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Abstract

The rapid advance of diagnostic and therapeutic technology has led to a shift in the emphasis of research in perinatal mineral metabolism. Whereas the initial focus of investigation was aimed at the gross composition of the fetus and neonate, more recently the focus has shifted to physiological control and presently to subcellular control.1,2 Although the understanding is far from complete, there is a greater appreciation of the complex interrelations among the major mineral components of bone (calcium, phosphorus, and magnesium) and their recognized major hormonal regulators (parathyroid hormone, vitamin D, and calcitonin). The purpose of this chapter is to review the physiological basis of bone mineral metabolism in continuity from fetus to neonate. Each section begins with an overview of basic physiology, followed by a section on the impact of pregnancy including placental-fetal physiology, and ends with the dynamic period of the neonate.

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References

  1. Givens MH, Macy IG. The chemical composition of the human fetus. J Biol Chem 1933;102:7–17.

    CAS  Google Scholar 

  2. Widdowsen EM, Spray CM. Chemical development. Arch Dis Child 1951;26:205–214.

    Google Scholar 

  3. Heaney RP, Saville PD, Recker RR. Calcium absorption as a function of calcium intake. J Lab Clin Med 1975;85:881–890.

    PubMed  CAS  Google Scholar 

  4. Davis RH, Morgan DB, Rivlin RS. The excretion of calcium in the urine and its relation to calcium intake, sex and age. Clin Sci 1970;39:1–12.

    PubMed  CAS  Google Scholar 

  5. Bulusu L, Hodgkinson A, Nordin BEC, et al. Urinary excretion of calcium and creatinine in relation to age and body weight in normal subjects and patients with renal calculus. Clin Sci 1970;38:601–612.

    PubMed  CAS  Google Scholar 

  6. Heaney RP, Skillman TG. Calcium metabolism in normal human pregnancy. J Clin Endocrinol Metab 1971;33:881–890.

    Google Scholar 

  7. Bouillon R, Van Assche FA, van Baelen H, et al. Influence of the vitamin D-binding protein in the serum concentration of 1,25-D-hydroxyvitamin D3. J Clin Invest 1981;67:589–596.

    PubMed  CAS  Google Scholar 

  8. Howarth AT, Morgan DB, Payne RB. Urinary excretion of calcium in late pregnancy and its relation to creatinine clearance. Am J Obstet Gynecol 1977;129:499–502.

    PubMed  CAS  Google Scholar 

  9. Duggin GG, Lyneham RC, Dale NE, et al. Calcium balance in pregnancy. Lancet 1974;2:926–927.

    PubMed  CAS  Google Scholar 

  10. Pitkin RM, Reynolds WA, Williams GA, et al. Calcium metabolism in normal pregnancy: a longitudinal study. Am J Obstet Gynecol 1979;133:781–790.

    PubMed  CAS  Google Scholar 

  11. Reitz RE, Daane TA, Woods JR, et al. Calcium, magnesium, phosphorus, and parathyroid hormone interrelationships in pregnancy and newborn infant. Obstet Gynecol 1977;50:701–705.

    PubMed  CAS  Google Scholar 

  12. Pecher C, Pecher J. Radio-calcium and radiostrontium metabolism in pregnant mice. Proc Soc Exp Biol Med 1941;46:91–94.

    CAS  Google Scholar 

  13. Christiansen C, Rodbro P, Heinild B. Unchanged total body calcium in normal human pregnancy. Acta Obstet Gynecol Scand 1976;55:141–143.

    PubMed  CAS  Google Scholar 

  14. Walker ARP, Richardson B, Walker F. The influence of numerous pregnancies and lactations on bone dimensions in South African, Bantu, and Caucasian mothers. Clin Sci 1972;42:189–195.

    PubMed  CAS  Google Scholar 

  15. Whitsett JA, Tsang RC. Calcium uptake and binding by membrane fractions of human placenta. Pediatr Res 1980;14:769–775.

    PubMed  CAS  Google Scholar 

  16. Fisher GJ, Kelley LK, Smith CH. ATP-dependent calcium transport across basal plasma membranes of human placental trophoblast. Am J Physiol 1987;252: C38–C46.

    PubMed  CAS  Google Scholar 

  17. Booher LE, Hansmann GH. Studies in the clinical composition of the human skeleton. I. Calcification of the tibia of the normal newborn infant. J Biol Chem 1931;94:195–205.

    CAS  Google Scholar 

  18. Umeki S, Nagao S, Nozawa Y. The purification and identification of calmodulin from human placenta. Biochim Biophys Acta 1981;674:319–326.

    PubMed  CAS  Google Scholar 

  19. Bruns ME, Fausto A, Avioli LV. Placental calcium binding proteins in rats: apparent identity with vitamin D-dependent calcium binding protein from rat intestine. J Biol Chem 1978;253:3186–3190.

    PubMed  CAS  Google Scholar 

  20. Bruns ME, Kleeman E, Mills SE, et al. Immunochemical localization of vitamin D-dependent calcium binding protein in mouse placenta and yolk sac. Anat Rec 1985;213:514–517.

    PubMed  CAS  Google Scholar 

  21. Lester GE. Cholecalciterol and placental calcium transport. Fed Proc 1986;45:2524–2527.

    PubMed  CAS  Google Scholar 

  22. Tanaka Y, Halloran B, Schnoes HK, et al. In vitro production of 1,25-dihydroxyvitamin D3 by rat placental tissue. Proc Natl Acad Sci USA 1979;76: 5033–5035.

    PubMed  CAS  Google Scholar 

  23. Weisman Y, Harell A, Edelstein S, et al. 1,25-Dihy-droxyvitamin D3 and 24,25-dihydroxyvitamin D in vitro synthesis by human decidua and placenta. Nature 1979;281:317–319.

    PubMed  CAS  Google Scholar 

  24. Rodda CP, Kubota M, Heath JA, et al. Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcemia of malignancy. J Endocrinol 1988;117: 261–271.

    PubMed  CAS  Google Scholar 

  25. Care AD, Caple IW, Abbas SK, et al. The roles of the parathyroid and thyroid glands on calcium homeostasis in the ovine fetus. In Jones CT, Nathanielson PW, eds. The Physiological Development of the Fetus and Newborn. London: Academic Press, 1985;135–145.

    Google Scholar 

  26. Widdowsen EM, Dickerson JWT. Chemical composition of the body. In Comar CL, Brunner F, eds: Mineral Metabolism. Vol. 2. Orlando: Academic Press, 1961.

