to alcohol withdrawal symptoms. Ann. N. Y. Acad. Sci. 162, 973–984.PubMedCrossRefGoogle Scholar
  181. Wong, H. B., and Teh, Y. F. 1968. An association between serum magnesium and convulsions in infants and children. Lancet 2, 18–21.PubMedCrossRefGoogle Scholar
  182. Zitomer, R. S., and Flaks, J. G. 1972. Magnesium dependence and equilibrium of the Escherichia coli ribosomal subunit association. J. Mol. Biol. 71, 263–279.PubMedCrossRefGoogle Scholar
  183. Zumoff, B., Bernstein, E. H., Imarisio, J. J., and Hellman, L. 1958. Radioactive magnesium (Mg28) metabolism in man. Clin. Res. 6, 260.Google Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Ananda Shiva Prasad
    • 1
    • 2
  1. 1.School of Medicine and Department of Medicine, Harper-Grace HospitalWayne State UniversityDetroitUSA
  2. 2.Veterans Administration HospitalAllen ParkUSA

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