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Chromium

  • Chapter
Trace Elements and Iron in Human Metabolism

Part of the book series: Topics in Hematology ((TOHE))

Abstract

In 1957, Schwarz and Mertz (1957) observed impaired glucose tolerance in rats fed certain diets and postulated that the condition was due to a deficiency of a new dietary agent, designated the glucose tolerance factor (GTF). Later, it was shown that chromium is an integral and active part of GTF, the exact structure of which is not well understood, but is believed to contain two nicotinic acid molecules per chromium atom and possibly contains cysteine, glycine, and even glutamic acid residues.

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References

  • Arenas, J. M. 1970. Poisoning: Toxicology—Symptoms—Treatments, 2nd ed. Charles C. Thomas, Springfield, Illinois, p. 198.

    Google Scholar 

  • Brinton, H. P., Fraiser, E.S., and Koven, A.L. 1952. Morbidity and mortality experiences among chromate workers; respiratory cancer and other causes. Public Health Rep. 67, 835–847.

    Article  PubMed  CAS  Google Scholar 

  • Burt, R. L., and Davidson, I.W.F. 1973. Carbohydrate metabolism in pregnancy: A possible role of chromium. Acta Diabetol. Lat. 10, 770–778.

    Article  PubMed  CAS  Google Scholar 

  • Carter, J. P., Kattob, A., Abd-El-Hodi, Davis, J.T., El Cholmy, A., and Patwardhan, V.N. 1968. Chromium III in hypoglycemia and in impaired glucose utilization in kwashiorkor. Amer. J. Clin. Nutr. 21, 195–202.

    PubMed  CAS  Google Scholar 

  • Curran, G. L. 1954. Effect of certain transition group elements on hepatic synthesis of cholesterol in the rat. J. Biol. Chem. 210, 765–770.

    PubMed  CAS  Google Scholar 

  • Czerniejewski, C. P., Shank, C.W., Bechtel, W.G., and Bradley, W.B. 1964. The minerals of wheat, flour, and bread. Cereal Chem. 41, 65–72.

    Google Scholar 

  • Davidson, I. W. F., and Blackwell, W. L. 1968. Changes in carbohydrate metabolism of squirrel monkeys with chromium dietary supplementation. Proc. Soc. Exp. Biol. Med. 127, 66–72.

    PubMed  CAS  Google Scholar 

  • Davidson, I. W. F., and Burt, R. L. 1973. Physiologic changes in plasma chromium of normal and pregnant women: Effect of glucose load. Amer. J. Obstet. Gynecol. 116, 601–608.

    CAS  Google Scholar 

  • Davidson, I. W. F., and Secrest, W. L. 1972. Determination of chromium in biological materials by atomic absorption spectrometry using a graphite furnace atomizer. Anal. Chem. 44, 1808–1813.

    Article  PubMed  CAS  Google Scholar 

  • Davidson, I. W. F., Lang, C. M., and Blackwell, W. L. 1967. Impairment of carbohydrate metabolism of the squirrel monkey. Diabetes 16, 395–401.

    PubMed  CAS  Google Scholar 

  • Doisy, R. J. 1963. Plasma insulin assay and adipose tissue metabolism. Endocrinology 72, 273–278.

    Article  PubMed  CAS  Google Scholar 

  • Doisy, R. J., Streeten, D. H. P., Levine, R. A., and Chodos, R. B. 1968. Effects and metabolism of chromium in normals, elderly subjects, and diabetics. In: Trace Substances in Environmental Health, Vol. II (D.D. Hemphill, ed.). University of Missouri Press, Columbia, pp. 75–82.

    Google Scholar 

  • Doisy, R. J., Streeten, D. H. P., Souma, M. L., Kalafer, M. E., Rekant, S. I., and Dalakos, T. G. 1971. Metabolism of 51chromium in human subjects—normal, elderly, and diabetic subjects. In: Newer Trace Elements in Nutrition (W. Mertz and W. E. Cornatzer, eds.). Dekker, New York, pp. 155–168.

    Google Scholar 

  • Doisy, R. J., Jastremski, M. S., and Greenstein, F. L. 1973. Metabolic effects of glucose tolerance factor and trivalent chromium in normal and genetically diabetic mice. Excerpta Med. Found. Int. Congr. Ser. 280, 155 (abstract).

    Google Scholar 

  • Doisy, R. J., Streeten, D. H. P., Freiberg, J. M., and Schneider, A. J. 1976. Chromium metabolism in man and biochemical effects. In: Trace Elements in Human Health and Disease, Vol. II (A.S. Prasad, ed.). Academic Press, New York, pp. 79–104.

    Google Scholar 

  • Donaldson, R. M., and Barreras, R. F. 1966. Intestinal absorption of trace quantities of chromium. J. Lab. Clin. Med. 68, 484–493.

    PubMed  CAS  Google Scholar 

  • Durfor, C. N., and Becker, E. 1964. Public water supplies of the 100 largest cities in the United States, 1962. U.S. Government Printing Office, Washington, D.C. Geological Survey Water Supply Paper 1812.

