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Iron

  • Ananda Shiva Prasad
Part of the Topics in Hematology book series (TOHE)

Abstract

Iron was considered to be of celestial origin in ancient civilizations of the Eastern Mediterranean area. The “metal of heaven” was used in Egypt and Mesopotamia for therapeutic purposes. The oldest manuscript, the Ebers Papyrus, an Egyptian pharmacopea dating around 1500 B.C., describes two remedies that contained iron. The ancient Hindus (500 B.C.) also used iron therapeutically.

Keywords

Iron Deficiency Iron Absorption Iron Overload Serum Iron Iron Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aasa, R., Malmström, B. G., Saltman, P., and Vänngård, T. 1963. The specific binding of iron (III) and copper (II) to transferrin and conalbumin, Biochim. Biophys. Acta 75, 203–222.PubMedCrossRefGoogle Scholar
  2. Addison, G. M., Beamish, M. R., Hales, C. N., Hodgkins, M., Jacobs, A., and Llewellin, P. 1972. An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. J. Clin. Pathol. 25, 326–329.PubMedCrossRefGoogle Scholar
  3. Allen, D. W., and Jandl, J. H. 1960. Kinetics of intracellular iron in rabbit reticulocytes. Blood 15, 71–81.PubMedGoogle Scholar
  4. Allgood, J. W., and Brown, E. B. 1967. The relationship between duodenal mucosal iron concentration and iron absorption in human subjects. Scand. J. Haematol. 4, 217–229.PubMedCrossRefGoogle Scholar
  5. Alper, T., Savage, D. V., and Bothwell, T. H. 1951. Radioiron studies in a case of hemochromatosis. J. Lab. Clin. Med. 37, 665–675.PubMedGoogle Scholar
  6. Althausen, T. L., and Kerr, W. J. 1933. Hemochromatosis. II. A report of three cases with endocrine disturbances and notes on a previously reported case: Discussion of etiology. Endocrinology 17, 621–646.CrossRefGoogle Scholar
  7. Andersson, N. S. E. 1950. Experimental and clinical investigations into the effect of parenterally administered iron. Acta Med. Scand. 138 (Suppl. 241), 1–71.Google Scholar
  8. Aufderheide, A. C., Horns, H. L., and Goldish, R. J. 1953. Secondary hemochromatosis. I. Transfusion (exogenous) hemochromatosis. Blood 8, 824–836.PubMedGoogle Scholar
  9. Aisen, P., and Brown, E. B. 1977 The iron-binding function of transferrin in iron metabolism. Semin. Hematol. 14, 31–53.PubMedGoogle Scholar
  10. Bainton, D. F., and Finch, C. A. 1964. The diagnosis of iron deficiency anemia. Amer. J. Med. 37, 62–70.PubMedCrossRefGoogle Scholar
  11. Balcerzak, S. P., Westerman, M. P., Heinle, E. W., and Taylor, F. H. 1968. Measurement of iron stores using desferrioxamine. Ann. Inter. Med. 68, 518–525.CrossRefGoogle Scholar
  12. Balfour, W. M., Hahn, P. F., Bale, W. F., Pommerenke, W. T., and Whipple, G. H. 1942. Radioactive iron absorption in clinical conditions: Normal pregnancy, anemia, and hemochromatosis. J. Exp. Med. 76, 15–30.PubMedCrossRefGoogle Scholar
  13. Barkan, G. 1933. Die Unterscheidung des “leicht abspaltbaren” Bluteisens vom Hämoglobinesisen und vom anorganischem Eise. Hoppe-Seyler’s Z. Physiol. Chem. 221, 241–251.CrossRefGoogle Scholar
  14. Barry, M., Scheuer, P. J., Sherlock, S., Ross, C. F., and Williams, R. 1968. Hereditary spherocytosis with secondary haemochromatosis. Lancet 2, 481–485.PubMedCrossRefGoogle Scholar
  15. Barry, M., Cartei, G., and Sherlock, S. 1969. Differential ferrioxamine test in haemochromatosis and liver diseases. Gut 10, 697–704.PubMedCrossRefGoogle Scholar
  16. Barry. W. E., and Day, H. J. 1964. Refractory sideroblastic anemia: Clinical and hematologic study of ten cases. Ann. Intern. Med. 61, 1029–1044.PubMedCrossRefGoogle Scholar
  17. Bässler, R. 1961. Elektronenmikroskopische Befunde bei essentieller Lungenhämosiderose. Z. Pathol. 71, 259–282.Google Scholar
  18. Beal, V. A., Meyers, A. J., and McCammon, R. W. 1962. Iron intake, hemoglobin, and physical growth during the first two years of life. Pediatrics 30, 518–539.PubMedGoogle Scholar
  19. Becker, D., and Miller, M. 1960. Presence of diabetic glomerulosclerosis in patients with hemochromatosis. N. Engl. J. Med. 263, 367–373.PubMedCrossRefGoogle Scholar
  20. Beirne, G. J., Octaviano, G. N., Kopp, W. L., and Burns, R. O. 1968. Immunohistology of the lung in Goodpasture’s syndrome. Ann. Intern. Med. 69, 1207–1212.PubMedCrossRefGoogle Scholar
  21. Berlin, S. O., and Brante, G. 1962. Iron metabolism in porphyria and haemochromatosis (letter to the editor). Lancet 2, 729.CrossRefGoogle Scholar
  22. Bessis, M. C., and Breton-Gorius, J. 1957. Iron particles in normal erythroblasts and normal and pathological erthrocytes. J. Biophys. Biochem. Cytol. 3, 503–504.PubMedCrossRefGoogle Scholar
  23. Bessis, M. C., and Breton-Gorius, J. 1959. Ferritin and ferruginous micelles in normal erythroblasts and hypochromic hypersideremic anemias. Blood 14, 423–432.PubMedGoogle Scholar
  24. Bessis, M. C., and Breton-Gorius, J. 1962. Iron metabolism in the bone marrow as seen by electronmicroscopy. Blood 19, 635–663.PubMedGoogle Scholar
  25. Beutler, E. 1957. Iron enzymes in iron deficiency. Amer. J. Med. Sci. 234, 517–527.PubMedCrossRefGoogle Scholar
  26. Beutler, E. 1959a. Iron enzymes in iron deficiency. IV. Cytochrome oxidase in rat kidney and heart. Acta Haematol. 21, 371–377.PubMedCrossRefGoogle Scholar
  27. Beutler, E. 1959b. Iron enzymes in iron deficiency. VI. Aconitase activity and citrate metabolism. J. Clin. Invest. 38, 1605–1616.PubMedCrossRefGoogle Scholar
  28. Beutler, E. 1961. Hematology: Iron metabolism. Annu. Rev. Med. 12, 195–210.CrossRefGoogle Scholar
  29. Beutler, E., and Blaisdell, R. K. 1958. Iron enzymes in iron deficiency. III. Catalase in rat red cells and liver with some further observations in cytochrome c. J. Lab. Clin. Med. 52, 694–699.PubMedGoogle Scholar
  30. Beutler, E., and Blaisdell, R. K. 1960. Iron enzymes in iron deficiency. V. Succinic dehydrogenase in rat liver, kidney, and heart. Blood 15, 30–35.PubMedGoogle Scholar
  31. Beutler, E. Robson, M. J., and Buttenwiëser, E. 1958. A comparison of the plasma iron, iron-binding capacity, sternal marrow iron and other methods in the clinical evaluation of iron stores. Ann. Inter. Med. 48, 60–82.CrossRefGoogle Scholar
  32. Bezancon, F., de Gennes, L., Delarue, and Oumansky, 1932. Cirrhose pigmentaire avec infantilisme, insuffisance cardiaque et aplasies endocriniennes multiples. Bull. Soc. Med. Paris 48, 967–974.Google Scholar
  33. Bickers, N. J., Brown, C. L., and Sprague, C. C. 1962. Pyridoxine responsive anemia. Blood 19, 304–312.PubMedGoogle Scholar
  34. Biggs, J. C., and Davis, A. E. 1963. Relationship of diminished pancreatic secretion to haemochromatosis. Lancet 2, 814.PubMedCrossRefGoogle Scholar
  35. Biggs, J. C., and Davis, A. E. 1966. The exocrine pancreas and iron absorption. Aust. Ann. Med. 15, 36–39.PubMedGoogle Scholar
  36. Bishop, R. C., and Bethell, F. H. 1959. Hereditary hypochromic anemia with transfusion hemosiderosis treated with pyridoxine: Report of a case. N. Engl. J. Med. 261, 486–489.PubMedCrossRefGoogle Scholar
  37. Björkman, S. E. 1956. Chronic refractory anemia with sideroblastic bone marrow: A study of four cases. Blood 11, 250–259.PubMedGoogle Scholar
  38. Blomstrom, D. C., Knight, E., Jr., Phillips, W. D., and Weiler, J. F. 1964. The nature of iron in ferredoxin. Proc. Natl. Acad. Sci. U.S.A. 51, 1085–1092.PubMedCrossRefGoogle Scholar
  39. Bloom, V. R., Wayne, D. J., and Wrong, O. M. 1965. Lung purpura and nephritis (Goodpasture’s syndrome) complicated by the nephrotic syndrome. Ann. Intern. Med. 63, 752–759.PubMedCrossRefGoogle Scholar
  40. Blumer, G., and Nesbit, R. R. 1938. A case of hemochromatosis with degeneration of the heart muscle an death from congestive heart failure. N. Engl. J. Med. 218, 295–298.CrossRefGoogle Scholar
  41. Bolgert, M., Canivet, J., and Le Sourd, M. 1953. La porphyrie cutanée de l’adulte étude de neuf cas et description. Sem. Hop. Paris 29, 1587–1608.Google Scholar
  42. Bond, C. F. 1948. The nature of the anemia of pregnancy in the rat. Endocrinology 43, 180–191.PubMedCrossRefGoogle Scholar
  43. Bothwell, T. H., and Finch, C. A. 1962. In: Iron Metabolism. Little, Brown, Boston, pp. 1–440.Google Scholar
  44. Bothwell, T. H., van Doorn-Wittkampf, H. van W., Du Preez, M. L., and Alper, T. 1953. The absorption of iron: Radioiron studies in idiopathic hemochromatosis, malnutritional cytosiderosis, and transfusional hemosiderosis. J. Lab. Clin. Med. 41, 836–848.PubMedGoogle Scholar
  45. Bothwell, T. H., Ellis, B. C., van Doorn-Wittkampf, H. Van W., and Abrahams, O. L. 1955. Radioiron studies in hemochromatosis: The effects of repeated phlebotomies. J. Lab. Clin. Med. 45, 167–178.PubMedGoogle Scholar
  46. Bothwell, T. H., Hurtado, A. V., Donohue, D. M., and Finch, C. A. 1957. Erythrokinetics. IV. The plasma iron turnover as a measure of erythropoiesis. Blood 12, 409–427.PubMedGoogle Scholar
  47. Bothwell, T. H., Pirzio-Biroli, G., and Finch, C. A. 1958. Iron absorption. I. Factors influencing absorption. J. Lab. Clin. Med. 51, 24–36.PubMedGoogle Scholar
  48. Bothwell, T. H., Cohen, I., Abrahams, O. L., and Perold, S. M. 1959. A familial study in idiopathic hemochromatosis. Amer. J. Med. 27, 730–738.PubMedCrossRefGoogle Scholar
  49. Bottomley, S. S. 1977. Porphyrin and iron metabolism in sideroblastic anemia. Semin. Hematol. 14, 169–185.PubMedGoogle Scholar
  50. Boulet, P., Mirouze, J., Barjon, P., Mandin, A., Corbiére, J.-Cl., and Duntze, F. 1959. Porphyrie cutanée de l’adulte et diabéte sucré évolutif. Bull. Mem. Soc. Med. Hop. Paris 1, 653–656.Google Scholar
  51. Boulin, R., and Uhry, P. 1949. Le diabéte bronzé. Acta Gastroenterol. Belg. 12, 540–541.PubMedGoogle Scholar