    Google Scholar 

  27. Kelly HJ, Sloan RE, Hoffman W, et al. Accumulation of nitrogen and 6 minerals in the human foetus during gestation. Hum Biol 1951;23:61–74.

    PubMed  CAS  Google Scholar 

  28. Shaw JCL. Evidence for defective skeletal mineralization in low birthweight infants;the absorption of calcium and fat. Pediatrics 1976;57:16–25.

    PubMed  CAS  Google Scholar 

  29. Pitkin RM, Calcium metabolism in pregnancy: a review. Am J Obstet Gynecol 1975;121:724–737.

    PubMed  CAS  Google Scholar 

  30. Loughead JL, Mimouni F, Tsang RC. Serum ionized calcium concentrations in normal neonates. Am J Dis Child 1988;142:516–518.

    PubMed  CAS  Google Scholar 

  31. Wandrup J, Kancir C, Norgaard-Pedersen B. The concentration of free calcium ions in capillary blood from neonates on a routine basis using ICA2. Scand J Clin Lab Invest 1984;44:19–24.

    PubMed  CAS  Google Scholar 

  32. Okamoto E, Muttart C, Zucker C, et al. Use of medium chain triglycerides in feeding the low-birth-weight infant. Am J Dis Child 1982;136:428–431.

    PubMed  CAS  Google Scholar 

  33. Tantibhedhyangkul P, Hashim S. Medium chain triglycerides feeding in premature infants: effects on calcium and magnesium absorption. Pediatrics 1978;61:537–545.

    PubMed  CAS  Google Scholar 

  34. Giles MM, Fenton MH, Shaw B, et al. Sequential calcium and phosphorus balance studies in preterm infants. J Pediatr 1987;110:591–598.

    PubMed  CAS  Google Scholar 

  35. Hillman LS, Tack E, Covell DG, et al. Measurement of true calcium absorption in premature infants using intravenous 46Ca and oral 44Ca. Pediatr Res 1988;23: 589–594.

    PubMed  CAS  Google Scholar 

  36. Barltrop D, Mole RH, Sutton A. Absorption and endogenous faecal excretion of calcium by low birth-weight infants on feeds with varying contents of calcium and phosphate. Arch Dis Child 1977;52:41–49.

    PubMed  CAS  Google Scholar 

  37. Senterre J, Salle B. Calcium and phosphorus economy of the preterm infant and its interaction with vitamin D and its metabolites. Acta Pediatr Scand [Suppl] 1982;296:85–92.

    CAS  Google Scholar 

  38. Siegel SR, Hadeed A. Renal handling of calcium in the early newborn period. Kidney Int 1987;31:1181–1185.

    PubMed  CAS  Google Scholar 

  39. Schanler RJ, Oh W. Composition of breast milk obtained from mothers of premature infants as compared to breast milk obtained from donors. J Pediatr 1980;96:679–681.

    PubMed  CAS  Google Scholar 

  40. Greer FR, Steichen JJ, Tsang RC. Calcium and phosphate supplements in breast milk related rickets. Am J Dis Child 1982;136:581–583.

    PubMed  CAS  Google Scholar 

  41. Chan GM, Mileur L, Hansen JW. Effects of increased calcium and phosphorous formulas and human milk on bone mineralization in preterm infants. J Pediatr Gastroenterol Nutr 1986;5:444–449.

    PubMed  CAS  Google Scholar 

  42. Minton SD, Steichen JJ, Tsang RC. Bone mineral content in term and preterm appropriate for gestational age infants. J Pediatr 1979;95:1037–1042.

    PubMed  CAS  Google Scholar 

  43. Steichen JJ, Gratton TL, Tsang RC. Osteopenia of prematurity: the cause and possible treatment. J Pediatr 1980;96:528–534.

    PubMed  CAS  Google Scholar 

  44. Tsang RC, Kleinman LI, Sutherland JM, et al. Hypocalcemia in infants of diabetic mothers: studies in calcium, phosphorus and magnesium metabolism and parahormone responsiveness. J Pediatr 1972;80: 384–395.

    PubMed  CAS  Google Scholar 

  45. Schedewie HK, Odell WD, Fisher DA, et al. Parathormone and perinatal calcium homeostasis. Pediatr Res 1979;13:1–6.

    PubMed  CAS  Google Scholar 

  46. Raisz LG. Physiologic-pharmacologic regulation of bone resorption. N Engl J Med 1970;282:909–916.

    PubMed  CAS  Google Scholar 

  47. Venkataraman PS, Tsang RC, Chen IW, et al. Pathogenesis of early neonatal hypocalcemia: studies of serum calcitonin, gastrin and plasma glucagon. J Pediatr 1987;110:599–603.

    PubMed  CAS  Google Scholar 

  48. Bancroft JD, Late-onset hypocalcemie tetany. Am J Dis Child 1986;140:92.

    PubMed  CAS  Google Scholar 

  49. Gidding SS, Minciotti AL, Langman CB. Unmasking of hypoparathyroidism in familial partial DiGeorge syndrome by challenging with disodium edatate. N Engl J Med 1988;319:1589–1591.

    PubMed  CAS  Google Scholar 

  50. Anast CS, David LS. Human neonatal hypercalcemia. In Holick MF, Gray TK, Anast CS, eds: Perinatal Calcium and Phosphorus Metabolism. New York: Elsevier, 1983;363–385.

    Google Scholar 

  51. Gertner JM. Phosphorus metabolism and its disorders in childhood. Pediatr Ann 1987;16:957–965.

    PubMed  CAS  Google Scholar 

  52. Wilz DR, Gray RW, Dominguez JH, et al. Plasma l,25-(OH)2-vitamin D concentrations and net intestinal calcium, phosphate, and magnesium absorption in humans. Am J Clin Nutr 1979;32:2052–2060.

    PubMed  CAS  Google Scholar 

  53. Brickman AS, Hartenbower DL, Norman AW, et al. Actions of 1α-hydroxyvitamin D3 and 1,25-dihy-droxyvitamin D3 on mineral metabolism in man. I. Effects on net absorption of phosphorus. Am J Clin Nutr 1977;30:1064–1069.

    PubMed  CAS  Google Scholar 

  54. Rasmussan H, Bordier P, Kurokawa K, et al. Hormonal control of skeletal and mineral homeostasis. Am J Med 1974;56:751–758.