    Google Scholar 

  • Glinsmann, W. H., and Mertz, W. 1966. Effect of trivalent chromium on glucose tolerance. Metab. Clin Exp. 15, 510–520.

    Article  PubMed  CAS  Google Scholar 

  • Glinsmann, W. H., Feldman, F. J., and Mertz, W. 1966. Plasma chromium after glucose administration. Science 152, 1243–1245.

    Article  PubMed  CAS  Google Scholar 

  • Gormican, A. 1970. Inorganic elements in foods used in hospital menus. J. Amer. Diet. Assoc. 56, 397–403.

    CAS  Google Scholar 

  • Gürson, C.T., and Saner, G. 1971. Effect of chromium on glucose utilization in marasmic protein-calorie malnutrition. Amer. J. Clin. Nutr. 24, 1313–1319.

    PubMed  Google Scholar 

  • Gürson, C. T., and Saner, G. 1973. Effect of chromium supplementation on growth in marasmic protein-calorie malnutrition. Amer. J. Clin. Nutr. 26, 988–991.

    PubMed  Google Scholar 

  • Hambidge, K. M. 1971. Chromium nutrition in the mother and the growing child. In: Newer Trace Elements in Nutrition, Proceedings of an International Symposium (W. Mertz and W. E. Cornatzer, eds.). Dekker, New York, Chapt. 9, pp. 169–194.

    Google Scholar 

  • Hambidge, K. M. 1974. Chromium nutrition in man. Amer. J. Clin. Nutr. 27, 505–514.

    PubMed  CAS  Google Scholar 

  • Hambidge, K. M., and Baum, J. D. 1972. Hair chromium concentrations of human newborn and changes during infancy. Amer. J. Clin. Nutr. 25, 376–379.

    PubMed  CAS  Google Scholar 

  • Hambidge, K. M., Rodgerson, D. O., and O’Brien, D. 1968. The concentration of chromium in the hair of normal and children with juvenile diabetes mellitus. Diabetes 17, 517–519.

    PubMed  CAS  Google Scholar 

  • Hopkins, L. L., Jr., and Price, M. G. 1968. Effectiveness of Chromium III in improving the impaired glucose tolerance of middle-aged Americans. In: Proceedings of the 2nd Western Hemisphere Nutrition Congress, 1968, Vol. 2, pp. 40–41 (abstract).

    Google Scholar 

  • Hopkins, L. L., Jr., and Schwarz, K. 1964. Chromium binding to serum proteins, specifically siderophilin. Biochim. Biophys. Acta 90, 484–491.

    Article  PubMed  CAS  Google Scholar 

  • Hopkins, L. L., Jr., Ransome-Kuti, O., and Majaj, A. S. 1968. Improvement of impaired carbohydrate metabolism by Chromium III in malnourished infants. Amer. J. Clin. Nutr. 21, 203–211.

    PubMed  CAS  Google Scholar 

  • Jeejeebhoy, K. N., Chu, R. C., Marliss, E. B., Greenberg, G. R., and Robertson, A. B. 1977. Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition. Amer. J. Clin. Nutr. 30, 531–538.

    PubMed  CAS  Google Scholar 

  • Levine, R. A., Streeten, D. H.P., and Doisy, R. J. 1968. Effects of oral chromium supplementation on the glucose tolerance of elderly human subjects. Metab. Clin. Exp. 17, 114–125.

    Article  PubMed  CAS  Google Scholar 

  • MacKenzie, R. D., Byerrum, R. U., Decker, C. F., Hoppert, C. A., and Langham, R. F. 1958. Chronic toxicity studies. II. Hexavalent and trivalent chromium administered in drinking water to rats. AMA Arch. Ind. Health 18, 232–234.

    PubMed  CAS  Google Scholar 

  • Maxia, V., Melini, S., Rollier, M. A., Brandone, A., Patwardhan, V. N., Waslien, C. I., and Said-El-Shami. 1972. Selenium and chromium assay in Egyptian foods and blood of Egyptian children by activation analysis. In: Nuclear Activation Techniques in the Life Sciences. IAEA-SM 157/67, IAEA, Vienna, pp. 527–550.

    Google Scholar 

  • McCay, C. M. 1952. Chemical aspects of aging and the effect of diet upon aging. In: Cowdry’s Problems of Aging, 3rd ed. (A.J. Lansing, ed.). Williams & Wilkins, Baltimore, Chapt. 6, pp. 139–202.

    Google Scholar 

  • Mertz, W. 1967. Biological role of chromium. Fed. Proc. Fed. Am. Soc. Exp. Biol. 26, 186–193.

    CAS  Google Scholar 

  • Mertz, W. 1969. Chromium occurrence and function in biological systems. Physiol. Rev. 49, 169–239.

    Google Scholar 

  • Mertz, W. 1971. Human requirements: Basic and optimal. Ann. N. Y. Acad. Sci. 199, 191–199.

    Article  Google Scholar 

  • Mertz, W. 1974. Biological function of chromium-nicotinic acid complexes. Fed. Proc. Fed. Am. Soc. Exp. Biol. 33, 659 (abstract).