  52. Bourne, M. S., Elves, M. W., and Israëls, M. C. G. 1965. Familial pyridoxine-responsive anaemia. Brit. J. Haematol. 11, 1–10.CrossRefGoogle Scholar
  53. Bousser, J., Gajdos, A., Gajdos-Török, M., Bilski-Pasquier, G., and Zittoun, R. 1967. Anémie sidéroblastique idiopathique acquise: Incorporation de la glycine-2-C-14 dans l’héme et la globine des érythroblastes médullaires in vitro. Nouv. Rev. Fr. Hematol. 7, 847–854.PubMedGoogle Scholar
  54. Braude, R., Chamberlain, A. G., Kotarbinski, M., and Mitchell, K. G. 1962. The metabolism of iron in piglets given labelled iron either orally or by injection. Brit. J. Nutr. 16, 427–449.PubMedCrossRefGoogle Scholar
  55. Britton, G. M. Stohlman, F., Jr., and Tanaka, Y. 1968. A primary sideroblastic anemia terminating in bone marrow aplasia. Amer. J. Clin. Pathol. 50, 467–477.Google Scholar
  56. Brock, J. F., and Diamond, L. K. 1934. Rickets in rats by iron feeding. J. Pediatr. 4, 442–453.CrossRefGoogle Scholar
  57. Brodanová, M., and Hoenig, V. 1966. Iron metabolism in patients with portacaval shunts. Scand. J. Gastroenterol. 1, 167–172.PubMedGoogle Scholar
  58. Brown, E. B., and Justus, B. W. 1958. In vitro absorption of radioiron by everted pouches of rat intestine. Amer. J. Physiol. 194, 319–326.PubMedGoogle Scholar
  59. Brown, E. B., and Rother, M. 1961. Studies of the process of intestinal iron absorption in rats. Blood 18, 780 (abstract).Google Scholar
  60. Brown, E. B., and Rother, M. L. 1963. Studies of the mechanism of iron absorption. I. Iron uptake by the normal rat. J. Lab. Clin. Med. 62, 357–373.PubMedGoogle Scholar
  61. Brown, E. B., Jr., Dubach, R., Smith, D. E., Reynafarje, C., and Moore, C. V. 1957. Studies in iron transportation and metabolism. X. Long-term iron overload in dogs. J. Lab. Clin. Med. 50, 862–893.PubMedGoogle Scholar
  62. Brugsch, J. 1958. Hämochromatose und Melanodermieporphyrie als verschiedene Formen der Hämsynthesestörung bei Pigmentzirrhose und Bronzediabetes. A. Gesamte Inn. Med. 13, 411–415.Google Scholar
  63. Brunner, H.E. 1966. Idiopathische Hämochromatose und Lebercirrhose mit Siderose: Differentialdiagnose durch Untersuchunge der Ferro-und Erythrocytenkinetik mit radioaktiven Eisen (Fe-59) und Chrom (cr-51). Klin. Wochenschr. 44, 1235–1243.PubMedCrossRefGoogle Scholar
  64. Byrd, R. B., and Cooper, T. 1961. Hereditary iron-loading anemia with secondary hemochromatosis. Ann. Intern. Med. 55, 103–123.PubMedCrossRefGoogle Scholar
  65. Callender, S. T. 1973. Fortification of food with iron—is it necessary or effective? In: Nutritional Problems in a Changing World (D. Hollingsworth and M. Russell, eds.), John Wiley and Sons, New York, pp. 205–210.Google Scholar
  66. Cáp, J. Lehotská, V., and Mayerová, A. 1968. Kongenitálna atransferinémia u 11-mesaěného dietata. Cesk. Pediatr. 23, 1020–1025.PubMedGoogle Scholar
  67. Cappell, D. F. 1930. The late results of intravenous injection of colloidal iron. J. Pathol. 33, 175–196.CrossRefGoogle Scholar
  68. Cartwright, G. E., and Wintrobe, M. M. 1954. The anemia of infection. XIX. Studies on free erythrocyte coproporphyrin and protoporphyrin. In: Modern Trends in Blood Diseases (J. F. Wilkinson, ed.). Butterworth, London and Washington, D.C., pp. 183–188.Google Scholar
  69. Case Records of the Massachusetts General Hospital. 1952. Case 38512. N. Engl. J. Med. 247, 992-995.Google Scholar
  70. Case Records of the Massachusetts General Hospital. 1960. Case 46281. N. Engl. J. Med. 263, 88-94.Google Scholar
  71. Cavell, P. A., and Widdowson, E. M. 1964. Intakes and excretions of iron, copper and zinc in the neonatal period. Arch. Dis. Chid. 39, 496–501.CrossRefGoogle Scholar
  72. Chang, H. Y., Robbins, S. L., and Mallory, G. K. 1959. Prolonged intravenous administration of iron to normal and anemic rabbits. Lab. Invest. 8, 1–18.PubMedGoogle Scholar
  73. Charlton, R. W., Jacobs, P., Torrance, J. D., and Bothwell, T. H. 1965. The role of the intestinal mucosa in iron absorption. J. Clin. Invest. 44, 543–554.PubMedCrossRefGoogle Scholar
  74. Chesner, C. 1946. Hemochromatosis: Review of the literature and presentation of a case without pigmentation or diabetes. J. Lab. Clin. Med. 31, 1029–1036.PubMedGoogle Scholar
  75. Chillar, R. K., Johnson, C. S., and Beutler, E. 1976. Erythrocyte pyridoxine kinase levels in patients with sideroblastic anemia. N. Engl. J. Med. 295, 881–883.PubMedCrossRefGoogle Scholar
  76. Chodos, R. B., Ross, J. F., Apt, L., Halkett, J., and Pollycove, M. 1954. The absorption of food iron and inorganic iron by normal, iron-deficient, and hemochromatotic subjects. Clin. Res. Proc. 2, 53 (abstract).Google Scholar
  77. Clément, F., Delaloye, B., and Vannotti, A. 1965. L’exploration isotopique du metabolisme du fer: Anciens et nouveaux modeles. Acta Haematol. (Basel) 33, 65–85.CrossRefGoogle Scholar
  78. Coltman, C. A., Jr. 1969. Pagophagia and iron lack. J. Amer. Med. Assoc. 207, 513–516.CrossRefGoogle Scholar
  79. Conrad, M. E., Jr., and Crosby, W. H. 1963. Intestinal mucosal mechanisms controlling iron absorption. Blood 22, 406–415.PubMedGoogle Scholar
  80. Conrad, M. E., Weintraub, L. R., and Crosby, W. H. 1964. The role of the intestine in iron kinetics. J. Clin. Invest. 43, 963–974.PubMedCrossRefGoogle Scholar
  81. Conrad, M. E., Weintraub, L. R., Sears, D. A., and Crosby, W. H. 1966. Absorption of hemoglobin iron. Amer. J. Physiol. 211, 1123–1130.PubMedGoogle Scholar
  82. Cooley, T. B. 1945. A severe type of hereditary anemia with elliptocytosis: Interesting sequence of splenectomy. Amer. J. Med. Sci. 209, 561–568.Google Scholar
  83. Cotton, H. B., and Harris, J. W. 1962. Familial pyridoxine-responsive anemia. J. Clin. Invest. 41, 1352 (abstract).Google Scholar
  84. Crosby, W. H. 1970. Iron enrichment: One’s food, another’s poison (editorial). Arch. Int. Med. 126, 911–913.CrossRefGoogle Scholar
  85. Crosby, W. H. 1977. Current concepts in nutrition: Who needs iron? New Engl. J. Med. 297, 543–545.PubMedCrossRefGoogle Scholar
  86. Crosby, W. H., and Sheehy, T. W. 1960. Hypochromic iron-loading anaemia: Studies of iron and haemoglobin metabolism by means of vigorous phlebotomy. Brit. J. Haematol. 6, 56–65.CrossRefGoogle Scholar
  87. Cusack, R. P., and Brown, W. D. 1965. Iron deficiency in rats: Changes in body and organ weights, plasma proteins, hemoglobins, myoglobins, and catalase. J. Nutr. 86, 383–393.PubMedGoogle Scholar
  88. Czerniejewski, C. P., Shank, C. W., Bechtel, W. G., and Bradley, W. B. 1964. The minerals of wheat, flour, and bread. Cereal Chem. 41, 67–72.Google Scholar
  89. Dacie, J. V., and Mollin, D. L. 1966. Siderocytes, sideroblasts and sideroblastic anaemia. Acta Med. Scand. Suppl. 445, 237–248.PubMedGoogle Scholar
  90. Dacie, J. V., Smith, M. D., White, J. C., and Mollin, D. L. 1959. Refractory normoblastic anaemia: A clinical and haematological study of seven cases. Brit. J. Haematol. 5, 56–82.CrossRefGoogle Scholar
  91. Dallman, P. R. 1969. Iron restriction in the nursing rat: Early effects upon tissue heme proteins, hemoglobin and liver iron. J. Nutr. 97, 475–480.PubMedGoogle Scholar
  92. Dallman, P. R., and Schwartz, H. C. 1965a. Distribution of cytochrome c and myoglobin in rats with dietary deficiency. Pediatrics 35, 677–686.PubMedGoogle Scholar
  93. Dallman, P. R., and Schwartz, H. C. 1965b. Myoglobin and cytochrome response during repair of iron deficiency in the rat. J. Clin. Invest. 44, 1631–1638.PubMedCrossRefGoogle Scholar
  94. Dameshek, W. 1965. Sideroblastic anaemia: Is this a malignancy? Brit. J. Haematol. 11, 52–58.CrossRefGoogle Scholar
  95. Darby, W. J. 1951. Iron and copper. In: Handbook of Nutrition, 2nd ed. McGraw-Hill (Blakiston), New York, pp. 89–110.Google Scholar
  96. Darnis, F. 1964. Exploration de l’érythropoïèse par le radio-fer 59 dans les hémochromatoses idiopathiques non traitées, et traitées par la méthode des saignées repetées. Med. Monde 40, 159–164.PubMedGoogle Scholar
  97. Da Silve, L. C., Jamra, M. A., Maspes, V., Pontes, J. F., Pieroni, R. R., and de Ulhóa Cintra, A. B. 1963. Pathogenesis of indirect reacting hyperbilirubinemia after portacaval anastomosis. Gastroenterology 44, 117–124.Google Scholar
  98. Davis, A. E., and Biggs, J. C. 1964. Iron absorption in haemochromatosis and cirrhosis of the liver. Aust. Ann. Med. 13, 201–203.PubMedGoogle Scholar
  99. Davis, A. E., and Biggs, J. C. 1965. The pancreas and iron absorption. Gut 6, 140–142.PubMedCrossRefGoogle Scholar
  100. Davis, P. N., Norris, L. C., and Kratzer, F. H. 1968. Iron utilization and metabolism in the chick. J. Nutr. 94, 407–417.PubMedGoogle Scholar
  101. Davis, P. S., Luke, C. G., and Deller, D. J. 1966. Reduction of gastric iron-binding protein in haemochromatosis: A previously unrecognized metabolic defect. Lancet 2, 1431–1433.PubMedCrossRefGoogle Scholar
  102. Debrè, R., Schapira, G., Dreyfus, J. C., and Schapira, F. 1952. Métabolisme du fer chez les descendants de malades atteints de cirrhose bronzée. Bull. Soc. Med. Paris 1, 665–669.Google Scholar
  103. DeGowin, R. L., Sorensen, L. B., Charleston, D. B., Gottschalk, A., and Greenwald, J. H. 1968. Retention of radioiron in the lungs of a woman with idiopathic pulmonary hemosiderosis. Ann. intern. Med. 69, 1213–1220.PubMedCrossRefGoogle Scholar
  104. Deiss, A., and Cartwright, G. E. 1970. Ferritin metabolism in reticulated siderocytes. J. Clin. Invest. 49, 517–523.PubMedCrossRefGoogle Scholar
  105. de Leeuw, N. K. M., Lowenstein, L., and Hsieh, Y. S. 1966. Iron deficiency in hydremia in normal pregnancy. Medicine (Baltimore) 45, 291–315.CrossRefGoogle Scholar
  106. Deller, D. J. 1965. Iron59 absorption measurements by whole-body counting: Studies in alcoholic cirrhosis, hemochromatosis, and pancreatitis. Amer. J. Dig. Dis. 10, 249–258.PubMedCrossRefGoogle Scholar