    Google Scholar 

  55. Foster GV, Byfield PGH, Gundmundson TV. Calcitonin. Clin Endocrinol Metab 1972;1:93–124.

    Google Scholar 

  56. Singer FR, Melvin KEW, Mills BG. Acute effects of calcitonin on osteoclasts in man. Clin Endocrinol (Oxf) 1976;5:333s–340s.

    Google Scholar 

  57. Deluca HF. Some new concepts emanating from a study of the metabolism and function of vitamin D. Nutr Rev 1980;38:169–182.

    PubMed  CAS  Google Scholar 

  58. Garel JM, Gilbert M. Dietary calcium and phosphorus manipulations in thyroparathyroidectomized pregnant rats and fetal liver glycogen stores. Reprod Nutr Rev 1981;21:969–972.

    CAS  Google Scholar 

  59. Pitkin RM. Calcium metabolism in pregnancy and the perinatal period: a review. Am J Obstet Gynecol 1985;151:99–109.

    PubMed  CAS  Google Scholar 

  60. Ziegler EE, Biga RL, Foman SJ. Nutritional requirements of the premature infant. In Suskind RM, ed: Textbook of Pediatric Nutrition. New York: Raven Press, 1981;29–40.

    Google Scholar 

  61. David L, Anast CS. Calcium metabolism in newborn infants. J Clin Invest 1974;54:287–296.

    PubMed  CAS  Google Scholar 

  62. Parfitt AM, Kleerekoper M. Divalent ion homeostatic system physiology and metabolism of calcium, phosphorus, magnesium, and bone. In Maxel MH, Kleeman CR, eds: Clinical Disorders of Fluid and Electrolyte Metabolism. New York: McGraw-Hill, 1980;269–398.

    Google Scholar 

  63. Connelly JP, Crawford JD, Watson J. Studies of neonatal hyperphosphatemia. Pediatrics 1962;43:425–432.

    Google Scholar 

  64. Lineralli LG. Newborn urinary cAMP and developmental renal responsiveness to parathyroid hormone. Pediatrics 1972;50:14–23.

    Google Scholar 

  65. Hoehn GJ, Carey DE, Rowe JC, et al. Alternate day infusion of calcium and phosphate in very low birth weight infants: wasting of the infused mineral. J Pediatr Gastroenterol Nutr 1987;6:752–757.

    PubMed  CAS  Google Scholar 

  66. Baylink D, Wergedal S, Stauffer M. Formation, mineralization and resorption of bone in hypophosphatemic rats. J Clin Invest 1971;50:2519–2530.

    PubMed  CAS  Google Scholar 

  67. Raisz LG, Niemann I. Effect of phosphate, calcium and magnesium on bone resorption and hormonal responses in tissue culture. Endocrinology 1969;85: 446–452.

    PubMed  CAS  Google Scholar 

  68. Roberts CC, Chan GM, Folland D, et al. Adequate bone mineralization in breastfed infants. J Pediatr 1981;99:192–196.

    PubMed  CAS  Google Scholar 

  69. Senterre J, Putet G, Salle B, et al. Effects of vitamin D and phosphorus supplementation on calcium retention in preterm infants fed banked human milk. J Pediatr 1983;103:305–307.

    PubMed  CAS  Google Scholar 

  70. Schanler RJ, Garza C, Smith EO. Fortified mothers’ milk for very low birth weight infants: results of macromineral balance studies. J Pediatr 1985;107:767–774.

    PubMed  CAS  Google Scholar 

  71. Lyon AJ, Mcintosh N. Calcium and phosphorus balance in extremely low birthweight infants in the first six weeks of life. Arch Dis Child 1984;59:1145–1150.

    PubMed  CAS  Google Scholar 

  72. Schanler RJ, Abrams SA, Garza C. Bioavailability of calcium and phosphorus in human milk fortifiers and formula for very low birth weight infants. J Pediatr 1988;113:95–100.

    PubMed  CAS  Google Scholar 

  73. Carey DE, Rowe JC, Goetz CA, et al. Growth and phosphorus metabolism in premature infants fed human milk, fortified human milk, or special premature formula. Am J Dis Child 1987;141:511–515.

    PubMed  CAS  Google Scholar 

  74. Greer FR, Tsang RC. Calcium, phosphorus, magnesium and vitamin D requirements of the preterm infant. In Tsang RC, ed: Vitamin and Mineral Requirements in Preterm Infants. New York: Marcel Dekker, 1985;99–136.

    Google Scholar 

  75. Rowe JC, Goetz CA, Carey DE, et al. Achievement of in utero retention of calcium and phosphorus accompanied by high calcium excretion in very low birth weight infants fed a fortified formula. J Pediatr 1987;110:581–585.

    PubMed  CAS  Google Scholar 

  76. Anast CS, Gardner DW. Magnesium metabolism. In Bronner F, Coburn JW, eds: Disorders of Mineral Metabolism: Pathophysiology of Calcium, Phosphorus and Magnesium. Orlando: Academic Press, 1981;423–522.

    Google Scholar 

  77. Jukarainen E. Plasma magnesium levels during the first five days of life. Acta Pediatr Scand 1971;61: 5–16.

    Google Scholar 

  78. Wacker WEC, Parisi AF. Magnesium metabolism. N Engl J Med 1968;278:658–717.

    PubMed  CAS  Google Scholar 

  79. Rall TW, Sutherland EW. Formation of a cyclic adenine ribonucleotide by tissue particles. J Biol Chem 1958;232:1065–1076.

    PubMed  CAS  Google Scholar 

  80. Anast CS, Winnacker JL, Forte LR, et al. Impaired release of parathyroid hormone in magnesium deficiency. J Clin Endocrinol Metab 1976;42:707–717.

    PubMed  CAS  Google Scholar 

  81. Buckle RM, Care AD, Cooper CW. The influence of plasma magnesium concentration on parathyroid hormone secretion. J Endocrinol 1968;42:529–534.

    PubMed  CAS  Google Scholar 

  82. Choisi IN, Steinberg SF, Tropper PS, et al. The influence of hypermagnesemia on serum calcium and parathyroid hormone levels in human subjects. N Engl J Med 1984;310:1221–1225.

    Google Scholar 

  83. Suh SM, Tashjian AH Jr, Matsuo N, et al. Pathogenesis of hypocalcemia in primary hypomagnesemia: normal end-organ responsiveness to parathyroid hormone, impaired parathyroid gland function. J Clin Invest 1973;52:153–160.