    Google Scholar 

  • Mertz, W., and Roginski, E. E. 1971. Chromium metabolism: Glucose tolerance factor. In: Newer Trace Elements in Nutrition, Proceedings of an International Symposium (W. Mertz and W. E. Cornatzer, eds.). Dekker, New York, Chapt. 7, pp. 123–153.

    Google Scholar 

  • Mertz, W., and Schwarz, K. 1959. Relation of glucose tolerance factor to impaired glucose tolerance in rats on stock diets. Amer. J. Physiol. 196, 614–618.

    PubMed  CAS  Google Scholar 

  • Mertz, W., Roginski, E, E., and Reba, R. 1965. Biological activities and fate of trace quantities of intravenous chromium (3) in the rat. Amer. J. Physiol. 209, 489–494.

    PubMed  CAS  Google Scholar 

  • Morgan, J. M. 1972. Hepatic chromium content in diabetic subjects. Metab. Clin. Exp. 21, 313–316.

    Article  PubMed  CAS  Google Scholar 

  • Pekarek, R. S., Hauer, E. C., Wannemacher, R. W., Jr., and Beisel, W. R. 1973a. Serum chromium concentrations and glucose utilization in healthy and infected subjects. Fed. Proc. Fed. Am. Soc. Exp. Biol. 32, 930 (abstract).

    Google Scholar 

  • Pekarek, R. S., Hauer, E. C., Wannemacher, R. W., Jr., and Beisel, W. R. 1973b. The direct determination of serum chromium by an atomic absorption spectrophotometer with heated graphite atomizer. Anal. Biochem. 59, 283–292.

    Article  Google Scholar 

  • Schroeder, H. A. 1968. The role of chromium in mammalian nutrition. Amer. J. Clin. Nutr. 21, 230–244.

    PubMed  CAS  Google Scholar 

  • Schroeder, H. A. 1971. Losses of vitamin and trace minerals resulting from processing and preservation of foods. Amer. J. Clin. Nutr. 24, 562–573.

    PubMed  CAS  Google Scholar 

  • Schroeder, H. A., and Balassa, J. J. 1965. Influence of chromium, cadmium, and lead on rat aortic lipids and circulating cholesterol. Amer. J. Physiol. 209, 433–437.

    PubMed  CAS  Google Scholar 

  • Schroeder, H. A., Balassa, J. J., and Tipton, I. H. 1962. Abnormal trace metal in man: Chromium. J. Chronic Dis. 15, 941–964.

    Article  PubMed  CAS  Google Scholar 

  • Schroeder, H. A., Balassa, J. J., and Vinton, W. H., Jr. 1965. Chromium, cadmium and lead in rats: Effects on life span, tumors, and tissue levels. J. Nutr. 86, 51–66.

    PubMed  CAS  Google Scholar 

  • Schroeder, H. A., Nason, A. P., and Tipton, I. H. 1970. Chromium deficiency as a factor in atherosclerosis. J. Chronic Dis. 23, 123–142.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, K., and Mertz, W. 1957. A glucose tolerance factor and its differentiation from factor 3. Arch. Biochem. Biophys. 72, 515–518.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, K., and Mertz, W. 1959. Chromium III and the glucose tolerance factor. Arch. Biochem. Biophys. 85, 292–295.

    Article  PubMed  CAS  Google Scholar 

  • Staub, H. W., Reussner, G., and Thiessen, R. T., Jr. 1969. Serum cholesterol reduction by chromium in hypercholesterolemic rats. Science 166, 746–747.

    Article  PubMed  CAS  Google Scholar 

  • Toepfer, E. W., Mertz, W., Roginski, E. E., and Polansky, M. M. 1973. Chromium in foods in relation to biological activity. J. Agric. Food Chem. 21, 69–73.

    Article  PubMed  CAS  Google Scholar 

  • Wacker, W. E. C., and Vallee, B. L. 1959. Nucleic acids and metals. I. Chromium, manganese, nickel, iron, and other metals in ribonucleic acid from diverse biological sources. J. Biol. Chem. 234, 3257–3262.

    CAS  Google Scholar 

  • Wolf, W., Greene, F. E., and Mitman, F. W. 1974. Determination of urinary chromium by low temperature ashing-flameless atomic absorption. Fed. Proc. Fed. Am. Soc. Exp. Biol. 33, 659 (abstract).

    Google Scholar 

  • Yalow, R. S., and Berson, S. A. 1960. Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39, 1157–1175.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Medicine and Department of Medicine, Harper-Grace Hospital, Wayne State University, Detroit, Michigan, USA

    Ananda Shiva Prasad M.D., Ph.D.

  2. Veterans Administration Hospital, Allen Park, Michigan, USA

    Ananda Shiva Prasad M.D., Ph.D.

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  1. Ananda Shiva Prasad M.D., Ph.D.
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Prasad, A.S. (1978). Chromium. In: Trace Elements and Iron in Human Metabolism. Topics in Hematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0793-8_1

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  • DOI: https://doi.org/10.1007/978-1-4684-0793-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-0795-2

  • Online ISBN: 978-1-4684-0793-8

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