  107. Derechin, S. S., and Johnson, P. 1962. Red proteins from bovine milk. Nature (London) 194, 473–474.CrossRefGoogle Scholar
  108. Dieckmann, W. J., and Wegner, C. R. 1934. The blood in normal pregnancy. I. Blood in plasma volumes. Arch. Intern. Med. 53, 71–86.CrossRefGoogle Scholar
  109. Dillingham, C. H. 1960. Familial occurrence of hemochromatosis: Report of four cases in siblings. N. Engl. J. Med. 262, 1128–1130.PubMedCrossRefGoogle Scholar
  110. Donati, R. M., Warnecke, M. A., and Gallagher, N. I. 1966. In vivo reticulocyte radioiron assimilation. J. Nucl. Med. 7, 928–934.PubMedGoogle Scholar
  111. Douglas, A. S., and Dacie, J. V. 1953. Incidence and significance of iron-containing granules in human erythrocytes and their precursors. J. Clin. Pathol. 6, 307–313.PubMedCrossRefGoogle Scholar
  112. Dowdle, E. B., Schachter, D., and Schenker, H. 1960. Active transport of Fe59 by everted segments of rat duodenum. Amer. J. Physiol. 198, 609–613.PubMedGoogle Scholar
  113. Drabkin, D. L. 1951. Metabolism of the hemin chromoproteins. Physiol. Rev. 31, 345–431.PubMedGoogle Scholar
  114. Dressel, E. I. B., and Falk, J. E. 1956. Studies on the biosynthesis of blood pigments. 3. Haeme and porphyrin formation from δ-aminolaevulic acid and from porphobilinogen in haemolysed chicken erythrocytes. Biochem. J. 63, 80–87.Google Scholar
  115. Dreyfus, J. C., and Schapira, G. 1963. Metabolisme du fer dans l’hemochromatose. Congr. Franc. Med. (Les Hemochromatoses) 34, 11–34.Google Scholar
  116. Dreyfus, J. C., and Schapira, G. 1964. The metabolism of iron in haemochromatosis. In; Iron Metabolism: An International Symposium (F. Gross, ed.). Springer-Verlag, Berlin, pp. 296–325.CrossRefGoogle Scholar
  117. Dreyfus, J. C., Schapira, G., Schwarzmann, V., and Abbou, R. 1960. Surcharge ferrique hépatique: Forme inapparente chez un fils d’hémochromatosique. Presse Med. 68, 577–578.PubMedGoogle Scholar
  118. Dubach, R., Callender, S. T., and Moore, C. V. 1948. Studies in iron transportation and metabolism: Absorption of radioactive iron in patients with fever and with anemias of varied etiology. Blood 3, 526–540.PubMedGoogle Scholar
  119. Ecker, J. A., Gray, P. A., McKittrick, J. E., and Dickson, D. R. 1968. The development of postshunt hemochromatosis-parenchymal siderosis in patients with cirrhosis occurring after portasystemic shunt surgery: A review of the literature and report of two additional cases. Amer. J. Gastroenterol. 50, 13–29.Google Scholar
  120. Ehrenberg, A., and Laurell, C.-B. 1955. Magnetic measurements on crystallized iron-transferrin isolated from the blood plasma of swine. Acta Chem. Scand. 9, 68–72.CrossRefGoogle Scholar
  121. Ehrenberg, A., and Theorell, H. 1955. Stereochemical structure of cytochrome c. Acta. Chem. Scand. 9, 1193–1205.CrossRefGoogle Scholar
  122. Elves, M. W., Bourne, M. S., and Israeëls, M. C. G. 1966. Pyridoxine-responsive anaemia determined by an X-linked gene. J. Med. Genet. 3, 1–4.PubMedCrossRefGoogle Scholar
  123. Elwood, P. C. 1963. A clinical trial of iron-fortified bread. Brit. Med. J. 1, 224–227.PubMedCrossRefGoogle Scholar
  124. Evans, G. W., and Grace, C. I. 1974. Interaction of transferrin with iron-binding sites on rat intestinal epithelial cell plasma membranes. Proc. Soc. Exp. Biol. Med. 147, 687–689.PubMedGoogle Scholar
  125. Fairbanks, V. F., Fahey, J. L., and Beutler, E. 1971. Clinical Disorders of Iron Metabolism 2nd ed. Grune and Stratton, New York, pp. 1–486.Google Scholar
  126. Farquhar, J. D. 1963. Iron supplementation during first year of life. Amer. J. Dis. Child. 106, 201–206.PubMedGoogle Scholar
  127. Feigelson, P., and Greengard, O. 1961. The activation and induction of trypotophan pyrrolase during experimental porphyria and by amino-triazole. Biochim. Biophys. Acta 52, 509–516.PubMedCrossRefGoogle Scholar
  128. Feuillen, Y. M., and Plumier, M. 1952. Iron metabolism in infants. I. The intake of iron in breastfeedings and artificial feeding (milk and milk foods). Acta Pediatr. (Stockholm) 41, 138–144.Google Scholar
  129. Fielding, J. 1967. Desferrioxamine chelatable body iron. J. Clin. Pathol. 20, 668–670.PubMedCrossRefGoogle Scholar
  130. Fielding, J., O’Shaughnessy, M. C, and Brunström, G. M. 1965. Iron deficiency without anaemia. Lancet 2, 9–12.CrossRefGoogle Scholar
  131. Fielding, J., O’Shaughnessy, M. C., and Brunström, G. M. 1966. Differential ferrioxamine test in idiopathic haemochromatosis and transfusional haemosiderosis. J. Clin. Pathol. 19, 159–164.PubMedCrossRefGoogle Scholar
  132. Finch, C. A., and Bothwell, T. H. 1961. The syndrome of hemochromatosis (editorial). Arch. Intern. Med. (Chicago) 107, 807–810.CrossRefGoogle Scholar
  133. Finch, C. A., Hegsted, M., Kinney, T. D., Thomas, E. D., Rath, C. E., Hoskins, D., Finch, S., and Fluharty, R. G. 1950. Iron metabolism: The pathophysiology of iron storage. Blood 5, 983–1008.PubMedGoogle Scholar
  134. Fischer, H., and Zeile, K. 1929. Syntheses of hematoporhyrin, protoporphyrin, and hemin. Ann. 468,98-116.Google Scholar
  135. Fitch, W. M., and Margoliash, E. 1967. Construction of phylogenetic trees. Science 155, 279–284.PubMedCrossRefGoogle Scholar
  136. Fletcher, J., and Huehns, E. R. 1967. Significance of the binding of iron by transferrin. Nature (London) 215, 584–586.CrossRefGoogle Scholar
  137. Fontès, G., and Thivolle, L. 1925. Sur la teneur du serum en fer non hemoglobinique et sur sa diminution au cours de l’anemie experimentale. C. R. Soc. Bio. (Paris) 93, 687–689.Google Scholar
  138. Foy, H., and Kondi, A. 1957. Anaemias of the tropics: Relation to iron intake, absorption and losses during growth, pregnancy and lactation. J. Trop. Med. Hyg. 60, 105–118.PubMedGoogle Scholar
  139. Freeman, R. M., Vertel, R. M., and Esterling, R. E. 1966. Goodpasture’s syndrome: Prolonged survival with chronic hemodialysis. Arch. Intern. Med. (Chicago) 117, 643–647.CrossRefGoogle Scholar
  140. Fritz, J. C, Pla, G. W., Roberts, T., Baehne, J. W., and Have, E. L. 1970. Biological availability in animals of iron from common dietary sources. Agric. Food Chem 18, 647–651.CrossRefGoogle Scholar
  141. Gabrio, B. W., and Salomon, K. 1950. Distribution of total ferritin in intestine and mesenteric lymph nodes of horses after iron feeding. Proc. Soc. Exp. Biol. Med. 75, 124–127.PubMedGoogle Scholar
  142. Gabrio, B. W., Shoden, A., and Finch, C. A. 1953. A quantitative fractionation of tissue ferritin and hemosiderin. J. Biol. Chem. 204, 815–821.PubMedGoogle Scholar
  143. Gajdos, A. 1966. Les enzymes de la biosynthèse de Thème et leurs anomalies au cours de la thalassémie, l’anémie sidéroachrestique héréditaire et l’anémie sidéroblastique idiopathique acquise. Nouv. Rev. Franc. Hematol. 6, 845–857.Google Scholar
  144. Garby, L., Irnell, L., and Werner, I. 1969a. Iron deficiency in women of fertile age in a Swedish community. II. Efficiency of several laboratory tests to predict the response to iron supplementation. Acta Med. Scand. 185, 107–111.PubMedCrossRefGoogle Scholar
  145. Garby, L., Irnell, L., and Werner, I. 1969b. Iron deficiency in women of fertile age in a Swedish community, III. Estimation of prevalence based on response to iron supplementation. Acta Med. Scand. 185, 113–117.PubMedCrossRefGoogle Scholar
  146. Gardiol, D., Corbat, F., and Magnenat, P. 1967. Un cas d’hémochromatose secondaire après anastomose porto-cave. Schweiz. Med. Wochenschr. 97, 1404–1498.Google Scholar
  147. Garretson, F. D., and Conrad, M. E. 1967. Starch and iron absorption. Proc. Soc. Exp. Biol. Med. 126, 304–308.PubMedGoogle Scholar
  148. Gelpi, A. P., and Ende, N. 1958. An hereidtary anemia with hemochromatosis: Studies on an unusual hemopathic syndrome resembling thalassemia. Amer. J. Med. 25, 303–314.PubMedCrossRefGoogle Scholar
  149. Gemzell, C. A., Robbe, H., and Sjöstrand, T. 1954. Blood volume and total amount of haemoglobin in normal pregnancy and the puerperium. Acta Obstet. Gynecol. Scand. 33, 289–302.PubMedCrossRefGoogle Scholar
  150. Gidari, A. S., and Levere, R. D. 1977. Enzymatic formation and cellular regulation of heme synthesis. Semin. Hematol. 14, 145–168.PubMedGoogle Scholar
  151. Gitlin, D., Kumate, J., Urrusti, J., and Morales, C. 1964. The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus. J. Clin. Invest. 43, 1938–1951.PubMedCrossRefGoogle Scholar
  152. Goldberg, A. 1959. The enzymic formation of haem by the incorporation of iron into protoporphyrin: Importance of ascorbic acid, ergothioneine and glutathione. Brit. J. Haematol. 5, 150–157.CrossRefGoogle Scholar
  153. Goldberg, A., Ashenbrucker, H., Cartwright, G. E., and Wintrobe, M. M. 1956. Studies on the biosynthesis of heme in vitro by avian eryhrocytes. Blood 11, 821–833.PubMedGoogle Scholar
  154. Goldberg, L., and Smith, J. P. 1960. Iron overloading and hepatic vulnerability. Amer. J. Pathol. 36, 125–149.Google Scholar
  155. Goodpasture, E. W. 1919. The significance of certain pulmonary lesions in relation to the etiology of influenza. Amer. J. Med. Sci. 158, 863–870.CrossRefGoogle Scholar
  156. Gordon, W. G., Ziegler, J., and Basch, J. J. 1962. Isolation of an iron-binding protein from cow’s milk. Biochim. Biophys. Acta 60, 410–411.CrossRefGoogle Scholar
  157. Grace, N. D., and Balint, J. A. 1966. Hemochromatosis associated with end-to-side portacaval anastomosis. Amer. J. Dig. Dis. N. Ser. 11, 351–358.CrossRefGoogle Scholar
  158. Granick, S. 1946. Ferritin. IX. Increase of the protein apoferritin in the gastrointestinal mucosa as a direct response to iron feeding. The function of ferritin in the regulation of iron absorption. J. Biol. Chem. 164, 737–746.PubMedGoogle Scholar