    PubMed  CAS  Google Scholar 

  84. MacManus J, Heaton FW, Lucas PW. A decreased response to parathyroid hormone in magnesium deficiency. J Endocrinol 1971;49:253–258.

    PubMed  CAS  Google Scholar 

  85. Freitag JJ, Martin KJ, Conrades MB, et al. Evidence for skeletal resistance to parathyroid hormone in magnesium deficiency. J Clin Invest 1979;64:1238–1244.

    PubMed  CAS  Google Scholar 

  86. Abe M, Sherwood LM. Regulation of parathyroid hormone secretion by adenyl cyclase. Biochem Biophys Res Commun 1972;48:396–401.

    PubMed  CAS  Google Scholar 

  87. Clemens TL, Holick MF. Recent advances in the hormonal regulation of calcium and phosphorus in adult animals and humans. In Holick MF, Gray TK, Anast CS, eds: Perinatal Calcium and Phosphorus Metabolism. New York: Elsevier, 1983;1–18.

    Google Scholar 

  88. Radde IC, Parkinson DK, Koo HSW. Magnesium and calcitonin;plasma magnesium levels in anemic children and in neonates. In: Proceedings of XIII International Congress Pediatrics, Metab Vorlag der Wiener Medizinishen Akademie, Wien, Vol. VII, 1971;345.

    Google Scholar 

  89. Wilkinson R. Absorption of calcium phosphorus and magnesium. In Nordin BEC, ed: Calcium, Phosphate and Magnesium Metabolism. Edinburgh: Churchill Livingstone, 1976;36–112.

    Google Scholar 

  90. Brown IRF, Brooke OG, Haswell DJ. Vitamin D and plasma magnesium in pregnancy. Clin Chim Acta 1981;111:109–111.

    PubMed  CAS  Google Scholar 

  91. Rude RK, Adams JS, Ryzen E, et al. Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency. J Clin Endocrinol Metab 1985;61:933–940.

    PubMed  CAS  Google Scholar 

  92. Ghazarian JG, DeLuca HF. 25-Hydroxycholecalciferal-1-hydroxylase: a specific requirement for NADPH and a hemoprotein component in chick kidney mitochondria. Arch Biochem Biophys 1974;160:63–72.

    PubMed  CAS  Google Scholar 

  93. Brannan PG, Vergnc-Marini D, Pat CYC, et al. Magnesium absorption in the human small intestine. J Clin Invest 1976;57:1412–1418.

    PubMed  CAS  Google Scholar 

  94. Skyberg D, Stromme JH, Nesbakken R, et al. Neonatal hypomagnesemia with selective malabsorption of magnesium—a clinical entity. Scand J Clin Lab Invest 1968;21:355–363.

    PubMed  CAS  Google Scholar 

  95. Stromme JH, Nesbakken R, Normann T, et al. Familial hypomagnesemia. Acta Pediatr Scand 1969;58:433–444.

    CAS  Google Scholar 

  96. Levine BS, Coburn JW. Magnesium, the mimic/antagonist of calcium. N Engl J Med 1984;310:1253–1255.

    PubMed  CAS  Google Scholar 

  97. Alcock N, MacIntyre I. Interrelationship of calcium and magnesium absorption. Clin Sci 1962;22:185–193.

    PubMed  CAS  Google Scholar 

  98. Brunnette MG, Vignaoult N, Carriere S. Micropuncture study of Mg transport along the nephron in the young rat. Am J Physiol 1974;227:891–896.

    Google Scholar 

  99. Brunnette MG, Vignaoult N, Carriere S. Magnesium handling by the papilla of the young rat. Pfleugers Arch 1978;373:229–235.

    Google Scholar 

  100. Pitkin RM. Maternal-fetal calcium homeostasis. In Holick MF, Gray TK, Anast CS, eds: Perinatal Calcium and Phosphorus Metabolism. New York: Elsevier, 1983;259–275.

    Google Scholar 

  101. Aikawa JK, Bruns, PD. Placental transfer and fetal tissue uptake of Mg28 in the rabbit. Proc Soc Exp Biol Med 1960;105:95–98.

    PubMed  CAS  Google Scholar 

  102. Dancis J, Springer D, Cohlan SA. Fetal homeostasis in maternal malnutrition. II. Magnesium deprivation. Pediatr Res 1971;55:131–136.

    Google Scholar 

  103. Green KW, Key TC, Coen R, et al. The effects of maternally administered magnesium sulfate on the neonate. Am J Obstet Gynecol 1983;146:29–33.

    PubMed  CAS  Google Scholar 

  104. Anast CS. Serum magnesium levels in the newborn. Pediatrics 1964;33:969–974.

    PubMed  CAS  Google Scholar 

  105. Atkinson SA, Radde IC, Anderson GH. Macromineral balances in premature infants fed their own mothers’ milk or formula. J Pediatr 1983;102:99–106.

    PubMed  CAS  Google Scholar 

  106. Tsang RC, Light IJ, Sutherland JM, et al. Possible pathogenic factors in neonatal hypocalcemia of prematurity. J Pediatr 1973;82:423–429.

    PubMed  CAS  Google Scholar 

  107. Tsang RC, Oh W. Serum magnesium levels in low birth weight infants. Am J Dis Child 1970;120:44–48.

    PubMed  CAS  Google Scholar 

  108. Tsang RC, Chen I-W, Friedman MA, et al. Parathyroid function in infants of diabetic mothers. J Pediatr 1975;86:399–404.

    PubMed  CAS  Google Scholar 

  109. Mimouni F, Tsang RC, Hertzberg VS, et al. Polycythemia, hypomagnesemia, and hypocalcemia in infants of diabetic mothers. Am J Dis Child 1986;140:798–800.

    PubMed  CAS  Google Scholar 

  110. Noguchi A, Eren M, Tsang RC. Parathyroid hormone in hypocalcemic and normocalcemic infants of diabetic mothers. J Pediatr 1980;97:112–114.

    PubMed  CAS  Google Scholar 

  111. Donovan EF, Tsang RC, Steichen JJ, et al. Neonatal hypermagnesemia: effect on parathyroid hormone and calcium homeostasis. J Pediatr 180;96:305–310.

    Google Scholar 

  112. Habner JF, Potts JT. Relative effectiveness of magnesium and calcium on the secretion and biosynthesis of parathyroid hormone in vitro. Endocrinology 1976;98:197–202.

