The ancient Greeks used burnt sponges empirically in the treatment of human goiter. This knowledge led the French physician Coindet to use iodine salts for the treatment of goiter (Coindet, 1820). A systematic investigation of this concept was undertaken by Chatin, between the years 1850 and 1876 (Chatin, 1850–1854). He determined the natural occurrence of iodine in air, water, soils, and foods from various localities and compared his results with the incidence of goiter. Chatin concluded that the occurrence of goiter was associated with a deficiency of environmental iodine and recommended that the water supply in goitrous districts be enriched with this element.
KeywordsThyroid Hormone Iodine Deficiency Iodine Content Endemic Goiter Thyroid Hormone Action
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