  159. Granick, S. 1951. Structure and physiological functions of ferritin. Physiol. Rev. 31, 489–511.PubMedGoogle Scholar
  160. Granick, S., and Michaelis, L. 1942. Ferritin and apoferritin. Science 95, 439–440.PubMedCrossRefGoogle Scholar
  161. Green, S., and Mazur, A. 1957. Relation of uric acid metabolism to release of iron from hepatic ferritin. J. Biol. Chem. 227, 653–668.Google Scholar
  162. Green, S., Saha, A. K., Carleton, A. W., and Mazur, A. 1958. Release of storage iron to the plasma by xanthine oxidase after purine administration. Fed. Proc. Fed. Amer. Soc. Exp. Biol. 17, 233.Google Scholar
  163. Groves, M. L. 1960. The isolation of a red protein from milk. J. Amer. Chem. Soc. 82, 3345–3350.CrossRefGoogle Scholar
  164. Gutelius, M. F., Millican, F. K., Layman, E. M., Cohen, G. J., and Dublin, C. C. 1962. Nutritional studies of children with pica. II. Treatment of pica with iron given intramuscularly. Pediatrics 29, 1018–1023.Google Scholar
  165. Haden, R. L. 1932. Simple achlorhydric anemia. J. Amer. Med. Assoc. 99, 1398–1404.CrossRefGoogle Scholar
  166. Hahn, P. F., Bale, W. F., Lawrence, E. O., and Whipple, G. H. 1939. Radioactive iron and its metabolism in anemia: Its absorption, transportation, and utilization. J. Exp. Med. 69, 739–753.PubMedCrossRefGoogle Scholar
  167. Hahn, P. F., Bale, W. F., Ross, J. F., Balfour, W. M., and Whipple, G. H. 1943. Radioactive iron absorption in gastro-intestinal tract: Influence of anemia, anoxia, and antecedent feeding distribution in growing dogs. J. Exp. Med. 78, 169–188.PubMedCrossRefGoogle Scholar
  168. Hallberg, L., and Sölvell, L. 1967. Absorption of hemoglobin iron in man. Acta Med. Scand. 181, 335–354.PubMedCrossRefGoogle Scholar
  169. Hallgren, B. 1954. Haemoglobin formation and storage of iron in protein deficiency. Acta Soc. Med. Ups. 59, 79–208.PubMedGoogle Scholar
  170. Halsted, J. A., Prasad, A. S., and Nadimi, M. 1965. Gastrointestinal function in iron deficiency anemia. AMA Arch. Intern. Med. 66, 508–516.Google Scholar
  171. Hamilton, E., Williams, R., Barlow, K. A., and Smith, P. M. 1968. The arthropathy of idiopathic haemochromatosis. Q. J. Med. 37, 171–182.PubMedGoogle Scholar
  172. Handler, P., Rajogopalan, K. V., and Aleman, V. 1964. Structure and function of iron flavoproteins. Fed. Proc. Fed. Amer. Soc. Exp. Biol. 23, 30–38.Google Scholar
  173. Hansen, H. A., and Weinfeld, A. 1959. Hemosiderin estimations and sideroblast counts in the differential diagnosis of iron deficiency and other anemias. Acta Med. Scand. 165, 333–356.PubMedCrossRefGoogle Scholar
  174. Harris, C. 1957. The vicious circle of anaemia and menorrhagia. Canad. Med. Assoc. J. 77, 98–100.PubMedGoogle Scholar
  175. Harris, E. B., MacGibbon, B. H., and Mollin, D. L. 1965. Experimental sideroblastic anaemia. Brit. J. Haematol. 11, 99–106.CrossRefGoogle Scholar
  176. Harris, J. W., Whittington, R. M., Weisman, R., Jr., and Horrigan, D. L. 1956. Pyridoxine responsive anemia in the human adult. Proc. Soc. Exp. Biol. Med. 91, 427–432.PubMedGoogle Scholar
  177. Harrison, P. M. 1977. Ferritin: An iron-storage molecule. Semin. Hematol. 14, 55–70.PubMedGoogle Scholar
  178. Hartman, R. S., Conrad, M. E., Jr., Hartman, R. E., Joy, R. J. T., and Crosby, W. H. 1963. Ferritin-containing bodies in human small intestinal epithelium. Blood 22, 397–405.PubMedGoogle Scholar
  179. Hawksley, J. C, Lightwood, R., and Bailey, U. M. 1934. Iron deficiency anaemia in children: Its association with gastrointestinal disease, achlorhydria and haemorrhage. Arch. Dis. Child. 9, 359–372.PubMedCrossRefGoogle Scholar
  180. Hayhoe, F. G., and Quaglino, D. 1960. Refractory sideroblastic anaemia and erythaemic myelosis: Possible reltionship and cytochemical observations. Brit. J. Haematol. 6, 381–387.CrossRefGoogle Scholar
  181. Heath, C. W., and Patek, A. J., Jr. 1937. Anemia of iron deficiency. Medicine (Baltimore) 16, 267–350.Google Scholar
  182. Heath, C. W., Strauss, M. B., and Castle, W. B. 1932. Quantitative aspects of iron deficiency in hypochromic anemia (the parenteral administration of iron). J. Clin. Invest. 11, 1293–1312.PubMedCrossRefGoogle Scholar
  183. Hegsted, D. M., Finch, C. A., and Kinney, T. D. 1949. The influence of diet on iron absorption. II. The interrelation of iron and phosphorus. J. Exp. Med. 90, 147–156.PubMedCrossRefGoogle Scholar
  184. Heilmeyer, L. 1966. Disturbances in Heme Synthesis: Special Considerations of the Side-roachrestic Anemias and Erythropoietc Porphyrias. Charles C. Thomas, Springfield, Illinois, pp. 103–178.Google Scholar
  185. Heilmeyer, L., and Plötner, K. 1937. Das Serumeisen und die Eisenmangelkrankheit (Pathogenese, Symptomatologie und Therapie). G. Fischer, Jena, Germany, pp. 1–92.Google Scholar
  186. Heilmeyer, L., Emmrich, J., Hennenann, H. H., Schubothe, H., Keiderling, W., Lee, M. H., Bilger, R., and Bemauer, W. 1957. Über eine neuartige hypochrome Anämie bei zwei Geschwistern auf der Grundlage einer Eisenverwertungsstörung: Anaemia sideroachrestica hereditaria. Schweiz. Med. Wochenschr. 87, 1237–1238.PubMedGoogle Scholar
  187. Heilmeyer, L., Keller, W., Vivell, O., Betke, K., Wöehler, F., and Keiderling, W. 1961. Die kongenitale Atransferrinämie. Schweiz. Med. Wochenschr. 91, 1203–1205.PubMedGoogle Scholar
  188. Heiner, D. C, Sears, J. W., and Kniker, W. T. 1962. Multiple precipitins to cow’s milk in chronic respiratory disease: A syndrome including poor growth, gastrointestinal symptoms, evidence of allergy, iron deficiency anemia, and pulmonary hemosiderosis. Amer. J. Dis. Child. 103, 634–654.PubMedGoogle Scholar
  189. Heinrich, H. C. 1968. Iron deficiency without anaemia. Lancet 2, 460.PubMedCrossRefGoogle Scholar
  190. Hines, J. D. 1969. Reversible megaloblastic and sideroblastie marrow abnormalities in alcoholic patients. Brit. J. Haematol. 16, 87–101.CrossRefGoogle Scholar
  191. Hines, J. D. 1975. Hématologie abnormalities involving vitamin B6 and folate metabolism in alcoholic subjects. Ann. N. Y. Acad. Sci. 252, 316–327.PubMedCrossRefGoogle Scholar
  192. Hines, J. D., and Grasso, J. A. 1970. The sideroblastic anemias. Semin. Hematol. 7, 86–106.PubMedGoogle Scholar
  193. Hines, J. D., and Harris, J. M. 1964. Pyridoxine-responsive anemia: Description of three patients with megaloblastic erythropoiesis. Amer. J. Clin. Nutr. 14, 137–146.PubMedGoogle Scholar
  194. Hiyeda, K. 1939. The cause of Kaschin-Beck’s disease. Jpn. J. Med. Sci. Biol. 4, 91–106.Google Scholar
  195. Hoffbauer, F. W. 1960. Primary biliary cirrhosis: Observations on the natural course of the disease in 25 women. Amer. J. Dig. Dis. 5, 348–383.PubMedCrossRefGoogle Scholar
  196. Holmberg, C. G., and Laurell, C.-B. 1947. Investigations in serum copper. I. Nature of serum copper and its relation to the iron-binding protein in human serum. Acta Chem. Scand. 1, 944–950.PubMedCrossRefGoogle Scholar
  197. Horeau, J., Nicolas, G., Lerous, M.-J., Babin-Chevaye, L., and Robin, C. 1964. Étude anatomo-clinique du coeur dans l’hémochromatose idiopathique. Med. Monde 40, 132–136.PubMedGoogle Scholar
  198. Horns, H. L. 1949. Hemochromatosis: Cardiac failure associated with extensive hemosiderosis of the myocardium. Amer. J. Med. 6, 272–274.PubMedCrossRefGoogle Scholar
  199. Horrigan, D. L., and Harris, J. W. 1964. Pyridoxine-responsive anemia: Analysis of 62 cases. Adv. Intern. Med. 12, 103–174.PubMedGoogle Scholar
  200. Houston, J. C. 1951. Haemochromatosis and refractory anemia. Guy Hosp. Rep. 100, 355–361.Google Scholar
  201. Hwang, Y.-F., and Brown, E. B. 1964. Evaluation of deferoxamine in iron overload. Arch. Intern. Med. (Chicago) 114, 741–753.CrossRefGoogle Scholar
  202. Ingram, D. J. E., Gibson, J. F., and Perutz, M. F. 1956. Orientation of the four haem groups in haemoglobin. Nature (London) 178, 906–908.CrossRefGoogle Scholar
  203. Jacob, F., and Monod, J. 1961. Genetic regulatory mechanisms in the synthesis of proteins. J. Mol. Biol., 3, 318-356PubMedCrossRefGoogle Scholar
  204. Jacobs, A., and Butler, E. B. 1965. Menstrual blood-loss in iron-deficiency anaemia. Lancet 2, 407–409.PubMedCrossRefGoogle Scholar
  205. Jacobs, A., Kilpatrick, G. S., and Withey, J. L. 1965. Iron deficiency anaemia in adults: Prevalence and prevention. Postgrad. Med. J. 41, 418–424.PubMedCrossRefGoogle Scholar
  206. Jacobs, P., Bothwell, T. H., and Charlton, R. W. 1966. Intestinal iron transport: Studies using a loop of gut with an artificial circulation. Amer. J. Physiol. 210, 694–700.PubMedGoogle Scholar
  207. Jandl, J. H., and Katz, J. H. 1963. The plasma-to-cell cycle of transferrin. J. Clin. Invest. 42, 314–326.PubMedCrossRefGoogle Scholar
  208. Jandl, J. H., Inman, J. K., Simmons, R. L., and Allen, D. W. 1959. Transfer of iron from serum iron-binding protein to human reticulocytes. J. Clin. Invest. 38, 161–185.PubMedCrossRefGoogle Scholar
  209. Johannson, B. 1960. Isolation of iron-containing red protein from human milk. Acta Chem. Scand. 14, 510–512.CrossRefGoogle Scholar
  210. Johnson, B. F. 1968. Hemochromatosis resulting from prolonged oral iron therapy. N. Engl. J. Med. 278, 1100–1101.PubMedCrossRefGoogle Scholar
  211. Josephs, H. W. 1959. The iron of the newborn baby. Acta Paediatr. (Stockholm) 48, 403–418.Google Scholar
  212. Kaldor, I. 1958. Studies on intermediary iron metabolism. XII. Measurement of the iron derived from water soluble and water insoluble non-haem compounds (ferritin and haemosiderin iron) in liver and spleen. Austral. J. Exp. Biol. 36, 173–182.PubMedCrossRefGoogle Scholar
  213. Kaplan, E., Zuelzer, W. W., and Mouriquand, C. 1954. Sideroblasts: Study of stainable nonhemoglobin iron in marrow normoblasts. Blood 9, 203–213.PubMedGoogle Scholar