    Google Scholar 

  113. Rasmussen H, Feinblatt S. The relationship between the actions of vitamin D, parathyroid hormone and calcitonin. Calcif Tissue Res 1971;6:265–279.

    PubMed  CAS  Google Scholar 

  114. Kukreja SC, Hargis GK, Browser EN, et al. Role of adrenergic stimuli in parathyroid hormone secretion in man. J Clin Endocrinol Metab 1975;40:478–481.

    PubMed  CAS  Google Scholar 

  115. Care AD, Bates RF, Pickard DW, et al. The effects of vitamin D metabolites and their analogues on the secretion of parathyroid hormone. Calcif Tissue Res 1976;21:142–146.

    PubMed  Google Scholar 

  116. Dietel M, Dorn G, Montz R, et al. Influence of vitamin D3, 1,25-dihydroxy-vitamin D3 and 24,25- dihy-droxyvitamin D3 on parathyroid hormone secretion, adenosine 3’5’-monophosphate release, and ultrastructure of parathyroid glands in organ culture. Endocrinology 1979;105:237–245.

    PubMed  CAS  Google Scholar 

  117. Agus ZS, Puschett JB, Senesky D, et al. Mode of action of parathyroid hormone on cyclic adenosine 3’5’-monophosphate on renal tubular phosphate reab-sorption in the dog. J Clin Invest 1971;50:517–626.

    Google Scholar 

  118. Norden BEC, Peacock M. Role of the kidney in regulation of plasma calcium. Lance 1969;2:1280–1283.

    Google Scholar 

  119. Root AW, Harrison HE. Recent advances in calcium metabolism. II Disorders of calcium homeostasis. J Pediatr 1976;88:177–199.

    PubMed  CAS  Google Scholar 

  120. Cushard WG, Creditor MA, Canterbury, et al. Physiologic hyperparathyroidism in pregnancy. J Clin Endocrinol Metab 1976;34:767–771.

    Google Scholar 

  121. Lequin RM, Hackeng WH, Schopman W A radioimmunoassay for parathyroid hormone in man. II. Measurement of parathyroid hormone concentrations in human plasma by means of a radioimmunoassay for bovine hormone. Acta Endocrinol (Copenh) 1970;63: 655–666.

    CAS  Google Scholar 

  122. Croley TE. The intracellular localization of calcium within the mature human placenta barrier. Am J Obstet Gynecol 1973;117:926–932.

    PubMed  CAS  Google Scholar 

  123. Northrop G, Misenheimer HR, Becker FO. Failure of parathyroid hormone to cross the nonhuman primate placenta. Am J Obstet Gynecol 1977;129:449–453.

    PubMed  CAS  Google Scholar 

  124. Samaan NA, Wigoda C, Castillo SG. Human serum calcitonin and parathyroid hormone levels in the maternal, umbilical cord blood and postpartum. In: Proceedings of the Fourth International Symposium on Endocrinology. London: Heinemann, 1973;364–372.

    Google Scholar 

  125. Hillman LS, Slatopolsky E, Haddad JG. Perinatal vitamin D metabolism. IV. Maternal and cord serum 24,25-dihydroxyvitamin D concentrations. J Clin Endocrinol Metab 1978;47:1073–1077.

    PubMed  CAS  Google Scholar 

  126. Tsang RC, Chen IW, Friedman M, et al. Neonatal parathyroid function: role of gestational and postnatal age. J Pediatr 1973;83:728–738.

    PubMed  CAS  Google Scholar 

  127. Pitkin RM, Cruikshank DP, Schauberger CW, et al. Fetal calcitropic hormones and neonatal calcium homeostasis. Pediatrics 1980;66:77–82.

    PubMed  CAS  Google Scholar 

  128. Leroyer-Alizon E, David L, Anast CS, et al. Immuno-cytologic evidence for parathyroid hormone in human parathyroid glands. J Clin Endocrinol Metab 1981;52:513–516.

    PubMed  CAS  Google Scholar 

  129. Fleishman AR, Lerman S, Oakes GK, et al. Perinatal primate parathyroid hormone metabolism. Biol Neonate 1975;27:40–49.

    Google Scholar 

  130. Pitkin RM, Reynolds WA, Williams GA, et al. Maternal and fetal parathyroid hormone responsiveness in pregnant primates. J Clin Endocrinol Metab 1980;51: 1044–1047.

    PubMed  CAS  Google Scholar 

  131. Pic P, Maniey J, Jost A. Facteurs endocriniens reglant la calcemia foetale: indications sur le role des parathyroides. CR Soc Biol 1965;159:1274–1277.

    CAS  Google Scholar 

  132. Garel JM. Effet de l’injection d’un serum “anti-parathormone” chez le foetus de rat. CR Acad Sci 1970;271:349–350.

    Google Scholar 

  133. Hillman LS, Rojanasathit S, Slatopolsky E, et al. Serial measurements of serum calcium, magnesium, parathyroid hormone, calcitonin, and 25-hydroxy-vitamin D in premature and term infants during the first week of life. Pediatr Res 1977;11:739–744.

    PubMed  CAS  Google Scholar 

  134. Delvin EE, Glorieux FH, Salle BL, et al. Control of vitamin D metabolism in preterm infants: feto-maternal relationships. Arch Dis Child 1982;57:754–757.

    PubMed  CAS  Google Scholar 

  135. Dincsoy MY, Tsang RC, Laskarzewski P, et al. The role of postnatal age and magnesium on parathyroid hormone responses during “exchange” blood transfusion in the newborn period. J Pediatr 1982;100:277–283.

    PubMed  CAS  Google Scholar 

  136. Linerelli LG, Bobik C, Bobik J. Urinary cAMP and renal responsiveness to parathyroid hormone in premature hypocalcemic infants. Pediatr Res 1973;7:329A.

    Google Scholar 

  137. Hillman DA, Scriver CR, Pedvis S, et al. Neonatal familial primary hyperparathyroidism. N Engl J Med 1964;280:483–490.

    Google Scholar 

  138. Loughead JL, Mughal Z, Mimouni F, et al. The spectrum and natural history of congenital hyperparathyroidism secondary to maternal hypocalcemia. Am J Perinatol 1990;7:350–355.

    PubMed  CAS  Google Scholar 

  139. Winter WE, Silverstein JH, Barrett DS, et al. Familial DiGeorge syndrome with tetralogy of Fallot and prolonged survival. Eur J Pediatr 1984;141:171–172.

