The Significance of the Cerebral Dopamine Metabolism in the Pathogenesis and Treatment of Psychotic Disorders

  • H. M. van Praag


For many years, well into the Sixties, research into the biological determinants of schizophrenic psychoses has suffered from a dearth of more or less well-founded and testable working hypotheses. Without much system, efforts were made to find abnormal metabolites in a wide variety of body fluids. Strange people, strange substances: not a very powerful research strategy. It has recently dawned, however, that neuroleptics could serve as the pacemaker of biological psychosis research (Matthysse 1973; Snyder, 1974; van Praag 1975), much as the antidepressants are the pacemaker of biological depression research (Van Praag 1976a). I shall briefly discuss the arguments which have led to this conclusion.


Psychotic Disorder Fusaric Acid Serum Prolactin Level Neuroleptic Medication Schizophrenic Psychos 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • H. M. van Praag
    • 1
  1. 1.Department of Biological PsychiatryState University GröningenThe Netherlands

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