  214. Katz, J. H. 1965. The delivery of iron to the immature red cell: A critical review. Ser. Haematol. 6, 15–29.Google Scholar
  215. Kelly, A. B. 1919. Spasm at the entrance to the esophagus. J. Laryngol. 34, 285–289.Google Scholar
  216. Kennedy, W. P. U., Shearman, D. J. C, Delamore, I. W., Simpson, J. D., Black, J. W., and Grant, I. W. B. 1966. Idiopathic pulmonary haemosiderosis with myocarditis: Radioisotope studies in a patient treated with prednisone. Thorax 21, 220–229.PubMedCrossRefGoogle Scholar
  217. Keschner, H. W. 1951. The heart in hemochromatosis. South. Med. J. 44, 927–930.PubMedCrossRefGoogle Scholar
  218. Kinney, T. D., Hegsted, D. M., and Finch, C. A. 1949. The influence of diet on iron absorption. I. The pathology of iron excess. J. Exp. Med. 90, 137–146.PubMedCrossRefGoogle Scholar
  219. Kra, S. J., Hollingsworth, J. W., and Finch, S. C. 1965. Arthritis with synovial iron deposition in a patient with hemochromatosis. N. Engl. J. Med. 272, 1268–1271.PubMedCrossRefGoogle Scholar
  220. Kroe, D. J., Kaufman, N., Klavins, J. V., and Kinney, T. D. 1966. Interrelation of amino acids and pH in intestinal iron absorption. Amer. J. Physiol. 211, 414–418.PubMedGoogle Scholar
  221. Krumbhaar, E. B., and Chanutin, A. 1922. Studies on experimental plethora in dogs and rabbits. J. Exp. Med. 35, 847–871.PubMedCrossRefGoogle Scholar
  222. Kuhn, E., Brodan, V., Brodanova, M., and Friedmann, B. 1967. Influence of sleep deprivation on iron metabolism. Nature (London) 213, 1041–1042.CrossRefGoogle Scholar
  223. Kurth, D., Deiss, A., and Cartwright, G. E. 1969. Circulating siderocytes in human subjects. Blood 34, 754–764.PubMedGoogle Scholar
  224. Kushner, J. P., Lee, G. R., Wintrobe, M. M., and Cartwright, G. E. 1971. Idiopathic refractory sideroblastic anemia: Clinical and laboratory investigation of 17 pateints and review of the literature. Medicine (Baltimore) 50, 139–158.Google Scholar
  225. Lamont, N. McE., and Hathorn, M. 1960. Increased plasma iron and liver pathology in Africans with porphyria. S. Afr. Med. J. 34, 279–281.PubMedGoogle Scholar
  226. Langhof, H., and Mildschlag, G. 1954. Aktinisch-traumatisch-bullöse Porphyrin-dermatose kombiniert mit beginnender Hamöchromatose. Arch. Dermatol. 199, 21–32.CrossRefGoogle Scholar
  227. Laufberger, V. 1937. Sur la cristallisation de la ferritine. Bull. Soc. Chim. Biol. (Paris) 19, 1575–1582.Google Scholar
  228. Laurell, C.-B. 1952. Plasma iron and the transport of iron in the organism. Pharmacol. Rev. 4, 371–395.PubMedGoogle Scholar
  229. Layrisse, M., Martinex-Torres, C, Valez, F., and Gonzalez, M. 1976. Sugar as a vehicle for iron fortification. Am. J. Clin. Nutr. 29, 8–18.PubMedGoogle Scholar
  230. Leading article: Iron deficiency without anaemia. 1968. Lancet 1, 462-463.Google Scholar
  231. Lee, G. R., Cartwright, C. E., and Wintrobe, M. M. 1966. The response of free erythrocyte protoporphyrin to pyridoxine therapy in a patient with sideroachrestic (sideroblastic) anemia. Blood 27, 557–567.PubMedGoogle Scholar
  232. Lee, G. R., MacDiarmid, W. D., Cartwright, G. E., and Wintrobe, M. M. 1968. Hereditary X-linked sideroachrestic anemia. The isolation of two erythrocyte populations differing in Xga blood type and porphyrin content. Blood 32, 59–70.PubMedGoogle Scholar
  233. Lee, S. L., Rosner, F., Rivero, I., Feldman, F., and Hurwitz, A. 1965. Refractory anemia with abnormal iron metabolism: Its remission after resection of hyperplastic mediastinal lymph nodes. N. Engl. J. Med. 272, 761–766.PubMedCrossRefGoogle Scholar
  234. Lees, F., and Rosenthal, F. D. 1958. Gastric mucosal lesions before and after treatment in iron deficiency anemia. Q. J. Med. 27, 19–26.PubMedGoogle Scholar
  235. Lichtman, H. C, and Feldman, F. 1963. In vitro pyrrole and porphyrin synthesis in lead poisoning and iron deficiency. J. Clin. Invest. 42, 830–839.PubMedCrossRefGoogle Scholar
  236. Lipschitz, D. A., Cook, J. D., and Finch, C. A. 1974. A clinical evaluation of serum ferritin as an index of iron stores. N. Engl. J. Med. 290, 1213–1216.PubMedCrossRefGoogle Scholar
  237. Losowsky, M. S. 1966. Effects of desferrioxamine in patients with iron-loading with a simple method for estimating urinary iron. J. Clin. Pathol. 19, 165–169.PubMedCrossRefGoogle Scholar
  238. Losowsky, M. S., and Hall, R. 1965. Hereditary sideroblastic anaemia. Brit. J. Haematol. 11, 70–85.CrossRefGoogle Scholar
  239. Losowsky, M. S., and Wilson, A. R. 1967. Whole-body counting of the absorption and distribution of iron in haemochromatosis. Clin. Sci. 32, 151–160.PubMedGoogle Scholar
  240. Lukl, P., Wiedermann, B., and Barborik, M. 1958. Hereditäre Leptocytsen-anämie bei Männern mit Hämochromatose. Folia Haematol.(Leipzig) 3, 17–45.Google Scholar
  241. Lumeng, L., and Li, T. K. 1974. Vitamin B6 metabolism in chronic alcohol abuse: Pyridoxal phosphate levels in plasma and the effects of acetaldehyde on pyridoxal phosphate synthesis and degradation in erythrocytes. J. Clin. Invest. 53, 693–704.PubMedCrossRefGoogle Scholar
  242. Liithi, H., Sordat, B., and Bütler, R. 1968. Therapieresistente Anämie und humorale Veränderungen bei plasmacellulärem hämosiderotischem Tumor im Mesenterium: Ein besonderes Syndrom? Schweiz. Med. Wochenschr. 98, 816–821.Google Scholar
  243. MacDonald, R. A. 1960. Experimental pigment cirrhosis: Its production in rats by feeding a choline-deficient diet with excess iron. Amer. J. Pathol. 36, 499–519.Google Scholar
  244. MacDonald, R. A. 1963. Idiopathic hemochromatosis: Genetic or acquired? Arch. Intern. Med. (Chicago) 112, 184–190.CrossRefGoogle Scholar
  245. MacDonald, R. A. 1964. Hemochromatosis and Hemosiderosis. Charles C. Thomas, Springfield, Illinois, pp. 1–374.Google Scholar
  246. MacDonald, R. A., and Mallory, G. K. 1960. Hemochromatosis and hemosiderosis: Study of 211 autopsied cases. Arch. Intern. Med. (Chicago) 105, 686–700.CrossRefGoogle Scholar
  247. MacDonald, R. A., and Pechet, G. S. 1965. Experimental hemochromatosis in rats. Amer. J. Pathol. 46, 85–109.Google Scholar
  248. MacDonald, R. A., Jones, R. S., and Pechet, G. S. 1965. Folic acid deficiency and hemochromatosis. Arch. Pathol. (Chicago) 80, 153–160.Google Scholar
  249. MacDonald, R. A., Endo, H., and Pechet, G. S. 1968a. Pathogenesis of experimental hemochromatosis: Reticuloendothelial system disorder and excess iron. Gastroenterology 54, 161 (abstract).Google Scholar
  250. MacDonald, R. A., Endo, H., and Pechet, G. S. 1968b. Studies of experimental hemochromatosis: Disorder of the reticuloendothelial system and excess iron. Arch. Pathol. (Chicago) 85, 366–387.Google Scholar
  251. MacGibbon, B. H., and Mollin, D. L. 1965. Sideroblastic anaemia in man: Observations on seventy cases. Brit. J. Haematol. 11, 59–69.CrossRefGoogle Scholar
  252. MacGregor, C. S., Johnson, R. S., and Turk, K. A. D. 1960. Fatal nephritis complicating idiopathic pulmonary haemosiderosis in young adults. Thorax 15, 198–203.CrossRefGoogle Scholar
  253. Maddock, R. K., Jr., Stevens, L. E., Reemtsma, K., and Bloomer, H. A. 1967. Goodpasture’s syndrome: Cessation of pulmonary hemorrhage after bilateral nephrectomy. Ann. Intern. Med. 67, 1258–1264.PubMedCrossRefGoogle Scholar
  254. Mahler, H. R., and Elowe, D. G. 1953. DPNH-cytochrome reductase, a ferro-flavo protein. J. Amer. Chem. Soc. 75, 5769–5770.CrossRefGoogle Scholar
  255. Maier, C. 1966. Eisenmangel ohne Anämie: Die Hämatologie des praktischen Arztes. Praxis 55, 54–58.Google Scholar
  256. Margoliash, E., Frohwirt, N., and Wiener, E. 1959. A study of the cytochrome C haemochromogen. Biochem. J. (London) 71, 559–570.Google Scholar
  257. Martinez-Torres, C, and Layrisse, M. 1974. Interest for the study of dietary absorption and iron fortification. World Rev. Nutr. Dietet. 19, 51–70.Google Scholar
  258. Matsaniotis, N., Karpouzas, J., Apostolopoulo, E., and Messaritakis, J. 1968. Idiopathic pulmonary haemosiderosis in children. Arch. Dis. Child. 43, 307–309.PubMedCrossRefGoogle Scholar
  259. Mazur, A., Green, S., Sana, A., and Carleton, A. 1958. Mechanism of release of ferritin iron in vivo by xanthine oxidase. J. Clin. Invest. 37, 1809–1817.PubMedCrossRefGoogle Scholar
  260. McCance, R. A., and Widdowson, E. M. 1937. Absorption and excretion of iron. Lancet 2, 680–684.CrossRefGoogle Scholar
  261. McCance, R. A., and Widdowson, E. M. 1938. The absorption and excretion of iron following oral and intravenous administration. J. Physiol. (London) 94, 148–154.Google Scholar
  262. McCance, R. A., and Widdowson, E. M. 1951. Composition of the body. Brit. Med. Bull. 7, 297–306.PubMedGoogle Scholar
  263. McFarlane, D. B., Pinkerton, P. H., Dagg, J. H., and Goldberg, A. 1967. Incidence of iron deficiency, with and without anaemia, in women in general practice. Brit. J. Haematol. 13, 790–796.CrossRefGoogle Scholar
  264. Mendel, G. A. 1961. Studies on iron absorption. I. The relationships between the rate of erythropoiesis, hypoxia and iron absorption. Blood 18, 727–736.PubMedGoogle Scholar
  265. Mendel, G. A., Weiler, R. J., and Mangalik, A. 1963. Studies on iron absorption. II. The absorption of iron in experimental anemias of diverse etiogy. Blood 22, 450–458.PubMedGoogle Scholar
  266. Mengel, C. E., Carter, W. A., and Horton, E. S. 1964. Geophagia with iron deficiency and hypokalemia: Cachexia Afrikana. Arch. Intern. Med. (Chicago) 114, 470–474.CrossRefGoogle Scholar
  267. Mielke, H. G. 1953. Hämochromatose—ein seltenes Krakheitsbild bei der Frau. Arztl. Wochnschr. 8, 646–648.Google Scholar