    PubMed  CAS  Google Scholar 

  140. Raatikka M, Rapola J, Tuuteri L, et al. Familial third and fourth pharyngeal pouch syndromes with truncus arteriosus: DiGeorge syndrome. Pediatrics 1981;67: 173–175.

    PubMed  CAS  Google Scholar 

  141. Bainbridge R, Mughal Z, Mimouni F, et al. Transient congenital hypoparathyroidism: how transient is it? J Pediatr 1987;111:866–868.

    PubMed  CAS  Google Scholar 

  142. Bayard J, Bec P, Louvet D, et al. 25-Hydroxychole-calciferol dynamics in human plasma. In: IV International Congress of Endocrinology. Amsterdam: Excerpta Medica, 1972 597A.

    Google Scholar 

  143. Bronner F, Pansu D, Stein WD. An analysis of intestinal calcium transport across the rat intestine. Am J Physiol 1986;250:6561–6569.

    Google Scholar 

  144. Bordier P, Rasmussen H, Marie P, et al. Vitamin D metabolites and bone mineralization in man. J Clin Endocrinol Metab 1978;46:284–294.

    PubMed  CAS  Google Scholar 

  145. Kanis JA, Cundy T, Bartlett M, et al. Is 24,25-dihy-droxy cholecalceferol a calcium-regulating hormone in man? Br Med J 1978;1:1382–1386.

    PubMed  CAS  Google Scholar 

  146. Henry HL, Norman AW. Vitamin D: two dihydroxyl-ated metabolites are required for normal chicken egg hatchability. Science 1978;201:835–837.

    PubMed  CAS  Google Scholar 

  147. Bouillon R, Van Baelen H, DeMoor P. 25-Hydroxy-vitamin D and its binding protein in maternal and cord blood serum. J Clin Endocrinol Metab 1977;45:679–684.

    PubMed  CAS  Google Scholar 

  148. Haddad JG, Welgate J. Radioimmunoassay of the binding protein for vitamin D and its metabolites in human serum: concentrations in normal subjects and patients with disorders of mineral homeostasis. J Clin Invest 1976;58:1217–1222.

    PubMed  CAS  Google Scholar 

  149. Hollis BW, Pittard WB. Relative concentrations of 25-hydroxyvitamin D2/D3 and 1,25-dihydroxyvitamin D2/D3 in maternal plasma at delivery. Nutr Res 1984;4:27–32.

    CAS  Google Scholar 

  150. Reiter EO, Braunstein GD, Vargas A, et al. Changes in 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D during pregnancy. Am J Obstet Gynecol 1979;135: 227–229.

    PubMed  CAS  Google Scholar 

  151. Delvin EE, Salle BL, Glorieux FH, et al. Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr 1986;109:328–334.

    PubMed  CAS  Google Scholar 

  152. Hillman LS, Haddad GJ. Perinatal vitamin D metabolism. III. Factors influencing late gestational human serum 25-hydroxyvitamin D. Am J Obstet Gynecol 1976;125:196–200.

    PubMed  CAS  Google Scholar 

  153. Whitehead M, Lane G, Young O, et al. Interrelations of calcium-regulating hormones during normal pregnancy. Br Med J 1981;283:10–31.

    CAS  Google Scholar 

  154. Mallet E, Gugi B, Brunelle P, et al. Vitamin D supplementation in pregnancy: a controlled trial of two methods. Obstet Gynecol 1986;68:300–304.

    PubMed  CAS  Google Scholar 

  155. Hillman LS, Haddad JG. Human perinatal vitamin D metabolism. I. 25-Hydroxyvitamin D in maternal and cord blood. J Pediatr 1974;84:742–749.

    PubMed  CAS  Google Scholar 

  156. Nehama H, Weintroub S, Eisenberg Z, et al. Seasonal variations in paired maternal-newborn serum 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D concentrations in Israel. J Med Sci 1987;23:274–277.

    CAS  Google Scholar 

  157. Bruns ME, Bruns DE. Vitamin D metabolism and function during pregnancy and the neonatal period. Anim Clin Lab Sci 1983;13:521–530.

    CAS  Google Scholar 

  158. Haddad JG, Boisseau V, Avioli LV Placental transfer of vitamin D3 and 25-hydroxycholecalciferol in the rat. J Lab Clin Med 1971;77:908–915.

    PubMed  CAS  Google Scholar 

  159. Devaskar UP, Ho M, Devaskar S, et al. 25-Hydroxy-and 1,25-dihydroxyvitamin D;maternal-fetal relationship and the transfer of 1,25-dihydroxyvitamin D3 across the placenta in an ovine model. Dev Pharmacol Ther 1984;7:213–220.

    PubMed  CAS  Google Scholar 

  160. Hillman LS, Haddad JG. Perinatal vitamin D metabolism. II. Serial 25-hydroxyvitamin D concentrations in sera of term and premature infants. J Pediatr 1975;86:928–935.

    PubMed  CAS  Google Scholar 

  161. Axelson M, Christensen NJ. Vitamin D metabolism in human pregnancy: concentrations of free and sulphated 25-hydroxyvitamin D3 in maternal and fetal plasma at term. J Steroid Biochem 1988;31:35–39.

    PubMed  CAS  Google Scholar 

  162. Epstein EH, Han A, Shackleton CH. Failure of steroid sulfatase to desulfate vitamin D3 sulfate. J Invest Dermatol 1983;80:514–516.

    PubMed  Google Scholar 

  163. Glorieux FH, Salle B, Delvin EE, et al. Vitamin D metabolism in premature infants: serum calcitriol values during the first five days of life. J Pediatr 1981;99:640–643.

    PubMed  CAS  Google Scholar 

  164. Robinson M, Merrett A, Teflow V, et al. Plasma 25-hydroxyvitamin D concentrations in preterm infants receiving oral vitamin D supplements. Arch Dis Child 1981;56:144–145.

    PubMed  CAS  Google Scholar 

  165. Salle B, Glorieux F, Delvin E, et al. Vitamin D metabolism in preterm infants. Acta Pediatr Scand 1983;72:203–206.

    CAS  Google Scholar 

  166. Markestad T, Asknes L, Finne P, et al. Plasma concentrations of vitamin D metabolites in premature infants. Pediatr Res 1984;18:269–272.

    PubMed  CAS  Google Scholar 

  167. Kumar R, Colon WR, Silva P, et al. Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J Clin Invest 1979;63:342–344.

