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A Comparison of the Effect of Lithium Aid Haloperidol on Human Peripheral β-Adrenergic Adenylate Cyclase

  • Richard P. Ebstein
  • Robert H. Belmaker

Abstract

Lithium (Li) is an effective therapy in the treatment and prevention of the manic phase of manic-depressive illness (1). Lithium influences a number of physiological systems including biogenic amines (2,3), membrane transport (4–6), amino acid metabolism (7,8) protein synthesis (9–11), endocrine secretion (12) and some kinds of behaviour (13–15). Although the involvement of Li in cellular processes appears to be ubiquitous, no specific mechanism has been identified for Li’s therapeutic efficacy in manic-depressive illness.

Keywords

Adenylate Cyclase Adenylate Cyclase Activity Epinephrine Injection Epinephrine Administration Stimulate Adenylate Cyclase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Richard P. Ebstein
    • 1
  • Robert H. Belmaker
    • 1
  1. 1.The Jerusalem Mental Health CenterJerusalemIsrael

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