  268. Minnich, V., Okcuoglu, A., Tarcon, Y., Arcasoy, A., Cin, S., Yörükoglu, O., Renda, F. and Demirag, B. 1968. Pica in Turkey. II. Effect of clay upon iron absorption. Amer. J. Clin. Nutr. 21, 78–86.PubMedGoogle Scholar
  269. Mollin, D. L. 1965. Sideroblasts and sideroblastic anemia. Brit. J. Hematol. 11, 41–48.CrossRefGoogle Scholar
  270. Monsen, E. R., Kuhn, I. N., and Finch, C. A. 1967. Iron status of menstruating women. Amer. J. Clin. Nutr. 20, 842–849.PubMedGoogle Scholar
  271. Moore, C. V. 1955 The importance of nutritional factors in the pathogène sis of iron-deficiency anemia. Amer. J. Clin. Nutr. 3, 3–10.PubMedGoogle Scholar
  272. Moore, C. V., and Dubach, R. 1951. Observations on absorption of iron from foods tagged with radioiron. Trans. Assoc. Amer. Physicians 64, 245–256.Google Scholar
  273. Moore, C. V., and Dubach, R. 1956. Metabolism and requirements of iron in the human. J. Amer. Med. Assoc. 162, 197–204.CrossRefGoogle Scholar
  274. Moore, C. V., Doan, C. A., and Arrowsmith, W. R. 1937. Studies in iron transportation and metabolism; mechanism of iron transportation: Its significance in iron utilization in anemic states of varied etiology. J. Clin. Invest. 16, 627–1937.PubMedCrossRefGoogle Scholar
  275. Morgan, E. H. 1961. Plasma-iron and haemoglobin levels in pregnancy: The effect of oral iron. Lancet 1, 9–12.PubMedCrossRefGoogle Scholar
  276. Morgan, E. H. 1963. Exchange of iron and transferrin across endothelial surfaces in the rat and rabbit. J. Physiol. (London) 169, 339–352.Google Scholar
  277. Morgan, E. H. 1964a. The interaction between the rabbit, human and rat transferrin and reticulocytes. Brit. J. Haematol. 10, 442–452.CrossRefGoogle Scholar
  278. Morgan, E. H. 1964b. Passage of transferrin, albumin, and gamma globulin from maternal plasma to fetus in the rat and rabbit. J. Physiol. (London) 171, 26–41.Google Scholar
  279. Morgan, E. H., and Appleton, T. C. 1969. Autoradiographic localization of 125-I-labelled transferrin in rabbit reticulocytes. Nature (London) 223, 1371–1372.CrossRefGoogle Scholar
  280. Morgan, E. H., and Baker, E. 1969. The effect of metabolic inhibitors on transferrin and iron and transferrin release from reticulocytes. Biochim. Biophys. Acta 184, 442–454.PubMedCrossRefGoogle Scholar
  281. Morgan, E. H., and Laurell, C. B. 1963. Studies on the exchange of iron between transferrin and reticulocytes. Brit. J. Haematol. 9, 471–483.CrossRefGoogle Scholar
  282. Morgan, E. H., and Walters, M. N. I. 1963. Iron storage in human disease: Fractionation of hepatic and splenic iron into ferritin and haemosiderin with histochemical correlations. J. Clin. Pathol. 16, 101–107.PubMedCrossRefGoogle Scholar
  283. Morgan. E. H., Huehns, E. R., and Finch, C. A. 1966. Iron reflux from reticulocytes and bone marrow cells in vitro. Amer. J. Physiol. 210, 579–585.PubMedGoogle Scholar
  284. Morningstar, W. A. 1955. Exogenous hemochromatosis: A report of three cases. Arch. Pathol. (Chicago) 59, 355–358.Google Scholar
  285. Morrison, S. D. 1952. Human milk yield, proximate principles, and inorganic constituents. Tech. communication No. 18 of Commonwealth Bureau of Animal Nutrition, Rowell Research Institute, Backsburn, Aberdeenshire, Scotland, Commonwealth Agricultural Bureau, Farnham Royal Slough, Bucks, England, pp. 1–99.Google Scholar
  286. Morse, W. I., and Read, H. C. 1954. Stainable iron in marrow cells and erythrocytes in anemia. Canad. Serv. Med. J. 10, 244–252.Google Scholar
  287. Muir, A. R. 1960. The molecular structure of isolated and intracellular ferritin. Quart. J. Exp. Physiol. Cogn. Med. Sci. 45, 192–201.Google Scholar
  288. Mukherjee, C, and Mukherjee, S. K. 1953. Studies in iron metabolism in anaemias in pregnancy. J. Indian Med. Assoc. 22, 345–351.PubMedGoogle Scholar
  289. Munro, J. F., Geddes, A. M., and Lamb, W. L. 1967. Goodpasture’s syndrome: Survival after acute renal failure. Brit. Med. J. 4, 95.PubMedCrossRefGoogle Scholar
  290. Murphy, K. J. 1965. Pulmonary haemosiderosis (apparently idiopathic) associated with myocarditis, with bilateral penetrating corneal ulcération, and with diabetes mellitus. Thorax 20, 341–347.PubMedCrossRefGoogle Scholar
  291. National Health and Medical Research Council Report (Canberra), No. 1. 1945.Google Scholar
  292. Neerhout, R. C, Larson, W., and Mansur, P. 1969. Mesenteric lymphoid hamartoma associated with chronic hypoferremia, anemia, growth failure, and hyperglobulinemia. N. Engl. J. Med. 280, 922–925.PubMedCrossRefGoogle Scholar
  293. Niccum, W. L., Jackson, R. L., and Stearns, G. 1953. Use of ferric and ferrous iron in the prevention of hypochromic anemia in infants. Amer. J. Dis. Child. 96, 5533–5567.Google Scholar
  294. Nissim, J. A. 1953. Experimental siderosis: A study of the distribution, delayed effects, and metabolism of massive amounts of various iron preparations. J. Pathol. 66, 185–204.CrossRefGoogle Scholar
  295. Nixon, D. D. 1966. Spontaneous shunt siderosis. Amer. J. Dig. Dis. 11, 359–366.PubMedCrossRefGoogle Scholar
  296. Noyes, W. D., Bothwell, T. H., and Finch, C. A. 1960. The role of the reticulo-endothelial cell in iron metabolism. Brit. J. Haematol. 6, 43–55.CrossRefGoogle Scholar
  297. Noyes, W. D., Hosain, F., and Finch, C. A. 1964. Incorporation of radioiron into marrow heme. J. Lab. Clin. Med. 64, 574–580.PubMedGoogle Scholar
  298. O’Dell, B. L., Hardwock, B. C, and Reynolds, G. 1961. Mineral deficiencies of milk and congenital malformations in the rat. J. Nutr. 73, 151–157.Google Scholar
  299. Osaki, S., and Sirivech, S. 1971. Identification and partial purification of ferritin reducing enzyme in liver. Fed. Proc. Fed. Am. Soc. Exp. Biol. 30, 1292 (abstract)Google Scholar
  300. Palacio, J., Sanchez, B., Hojman, D., and Perez, A. H. 1960. Hemochromatosis: Forma cardiaca juvenil. Prensa Med. Argent. 47, 2943–2949.PubMedGoogle Scholar
  301. Paléus, S., Ehrenberg, A., and Tuppy, H. 1955. II Investigation of the linkage between peptide moiety and prosthetic group. Acta Chem. Scand. 9, 365–374.CrossRefGoogle Scholar
  302. Paterson, D. R. 1919. A clinical type of dysphagia. J. Laryngol. 24, 289–291.Google Scholar
  303. Patterson, J. C. S., Marrack, D., and Wiggins, H. S. 1953. The diurnal variation of the serum iron level in erythropoietic disorders. J. Clin. Pathol. 6, 105–109.CrossRefGoogle Scholar
  304. Perkins, K. W., Mclnnes, I. W. S., Blackburn, C. R. B., and Beal, R. W. 1965. Idiopathic haemochromatosis in children: Report of a family. Amer. J. Med. 39, 118–126.PubMedCrossRefGoogle Scholar
  305. Peterson, R. E., and Ettinger, R. H. 1953. Radiactive iron absorption in siderosis (hemochromatosis) of the liver. Amer. J. Med. 15, 518–524.PubMedCrossRefGoogle Scholar
  306. Petit. D. W. 1945. Hemochromatosis with complete heart block: With a discussion of the cardiac complications. Amer. Heart J. 29, 253–260.CrossRefGoogle Scholar
  307. Pirzio-Biroli, G., Bothwell, T. H., and Finch, C. A. 1958. Iron absorption. II. The absorption of radioiron administered with a standard meal in man. J. Lab. Clin. Med. 51, 37–48.PubMedGoogle Scholar
  308. Platzer, R. F., Young, L. E., and Yuile, C. L. 1955. Hemosiderosis resembling hemochromatosis following multiple transfusions. Acta Haematol. (Basel) 14, 185–192.CrossRefGoogle Scholar
  309. Pletcher, W. D., Brody, G. L., and Meyers, M. C. 1963. Hemochromatosis following prolonged iron therapy in a patient with hereditary nonspherocytic hemolytic anemia. Amer. J. Med. Sci. 246, 27–34.PubMedCrossRefGoogle Scholar
  310. Ploem, J. E., Wael, J. de, Verloop, M. C, and Punt, K. 1966. Sideruria following a single dose of desferrioxamine-B as a diagnostic test in iron overload. Brit. J. Haematol. 12, 396–408.CrossRefGoogle Scholar
  311. Pollycove, M. 1958. Iron kinetics. In: Iron in Clinical Medicine (R. O. Wallerstein and S. R. Mettier, eds.). University of California Press, Berkeley, pp. 43–57.Google Scholar
  312. Pollycove, M., and Mortimer, R. 1961. The quantitative determination of iron kinetics and hemoglobin synthesis in human subjects. J. Clin. Invest. 40, 753–782.PubMedCrossRefGoogle Scholar
  313. Poison, C. J. 1929a. The storage of iron following its oral and subcutaneous administration. Q. J. Med. 23, 77–84.CrossRefGoogle Scholar
  314. Poison, C. J. 1919b. The fate of colloidal iron administered intravenously. II. Long experiments. J. Pathol. 32, 247–260.Google Scholar
  315. Popper, H. P., and Schaffner, F. 1957. Liver: Structure and function. McGraw-Hill, New York, 777 pp.Google Scholar
  316. Portella, A., Guida, V., and Valerio, V. 1957. Su di un caso di emocromatosi giovanile con alterazioni endocrine. Riforma Med. 71, 1246–1254.PubMedGoogle Scholar
  317. Powell, L. W., and Thomas, M. J. 1967. Use of diethylenetriamine penta-acetic acid (D.T.P.A.) in the clinical assessment of total body iron stores. J. Clin. Pathol. 20, 896–904.PubMedCrossRefGoogle Scholar
  318. Prasad, A. S. 1966. Zinc metabolism and its deficiency in human subjects, In: Zinc Metabolism (A. S. Prasad, ed.). Charles C. Thomas, Springfield, Illinois, pp. 250–302.Google Scholar
  319. Prasad, A. S., and Oberleas, D. 1971. Binding of iron to amino acids and serum proteins in vitro. Proc. Soc. Exp. Biol. Med. 138, 932–935.PubMedGoogle Scholar
  320. Prasad, A. S., Halsted, J. A., and Nadimi, M. 1961. Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism, and geophagia. Amer. J. Med. 31, 532–546.PubMedCrossRefGoogle Scholar
  321. Prasad, A. S., Tranchida, L., Konno, E. T., Berman, L., Albert, S. Sing, C. F., and Brewer, G. J. 1968. Hereditary sideroblastic anemia and glucose-6-phosphate dehydrogenase deficiency in a Negro family. J. Clin. Invest. 47, 1415–1424.PubMedCrossRefGoogle Scholar