    PubMed  CAS  Google Scholar 

  168. Reddy GS, Norman AW, Willis DM, et al. Regulation of vitamin D metabolism in normal human pregnancy. J Clin Endocrinol Metab 1983;56:363–370.

    PubMed  CAS  Google Scholar 

  169. Steichen JJ, Tsang RC, Gratton TL, et al. Vitamin D homeostasis in the perinatal period: 1,25-dihydroxy-vitamin D in maternal, cord and neonatal blood. N Engl J Med 1980;302:315–319.

    PubMed  CAS  Google Scholar 

  170. Nguyen TM, Halhale A, Guillozo H, et al. Thyroid and parathyroid-independent increase in plasma 1,25-dihydroxyvitamin D during late pregnancy in the rat. J Endocrinol 1988;116:381–385.

    PubMed  CAS  Google Scholar 

  171. Spanos E, Brown DJ, Stevenson JC, et al. Stimulation of 1,25-dihydroxycholecalciferal production by prolactin and related peptides in intact renal cell preparations in vitro. Biochim Biophys Acta 1981;672:7–15.

    PubMed  CAS  Google Scholar 

  172. Pahuja DW, DeLuca HE Stimulation of intestinal calcium transport and bone calcium mobilization by prolactin in vitamin D deficient rats. Science 1981;214:1038–1039.

    PubMed  CAS  Google Scholar 

  173. Fleischman AR, Rosen JF, Cole J, et al. Maternal and fetal serum 1,25-dihydroxyvitamin D levels at term. J Pediatr 1980;97:640–642.

    PubMed  CAS  Google Scholar 

  174. Hollis BW, Pittard WB. Evaluation of the total fetomaternal vitamin D relationship at term: evidence for racial differences. J Clin Endocrinol Metab 1984;59:652–657.

    PubMed  CAS  Google Scholar 

  175. Weiland T, Fischer JA, Trechsel U, et al. Perinatal parathyroid, vitamin D metabolites, and calcitonin in man. Am J Physiol 1980;239:E385–E390.

    Google Scholar 

  176. Ross R, Care AD, Taylor CM, et al. The transplacental movement of metabolites of vitamin D in the sheep. In Norman AW, Schaefer K, Coburn JW, et al, eds: Vitamin D Basic Research in its Clinical Application. Berlin: de Gruyter, 1979;341–344.

    Google Scholar 

  177. Somjen D, Binderman I, Weisman Y. The effects of 24R,25-dihydroxycholecalciferol and of 1α,25-dihy-droxycholecalciferol on ornithine decarboxylase activity and on DNA synthesis in the epiphysis and diaphysis of rat bone and in the duodenum. Biochem J 1983;214:293–298.

    PubMed  CAS  Google Scholar 

  178. Paunier L, LaCourt G, Pilloud P, et al. 25-Hydroxy-vitamin D and calcium levels in maternal, cord and infant serum in relation to maternal vitamin D intake. Helv Pediatr Acta 1978;33:95–103.

    CAS  Google Scholar 

  179. Heckmatt JZ, Peacock M, Davies AE, et al. Plasma 25-hydroxyvitamin D in pregnant Asian women and their babies. Lancet 1979;2:546–548.

    PubMed  CAS  Google Scholar 

  180. Clements MR, Frasier DR. Vitamin D supply to the rat fetus and neonate. J Clin Invest 1988;81:1768–1773.

    PubMed  CAS  Google Scholar 

  181. Specker BL, Tsang RC, Hollis BW Effect of race and diet on human-milk vitamin D and 25-hydroxyvitamin D. Am J Dis Child 1985;139:1134–1137.

    PubMed  CAS  Google Scholar 

  182. Greer FR, Ho M, Dodson D, et al. Lack of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in human milk. J Pediatr 1981;99:233–235.

    PubMed  CAS  Google Scholar 

  183. Parthemore JG, Deftos LJ. Calcitonin secretion in normal human subjects. J Clin Endocrinol 1978;47: 184–188.

    CAS  Google Scholar 

  184. Hillyard CJ, Cooke TJC, Coombes RC, et al. Normal plasma calcitonin: circadian variation and response to stimuli. Clin Endocrinol (Oxf) 1977;6: 291–298.

    CAS  Google Scholar 

  185. Care AD, Bell NH, Bates RFL. The effect of hypermagnesemia on calcitonin secretion in vivo. J Endocrinol 1971;51:381–386.

    PubMed  CAS  Google Scholar 

  186. Anast C, David L, Winnacker J, et al. Serum calcitonin-lowering effect of magnesium in patients with medullary carcinoma of the thyroid. J Clin Invest 1975;56:1615–1621.

    PubMed  CAS  Google Scholar 

  187. Roos BA, Deftos LJ. Calcitonin secretion in vitro. II. Regulating effects of enteric mammalian polypeptide hormones on tract C-cell cultures. Endocrinology 1976;98:1284–1288.

    PubMed  CAS  Google Scholar 

  188. Care AD. Effect of pancreozymin and secretion on calcitonin release. Fed Proc 1970;29:53A.

    Google Scholar 

  189. Cooper CW, Mahgoub AH. Stimulation of secretion of pig thyrocalcitonin by pentogastrin. Fed Proc 1971;30:417A.

    Google Scholar 

  190. Garel JM, Barlet JP, Kervran A. Metabolic effects of calcitonin in the newborn. Am J Physiol 1975;229: 669–675.

    PubMed  CAS  Google Scholar 

  191. Reynolds JJ. Inhibition by calcitonin of bone resorption induced in vitro by vitamin A. Proc R Soc [B] 1968;170:61–69.

    CAS  Google Scholar 

  192. Krane SM, Harris ED Jr, Singer FR, et al. Acute effects of calcitonin on bone formation in man. Metabolism 1973;22:51–58.

    PubMed  CAS  Google Scholar 

  193. Chambers TJ, McSheehy PMS, Thomson BM, et al. The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts dis-saggregated from neonatal rabbit bones. Endocrinology 1985;60:234–239.

    Google Scholar 

  194. Marcus R, Heershe JNM, Aurbach GD. Effects of calcitonin on formation of 3′5′cyclic AMP in bone and kidney. In: Program of the Fifty-Third Annual Meeting US Endocrine Society 1971, 57A.

    Google Scholar 

  195. Potts JT Jr, Murray TM, Peacock M, et al. Parathyroid hormone: sequence synthesis, immunoassay studies. Am J Med 1971;50:639–649.