  322. Prato, V., Chiandussi, L., Massaro, A., Massa, U., and Zina, G. 1964. La porfiria cutanea tarda ereditaria. Minerva Med. 55, 1897–1905.PubMedGoogle Scholar
  323. Price, D. C, Epstein, J. H., Winchell, H. S., Sargent, T. W., Pollycove, M., and Cavalieri, R. R. 1968. Iron kinetics in porphyria cutanea tarda. Clin. Res. 16, 1–124.Google Scholar
  324. Quaglino, D., and Hayhoe, F. G. 1960. Periodic-acid-Schiff positivity in erythroblasts with special reference to Di Guglielmo’s disease. Brit. J. Haematol. 6, 26–33.CrossRefGoogle Scholar
  325. Raab, S. O., Haut, A., Cartwright, G. E., and Wintrobe, M. M. 1961. Pyridoxine-response anemia. Blood 18, 285–302.PubMedGoogle Scholar
  326. Rather, L. J. 1956. Hemochromatosis and hemosiderosis: Does iron overload cause diffuse fibrosis of the liver? Amer. J. Med. 21, 857–866.PubMedCrossRefGoogle Scholar
  327. Recommended Dietary Allowances, 8th ed. 1974. National Research Council, National Academy of Sciences, Washington, D. C.Google Scholar
  328. Reeves, G., Rigby, P. G., Rosen, H., Friedell, G. H., and Emerson, C. P. 1963. Hemochromatosis and congenital nonspherocytic hemolytic anemia in siblings. J. Amer. Med. Assoc. 186, 123–126.CrossRefGoogle Scholar
  329. Reimann, F., Fritsch, F., and Schick, K. 1937. Eisenbilanzversuche bei Gesunden und bei Anämischen. II. Untersuchungen über das Wesen der eisenempfindlichen Anämien (“Asiderosen”) und der therapeutischen Wirkung des Eisens bei diesen Anämien. Z. Klin. Med. 131, 1–50.Google Scholar
  330. Reimann, F., 1955. Wachstumsanomalien und Missbildungen bei Eisenmangelzuständen (Asiderosen). In: 5th Kongress der europäischen Gesellschaft für Hämatologie, Freiburg, pp. 546-550.Google Scholar
  331. Reynolds, R. D., Binder, H. J., Miller, M. B., Chang, W. W. Y., and Horan, S. 1968. Pagophagia and iron deficiency anemia. Ann. Intern. Med. 69, 435–440.PubMedCrossRefGoogle Scholar
  332. Richert, D. A., and Westerfeld, W. W. 1954. The relationship of iron to xanthine oxidase. J. Biol. Chem. 209, 179–189.PubMedGoogle Scholar
  333. Rimington, C. 1959. Biosynthesis of haemoglobin. Brit. Med. Bull. 15, 19–29.PubMedGoogle Scholar
  334. Roath, S., Bourne, M. S., and Israels, M. C. G. 1964. Ferrokinetics in pyridoxine-responsive anaemia. Acta Haematol. (Basel) 32, 1–8.CrossRefGoogle Scholar
  335. Rosselin, G. 1964. Ëtude ferrodynamique de l’hémochromatose primitive. Med. Monde 40, 107–115.PubMedGoogle Scholar
  336. Rothen, A. 1944. Ferritin and apoferritin in the ultracentrifuge: Studies on the relationship of ferritin and apoferritin; precision measurements of the rates of sedimentation of apoferritin. J. Biol. Chem. 152, 679–693.Google Scholar
  337. Rothstein, G., Lee, G. R., and Cartwright, G. E. 1969. Sideroblastic anemia with dermal photosensitivity and greatly increased erythrocyte protoporphyrin. N. Engl. J. Med. 280, 587–590.PubMedCrossRefGoogle Scholar
  338. Rous, P., and Oliver, J. 1918. Experimental hemochromatosis. J. Exp. Med. 28, 629–644.PubMedCrossRefGoogle Scholar
  339. Rundles, R. W., and Falls, H. F. 1946. Hereditary (?sex-linked)anemia. Amer. J. Med. Sci. N. Ser. 211, 641–658.CrossRefGoogle Scholar
  340. Rybo, G. 1966. Clinical and experimental studies on menstrual blood loss. Acta Obstet. Gynecol. Scand. 45, Suppl. 7, pp. 1–23.PubMedCrossRefGoogle Scholar
  341. Salmon, H. A. 1962. The cytochrome c content of the heart, kidney, liver, and skeletal muscle of iron-deficient rats. J. Physiol. (London) 164, 17–30.Google Scholar
  342. Saltzer, E. I., Redeker, A. G., and Wilson, J. W. 1968. Porphyria cutanea tarda: Remission following cloroquine administration without adverse effects. Arch. Dermatol. (Chicago) 98, 496–498.CrossRefGoogle Scholar
  343. Sargent, T., and Winchell, H. S. 1967. Iron absorption in hemochromatosis before and after therapy. Clin. Res. 15, 107 (abstract).Google Scholar
  344. Sauer, G. F., and Funk, D. D. 1969. Iron overload in cutaneous porphyria. Arch. Intern. Med. (Chicago) 124, 190–196.CrossRefGoogle Scholar
  345. Saunders, S. J. 1963. Iron metabolism in symptomatic porphyria: A preliminary communication. S. Afr. J. Lab. Clin. Med. 9, 277–282.Google Scholar
  346. Scandellari, C, Dobrilla, G., Bosello, O., Cavallini, G., Lo Cascio, V., and Cartei, G. 1967. Sulla validité délia ferrocinetica mediante Fe59 per la diagnosi differenziale tra siderocromatosi idiopatica e secondaria epatopatica. Acta Isot. (Padova) 7, 117–134.Google Scholar
  347. Schade, A. L., Reinhart, R. W., and Levy, H. 1949. Carbon dioxide and oxygen in complex formation with iron and siderophilin, the iron-binding component of human plasma. Arch. Biochem. 20, 170–172.PubMedGoogle Scholar
  348. Schaefer, J. W., Amick, C. J., Oikawa, Y., and Schiff, L. 1962. The development of hemochromatosis following portacaval anastomosis. Gastroenterology 42, 181–188.PubMedGoogle Scholar
  349. Schapira, G., Dreyfus, J.-C, Schwarzmann, V., and Étévé, J. 1962. Hypersidérémie et surcharge ferrique hépatique chez les decendents d’hémochromatosiques. Rev. Franc. Etud. Clin. Biol. 7, 485–491.PubMedGoogle Scholar
  350. Schmid, J. R., Oechslin, R. J., and Schnider, Th. 1964a. Ferrokinetische Untersuchungen bei primärer Hämochromatose und sideroachrestischer Anämie. Schweiz. Med. Wochenschr. 94, 1158–1164.PubMedGoogle Scholar
  351. Schmid, J. R., Oechslin, R. J., Schnider, Th., and Moeschlin, S. 1964b. Ein einfacher 6 stündiger i.m. Test mit Desferrioxamin-B (Desferal) zur Diagnose der Hämochromatose. Schweiz. Med. Wochenschr. 94, 1652.–1655.PubMedGoogle Scholar
  352. Schreiber, A. W. 1957. Hemochromatosis and the heart. Ann. Intern. Med. 47, 1015–1021.PubMedCrossRefGoogle Scholar
  353. Schubert, W. K., and Lahey, M. E. 1959. Copper and protein depletion complicating hypoferric anemia of infancy. Pediatrics 24, 710–733.PubMedGoogle Scholar
  354. Settlemire, C. T., and Matrone, G. 1967a. In vivo interference of zinc with ferritin iron in the rat. J. Nutr. 92, 153–158.PubMedGoogle Scholar
  355. Settlemire, C. T., and Matrone, G. 1967b. In vivo effect of zinc on iron turnover in rats and life span of the erythrocyte. J. Nutr. 92, 159–164.Google Scholar
  356. Shahidi, N. T. 1964. Anémie hypochrome par un trouble du métabolisme du fer. Schweiz. Med. Wochenschr. 94, 1385–1386.Google Scholar
  357. Shahidi, N. T., Nathan, D. G., and Diamond, L. K. 1964. Iron deficiency anemia associated with an error of iron metabolism in two siblings. J. Clin. Invest. 43, 510–521.PubMedCrossRefGoogle Scholar
  358. Sheldon, J. H. 1935. Haemochromatosis. Oxford University Press, London, pp. 1–382.Google Scholar
  359. Sherman, H. C. 1935. Chemistry of Food and Nutrition. Macmillan, New York, 640 pp.Google Scholar
  360. Shoden, A., and Sturgeon, P. 1959. Iron storage. II. The influence of the type of compound administered on the distribution of iron between ferritin and hemosiderin. Acta Haematol. 22, 140–145.PubMedCrossRefGoogle Scholar
  361. Shoden, A., and Sturgeon, P. 1960. Hemosiderin. I. A physico-chemical study. Acta Haematol. 23, 376–392.CrossRefGoogle Scholar
  362. Shoden, A., and Sturgeon, P. 1961. Formation of haemosiderin and its relation to ferritin. Nature (London) 189, 846–847.CrossRefGoogle Scholar
  363. Shoden, A., and Sturgeon, P. 1962. Iron storage, III. The influence of rates of administration of iron on its distribution between ferritin and hemosiderin. Acta Haematol. 27, 33–46.PubMedCrossRefGoogle Scholar
  364. Shoden, A., and Sturgeon, P. 1963. On the formation of haemosiderin and its relation to ferritin. II. A radioisotopic study. Brit. J. Haematol. 9, 513–522.CrossRefGoogle Scholar
  365. Siimes, M. A., Addiego, J. E., Jr. and Dallman, P. R. 1974. Ferritin in serum: Diagnosis of iron deficiency and iron overload in infants and children. Blood 43, 581–590.PubMedGoogle Scholar
  366. Sirivech, S., Frieden, E., and Osaki, S. 1974. The release of iron from horse spleen ferritin by reduced flavins. Biochem. J. 143, 311–315.PubMedGoogle Scholar
  367. Smith, H. D. 1964. Pédiatric lead poisoning. Arch Environ. Health (Chicago) 8, 256–261.CrossRefGoogle Scholar
  368. Smith, J. A., Drysdale, J. W., Goldberg, A., and Munroe, H. N. 1968. The effect of enterai and parenteral iron on ferritin syntehsis in the intestinal mucosa of the rat. Brit. J. Haematol. 14, 79–86.CrossRefGoogle Scholar
  369. Smith, P. M., Studley, F., and Williams, R. 1967. Assessment of body-iron stores in cirrhosis and haemochromatosis with the differential ferrioxamine test. Lancet 1, 133–136.PubMedCrossRefGoogle Scholar
  370. Smith, P. M., Lestas, A. N., Miller, J. P., Pitcher, C. S., Dymock, I. W., and Williams, R. 1969. The differential ferrioxamine test in the management of idiopathic haemochromatosis. Lancet 2, 402–405.PubMedCrossRefGoogle Scholar
  371. Soergel, K. H., and Sommers, S. C. 1962. Idiopathic pulmonary hemosiderosis and related syndromes. Amer. J. Med. 32, 499–511.CrossRefGoogle Scholar
  372. Spitzer, N., Newcomb, T. F., and Noyés, W. D. 1966. Pyridoxine-responsive hypolipidemia and hypocholesterolemia in a patient with pyridoxine-responsive anemia. TV. Engl. J. Med. 274, 772–775.CrossRefGoogle Scholar
  373. Srivastava, S. K., Sanwal, G. G., and Tewari, K. K. 1965. Biochemical alterations in rat tissue in iron deficiency anaemia and repletion with iron. Indian J. Biochem. 2, 257–266.PubMedGoogle Scholar
  374. Steiner, B., and Nabrady, J. 1965. Immunoallergic lung purpura treated with azathioprine. Lancet 1, 140–141.PubMedCrossRefGoogle Scholar
  375. Stevens, A. R., Jr., Coleman, D. H., and Finch, C. A. 1953. Iron metabolism: Clinical evaluation of iron stores. Ann. Intern. Med. 38, 199–205.PubMedCrossRefGoogle Scholar