    PubMed  CAS  Google Scholar 

  196. Cramer CF, Parkes CO, Copp D. The effect of chicken and hog calcitonin as some parameters of Ca, P and Mg metabolism in dogs. Can J Physiol Pharmacol 1969;47:181–184.

    PubMed  CAS  Google Scholar 

  197. Robinson CJ, Matthews EW, MacIntyre I. The effect of parathyroid hormone and thyrocalcitonin on intestinal absorption of calcium and magnesium. In Milhaud G, Owen M, Blackwood D, eds: Les Tissues Calcifics: Ve Symposium European. Paris: Societe d’Editron d’Enseignement Superieur, 1968;279–282.

    Google Scholar 

  198. Garel JM, Milhaud G, Sizonenko PC. Inactivation de la calcitonine porcine par differents organes, foetaux et maternais du rat. CR Acad Sci 1970;270:2469–2471.

    CAS  Google Scholar 

  199. Ardaillou R, Sizonenko P, Meyrier A, et al. Metabolic clearance rate of radioiodinated human calcitonin in man. J Clin Invest 1970;49:2345–2352.

    PubMed  CAS  Google Scholar 

  200. Drake TS, Kaplan RA, Lewis TA. The physiologic hyperparathyroidism of pregnancy: is it primary or secondary? Obstet Gynecol 1979;53:746–749.

    PubMed  CAS  Google Scholar 

  201. Stevenson JC, Hillyard CS, MacIntyre I, et al. The physiological role for calcitonin: protection of the maternal skeleton. Lancet 1979;2:769–770.

    PubMed  CAS  Google Scholar 

  202. Reynolds WA, Williams GA, Pitkin RM. Calcitropic hormone responsiveness during pregnancy. Am J Obstet Gynecol 1981;139:855–862.

    PubMed  CAS  Google Scholar 

  203. Taylor TG, Lewis PE, Balderstone O. Role of calcitonin in protecting the skeleton during pregnancy and lactation. J Endocrinol 1975;66:297–308.

    PubMed  CAS  Google Scholar 

  204. Milhaud G, Maukhtar MS, Perault-Straub AM, et al. Calcitonin. In Taylor S, Foster GV, eds: Calcitonin, Proceedings Second International Symposium. London: Heinemann, 1969;182–193.

    Google Scholar 

  205. Leroyer-Alizon E, David L, Dubois PM. Evidence for calcitonin in the thyroid gland of normal and anencephalic human fetuses: immunocytological localization, radioimmunoassay and gel filtration of thyroid extracts. J Clin Endocrinol 1980;50:316–321.

    CAS  Google Scholar 

  206. Pearse AGE. Calcitonin. In Taylor S, Foster GV, eds: Calcitonin, Proceedings Second International Symposium. London: Heinemann, 1969;125–140.

    Google Scholar 

  207. Samaan NA, Anderson GD, Adam-Mayne ME. Immunoreactive calcitonin in the mother, neonate, child, and adult. Am J Obstet Gynecol 1975;121:622–625.

    PubMed  CAS  Google Scholar 

  208. David L, Salle BL, Putet G, et al. Serum immunoreactive calcitonin in low birth weight infants. Pediatr Res 1981;15:803–808.

    PubMed  CAS  Google Scholar 

  209. Littledike ET, Arnaud CD, Whipp SC. Calcitonin secretion in ovine, porcine and bovine fetuses. Proc Soc Exp Biol Med 1972;139:428–433.

    PubMed  CAS  Google Scholar 

  210. Garel JM, Sajarol H, Barlet JP, et al. Dosage radioim-munologique de la calcitone, chez le foetus de montaun. CR Acad Sci 1973;277:217–220.

    CAS  Google Scholar 

  211. Cruikshank DR, Pitkin RM, Reynolds WA, et al. Calcium regulating hormones and ions in amniotic fluid. Am J Obstet Gynecol 1980;136:621–625.

    PubMed  CAS  Google Scholar 

  212. Weiss RE, Singer FR, Gorn AH, et al. Calcitonin stimulates bone formation when administered prior to initiation of osteogenesis. J Clin Invest 1981;68:815–818.

    PubMed  CAS  Google Scholar 

  213. Bergman L, Kjellmer I, Selstam U. Calcitonin and parathyroid hormone: relation to early neonatal hypocalcemia in infants of diabetic mothers. Biol Neonate 1974;24:151–160.

    PubMed  CAS  Google Scholar 

  214. Birge SJ, Avioli LV. Glucagon-induced hypocalcemia in man. J Clin Endocrinol 1969;29:213–218.

    CAS  Google Scholar 

  215. Mimouni F, Loughead JL, Tsang RC, et al. The role of calcitonin (CT) in neonatal hypocalcemia (NHC) in infants of diabetic mothers (IDM’s). Pediatr Res 1989;25:89A.

    Google Scholar 

  216. Johnston DI, Bloom SR. Plasma glucagon levels in the term human infant and the effect of hypoxia. Arch Dis Child 1973;48:451–454.

    PubMed  CAS  Google Scholar 

  217. David L, Salle B, Chopard P, et al. Studies on circulating immunoreactive calcitonin in low birth weight infants during the first 48 hours of life. Helv Pediatr Acta 1977;32:39–44.

    CAS  Google Scholar 

  218. Garel JM, Besnard P. Milk factors controlling the plasma calcitonin level in the newborn rat. Endocrinology 1979;104:1617–1623.

    PubMed  CAS  Google Scholar 

  219. Garel JM, Jullienne S. Plasma calcitonin levels in pregnant and newborn rats. J Endocrinol 1977;75:373–376.

    CAS  Google Scholar 

  220. Arver S, Bucht E, Sjoberg HE. Calcitonin-like immunoreactivity in human milk, longitudinal alterations and divalent cations. Acta Physiol Scand 1984;122: 461–464.

    PubMed  CAS  Google Scholar 

  221. Bucht E, Telenius-Berg M, Lundell G, et al. Immunoextracted calcitonin in milk and plasma from totally thyroidectomized women: evidence of monomeric calcitonin in plasma during pregnancy and lactation. Acta Endocrinol (Copenh) 1986;113:529–535.

    CAS  Google Scholar 

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Loughead, J.L., Tsang, R.C. (1991). Neonatal Mineral Metabolism. In: Cowett, R.M. (eds) Principles of Perinatal-Neonatal Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-0400-5_26

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