  376. Stewart, W. B., Yuile, C. L., Clairborne, H. A., Snowman, R. T., and Whipple, G. H. 1950. Radioiron absorption in anemic dogs: Fluctuation in mucosal blocks and evidence for gradient of absorption in gastrointestinal tract. J. Exp. Med. 921, 375–382.CrossRefGoogle Scholar
  377. Stocks, A. E., and Martin, F. I. R. 1968. Pituitary function in haemochromatosis. Amer. J. Med. 45, 839–845.PubMedCrossRefGoogle Scholar
  378. Streeter, R. R., Presant, C. A., and Reinhard, E. 1977. Prognostic significance of thrombocytosis in idiopathic sideroblastic anemia. Blood 50, 427–432.PubMedGoogle Scholar
  379. Ströder, U. 1942. Infantilismus und Myokardfibrose bei der Hämochromatose. Dsch. Arch. Klin. Med. 189, 141–166.Google Scholar
  380. Sturgeon, P. 1956a. Studies in iron requirements in infants and children. II. The influence on normal infants of oral iron in therapeutic doses. Pediatrics 17, 341–348.PubMedGoogle Scholar
  381. Sturgeon, P. 1956b. Iron metabolism: A review with special consideration of iron requirements during normal infancy. Pediatrics 18, 267–298.PubMedGoogle Scholar
  382. Sturgeon, P. 1959. Studies of iron requirements in infants. III. Influence of supplemental iron during normal pregnancy on mother and infant. Brit. J. Haematol. 5, 31–44.CrossRefGoogle Scholar
  383. Swan, W. G. A., and Dewar, H. A. 1952. The heart in haemochromatosis. Brit. Heart J. 14, 117–124.PubMedCrossRefGoogle Scholar
  384. Swiss, L. D., and Beaton, G. H. 1974. A prediction of the effects of iron fortification. Am. J. Clin. Nutr. 27, 373–379.PubMedGoogle Scholar
  385. Synderman, S. E., Holt, L. E., Jr., Carretero, R., and Jacobs, K. 1953. Pyridoxine deficiency in the human infant. J. Clin. Nutr. 1, 200–207.Google Scholar
  386. Tisdale, W. A. 1961. Parenchymal siderosis in patients with cirrhosis after portasystemic-shunt surgery. TV. Engl. J. Med. 265, 928–932.CrossRefGoogle Scholar
  387. Tranchida, L., Palutke, M., Poulik, M. D., and Prasad, A. S. 1973. Primary acquired sideroblastic anemia preceding monoclonal gammopathy and malignant lymphoma. Amer. J. Med. 55, 559–564.PubMedCrossRefGoogle Scholar
  388. Tuffanelli, D. L. 1960. Porphyria cutanea tarda associated with hemochromatosis. U.S. Armed Forces Med. J. 11, 1210–1216.PubMedGoogle Scholar
  389. Tuppy, H., and Paléus, S. 1955. A peptic degradation product of cytochrome c. I. Purification and chemical composition. Acta Chem. Scand. 9, 353–364.CrossRefGoogle Scholar
  390. Turnberg, L. A. 1965. Excessive oral iron therapy causing haemochromatosis. Brit. Med. J. 1, 1360.PubMedCrossRefGoogle Scholar
  391. Tuttle, S. G., Figueroa, W. G., and Grossman, M. I. 1959. Development of hemochromatosis in a patient with Laennec’s cirrhosis. Amer. J. Med. 26, 655–658.PubMedCrossRefGoogle Scholar
  392. Udenfriend, S. 1970. Biosynthesis of hydroxyproline in collagen. In: Chemistry and Molecular Biology of the Intercellular Matrix, Vol. (E. A. Balezs, ed.). Academic Press, New York, pp. 371–384.Google Scholar
  393. Ulstrom, R. A., Smith, N. J., and Heinlich, E. M. 1956. Transient dysproteinemia in infants: A new syndrome. I. Clinical studies. Am. J. Dis. Child. 92, 219–253.Google Scholar
  394. Underwood, E. J. 1977. Trace Elements in Human and Animal Nutrition, 4th ed. Academic Press, New York, pp. 13–55.Google Scholar
  395. Vahlquist, B. C. 1941. Das Serumeisen-eine pädiatrischklinische und experimentelle Studie. Acta Paediatr. (Suppl. 5) 28, 1–374.CrossRefGoogle Scholar
  396. Vahlquist, B. 1950. The cause of the sexual differences in erythrocyte, hemoglobin and serum iron levels in human adults. Blood 5, 874–875.PubMedGoogle Scholar
  397. Van Campen, D. and Gross, E. 1969. Effect of histidine and certain other amino acids on the absorption of iron-59 by rats. J. Nutr. 99, 68–74.PubMedGoogle Scholar
  398. Vavra, S. D., and Poff, S. A. 1967. Heme and porphyrin synthesis in sideroblastic anemia. J. Lab. Clin. Med. 69, 904–918.PubMedGoogle Scholar
  399. Vavra, J. D., Mayer, V. K., and Moore, C. V. 1964. In vitro heme synthesis by human blood: Abnormal heme synthesis in thalassemia major. J. Lab. Clin. Med. 63, 736–753.PubMedGoogle Scholar
  400. Velez, H., Restrepo, A., Vitale, J. J., and Hellerstein, E. E. 1966. Folic acid deficiency secondary to iron deficiency in man: Remission with iron therapy and a diet low in folic acid. Amer. J. Clin. Nutr. 19, 27–36.PubMedGoogle Scholar
  401. Verloop, M. C, and Rademaker, W. 1960. Anaemia due to pyridoxine deficiency in man. Brit. J. Haematol. 6, 66–80.CrossRefGoogle Scholar
  402. Verloop, M. C, Panders, J. T., Ploem, J. E., and Bos, C. C. 1964. Sideroachrestic anaemias. In: International Society of Haematology, 10th Congress, Stockholm, Vol. 5-6. Ejnar Munksgaards Forlag, Copenhagen, pp. 76–87.Google Scholar
  403. Vilter, R. W., Mueller, J. F., Glazer, H. S., Jarrold, T., Abraham, J., Thompson, C, and Hawkins, V. R. 1953. The effect of vitamin B6 deficiency induced by desoxypyridoxine in human beings. J. Lab. Clin. Med. 42, 335–357.PubMedGoogle Scholar
  404. Vinson, P. P. 1922. Hysterical dysphagia. Minn. Med. 5, 107–108.Google Scholar
  405. Vogler, W. R., and Mingioli, E. S. 1965. Heme synthesis in pyridoxine-responsive anemia. N. Engl. J. Med. 273, 347–353.PubMedCrossRefGoogle Scholar
  406. Vogler, W. R., and Mingioli, E. S. 1968. Porphyrin synthesis and heme synthetase activity in pyridoxine-responsive anemia. Blood 32, 979–988.PubMedGoogle Scholar
  407. Vuylsteke, J., Verloop, M. C, and Drogendijk, A. C. 1961. Favorable effect of pyridoxine and ascorbic acid in a patient with refractory sideroblastic anaemia and haemochromatosis. Acta Med. Scand. 169, 113–123.PubMedCrossRefGoogle Scholar
  408. Wallerstein, R. O., and Robbins, S. L. 1953. Hemochromatosis after prolonged oral iron therapy in a patient with chronic hemolytic anemia. Amer. J. Med. 14, 256–260.PubMedCrossRefGoogle Scholar
  409. Walsh, J. R., Kaldor, I., Brading, I., and George, E. P. 1955. The availability of iron in meat: Some experiments with radioactive iron. Aust. Ann. Med. 4, 272–276.PubMedGoogle Scholar
  410. Walsh, J. R., Perkins, K. W., Blackburn, C. R., Sanford, R., and Cantrill, S. 1963. The use of DTPA in the diagnosis and management of idiopathic haemochromatosis. Aust. Ann. Med. 12, 192–196.PubMedGoogle Scholar
  411. Walsh, J. R., Mass, R. E., Smith, F. W., and Lange, V. 1965. Iron chelation with deferoxamine in hepatic disease. Gastroenterology 49, 134–140.PubMedGoogle Scholar
  412. Warembourg, H., Niquet, G., Ducloux, G., and Théry, C. 1965. Adiastolie par péricardite constrictive et hémochromatose. Little Med. 10, 599–604.Google Scholar
  413. Wasserman, A. J., Richardson, D. W., Baird, C. L., and Wyso, E. M. 1962. Cardiac hemochromatosis simulating constrictive pericarditis. Amer. J. Med. 32, 316–323.PubMedCrossRefGoogle Scholar
  414. Weatherall, D. J., Pembrey, M. E., Hall, E. G. Sänger, R., Tippett, P., and Glavin, J. 1970. Familial sideroblastic anemia: Problem of Xg and X chromosome inactivation. Lancet 2, 744–748.PubMedCrossRefGoogle Scholar
  415. Weintraub, L. R., Conrad, M. E., and Crosby, W. H. 1964. The role of hepatic iron stores in the control of iron absorption. J. Clin. Invest. 43, 40–44.PubMedCrossRefGoogle Scholar
  416. Weintraub, L. R., Conrad, M. E., and Crosby, W. H. 1965. Regulation of the intestinal absorption of iron by the rate of erythropoiesis. Brit. J. Haematol. 11, 432–438.CrossRefGoogle Scholar
  417. Weintraub, L. R., Weinstein, M. B., Huser, H., and Rafal, S. 1968. Absorption of hemoglobin iron: The role of a heme-splitting substance in the intestinal mucosa. J. Clin. Invest. 47, 531–539.PubMedCrossRefGoogle Scholar
  418. Weiss, E. B., Earnest, D. L., and Greally, J. F. 1968. Goodpasture’s syndrome: Case report with emphasis on pulmonary physiology. Amer. Rev. Respir. Dis. 97, 444–450.Google Scholar
  419. Wheby, M. S., and Crosby, W. H. 1963. The gastrointestinal tract and iron absorption. Blood 22, 416–428.PubMedGoogle Scholar
  420. Whipple, G. H., and Robscheit-Robbins, F. S. 1925. Blood regeneration in severe anemia. Amer. J. Physiol. 72, 395–435.Google Scholar
  421. W.H.O. Health Bulletin No. 23. 1951. Government of India Press, New Delhi.Google Scholar
  422. Williams, D. M., Loukopoulos, D., Lee, G. R., and Cartwright, G. E. 1976. Role of copper in mitochondrial iron metabolism. Blood 48, 77–85.PubMedGoogle Scholar
  423. Williams, R., Smith, P. M., Spicer, E. J. F., Barry, M., and Sherlock, S. 1969. Venesection therapy in idiopathic haemochromatosis: An analysis of 40 treated and 18 untreated patients. Q. J. Med. 38, 1–16.PubMedGoogle Scholar
  424. Wilson, J. D., Scott, P. J., and North, J. D. K. 1967. Hemochromatosis in association with hereditary spherocytosis. Arch. Intern. Med. (Chicago) 120, 701–707.CrossRefGoogle Scholar
  425. Wilson, J. F., Heiner, D. C, and Lahey, M. E. 1962. Studies on iron from metabolism. I. Evidence of gastrointestinal dysfunction in infants with iron deficiency anemia. A preliminary report. J. Pediatr. 60, 787–800.PubMedCrossRefGoogle Scholar
  426. Wintrobe, M. M., and Beebe, R. T. 1933. Idiopathic hypochromic anemia. Medicine (Baltimore) 12, 187–243.Google Scholar
  427. Wöhler, F. 1964. Diagnosis of iron storage diseases with desferrioxamine (Desferal test). Acta Haematol. (Basel) 32, 321–337.CrossRefGoogle Scholar
  428. Worwood, M. 1977. The clinical biochemistry of iron. Semin. Hematol. 14, 3–30.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Ananda Shiva Prasad
    • 1
    • 2
  1. 1.School of Medicine and Department of Medicine, Harper-Grace HospitalWayne State UniversityDetroitUSA
  2. 2.Veterans Administration HospitalAllen ParkUSA

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